2023
DOI: 10.1021/acs.jmedchem.3c01277
|View full text |Cite
|
Sign up to set email alerts
|

Fused Tetrahydroquinolines Are Interfering with Your Assay

Frances M. Bashore,
Joel Annor-Gyamfi,
Yuhong Du
et al.

Abstract: Tricyclic tetrahydroquinolines (THQs) have been repeatedly reported as hits across a diverse range of high-throughput screening (HTS) campaigns. The activities of these compounds, however, are likely due to reactive byproducts that interfere with the assay. As a lesser studied class of pan-assay interference compounds, the mechanism by which fused THQs react with protein targets remains largely unknown. During HTS follow-up, we characterized the behavior and stability of several fused tricyclic THQs. We synthe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
references
References 39 publications
(177 reference statements)
0
0
0
Order By: Relevance