2018
DOI: 10.1002/cncr.31553
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Fusion status in patients with lymph node‐positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Abstract: Fusion status and tumor invasiveness appear to have a strong impact on prognosis in patients with aRMS/N1. Fusion status will be used to stratify these patients in the next EpSSG RMS study, and treatment will be intensified in patients with fusion-positive tumors. Cancer 2018. © 2018 American Cancer Society.

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Cited by 58 publications
(54 citation statements)
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“…1,3,5,17,18 The local therapy approach differed per protocol. Treatment generally consisted of a combination of chemotherapy with surgery and/or radiotherapy, as described previously.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…1,3,5,17,18 The local therapy approach differed per protocol. Treatment generally consisted of a combination of chemotherapy with surgery and/or radiotherapy, as described previously.…”
Section: Methodsmentioning
confidence: 99%
“…Treatment generally consisted of a combination of chemotherapy with surgery and/or radiotherapy, as described previously. 1,3,5,17,18 The local therapy approach differed per protocol. If possible, delayed surgery was performed in case of residual tumor.…”
Section: Methodsmentioning
confidence: 99%
“…Histologic diagnosis of alveolar RMS (RMA) or metastatic tumors is a known poor prognostic factor in infants . Fusion status or mutations as MYOD1 in patients with RMS are recently reported as powerful predictors of prognosis . In contrast, spindle‐cell RMS in infancy with NCOA2 gene rearrangements is reported to be associated with an excellent prognosis…”
Section: Introductionmentioning
confidence: 99%
“…4 Fusion status or mutations as MYOD1 in patients with RMS are recently reported as powerful predictors of prognosis. 11,12 In contrast, spindle-cell RMS in infancy with NCOA2 gene rearrangements is reported to be associated with an excellent prognosis. 13 In this report, we describe the characteristics, outcome, prognostic factors, pattern of relapse, long-term sequelae, and second malignancies for infants with localized and metastatic RMS treated within five trials and one registry of the Cooperative Weichteilsarkom Studiengruppe (CWS).…”
Section: Introductionmentioning
confidence: 99%
“…a sonda mais frequentemente utilizada é a FOXO1 gene dual color break-apart que pode detectar ambas as translocações envolvendo o gene FOXO1 6,13 . atualmente, existe a proposta para a inclusão dessa alteração molecular como um dos fatores de prognóstico da doença 14 .…”
Section: Discussionunclassified