Fusobacterial liver abscess: a case report and review of the literature

Jayasimhan, Dilip; Wu, Linus; Huggan, Paul

doi:10.1186/s12879-017-2548-9

Cited by 52 publications

(43 citation statements)

References 68 publications

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“…We used the search terms, ‘ Fusobacterium nucleatum ’ and ‘“pyogenic liver abscess’ ( table 2 ). 2–4 7 9–24 There were 20 cases of PLA where F. nucleatum was implicated as the causative pathogen in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatumcausing a pyogenic liver abscess: a rare complication of periodontal disease that occurred during the COVID-19 pandemic

Collins¹,

Diamond

2021

BMJ Case Rep

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Fusobacterium nucleatum is a periodontal commensal and pathogen. In rare cases, these anaerobic gram-negative bacilli have been reported to cause pyogenic liver abscesses (PLAs). We describe a patient who developed a periodontal abscess during the COVID-19 pandemic and was unable to access the restricted General Dental Services at this time. She subsequently developed a F. nucleatum bacteraemia and liver abscess. The non-specific signs and symptoms experienced meant the patient self-isolated due to suspected COVID-19 infection and presentation to hospital was delayed. We also include the results of a literature search of other cases of PLAs attributed to F. nucleatum. PLAs often develop insidiously. They require percutaneous drainage and prolonged antimicrobial therapy. Clinicians should be aware of this rare complication of a dentoalveolar infection in a patient who is systemically unwell.

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Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatumcausing a pyogenic liver abscess: a rare complication of periodontal disease that occurred during the COVID-19 pandemic

Collins¹,

Diamond

2021

BMJ Case Rep

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“…Most of these cases occur in young or middle-aged individuals who are immunocompetent. They have no risk factors for liver disease including malignancy, end-stage renal disease or old age [4].…”

Section: Discussionmentioning

confidence: 99%

Multiloculated Liver Abscess Caused by Fusobacterium: Role of Karius Testing in Diagnosis

Zafar¹,

Rashid²,

Mandzhieva³

et al. 2020

Cureus

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Pyogenic liver abscess can be a major diagnostic and therapeutic challenge despite advances in cutting edge technologies. A patient presented with fever, right upper quadrant pain and diarrhea. CT revealed multiple hypodensities in both lobes of liver. The largest lesion was in the left lobe of liver and was multiloculated with thick septations. The causative organism was identified to be Fusobacterium nucleatum by Karius testing. The patient was discharged on six weeks of ertapenem therapy, which resulted in complete resolution. This is the first case of liver abscess where Karius testing was used to identify microorganism. It also highlights that multiloculated and difficult to drain liver abscesses caused by highly sensitive organisms can potentially be treated by intravenous antibiotics alone in immunocompetent patients.

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“…The association between Fusobacterium nucleatum and chorioamnionitis with preterm labor was found [18]. Even though, the incidence of Fusobacterium bacteremia is low (0.55 per 100.000 population per annum) [19], mortality remains significant in developing countries: 47.4 % in Taiwan [20], 4% in Finland [21][22][23][24][25][26] and 1% in New Zealand [17].…”

Section: Microbiologymentioning

confidence: 99%

Liver Abscess Secondary to Fusobacterium nucleatum Infection in 15-year-old Male

Hovsepyan¹,

Mukundan²,

Kaul³

2018

J Infect Dis Preve Med

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Pyogenic liver abscess (PLA) is an uncommon condition, which requires early diagnosis and treatment, due to high mortality, morbidity if left untreated. The incidence rate 3.6 per 100.000 populations with overall mortality 0.2 per 100.000 populations in the United States. Predisposing factors for PLA development were immune deficiency, parasitic invasion, genetic disorders (Papillon-Leferve syndrome, Chronic Granulomatous Disease), abdominal infection [4] and abdominal trauma. The most common cultured bacteria in the last population group were Streptococcus species 29.5%, E.coli 18.1% and 16.3% polymicrobial. Here we report a case of PLA secondary due to Fusobacterium nucleatum in an otherwise healthy adolescent male with no definitive source of infection (cryptogenic). PLA is very rare and to date there is no case reports published with Fusobacterium nucleatum being the causative pathogen in pediatrics (only 13 adult cases have been reported).

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Fusobacterial liver abscess: a case report and review of the literature

Cited by 52 publications

References 68 publications

Fusobacterium nucleatumcausing a pyogenic liver abscess: a rare complication of periodontal disease that occurred during the COVID-19 pandemic

Fusobacterium nucleatumcausing a pyogenic liver abscess: a rare complication of periodontal disease that occurred during the COVID-19 pandemic

Multiloculated Liver Abscess Caused by Fusobacterium: Role of Karius Testing in Diagnosis

Liver Abscess Secondary to Fusobacterium nucleatum Infection in 15-year-old Male

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