Fusobacterium nucleatum-caused brain abscess – Case report

Chen, Kuan-Pin; Lee, Yi-Pang; Hwang, Ming-Jay; Chiang, Chun‐Pin

doi:10.1016/j.jds.2021.01.007

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…In the context of the case presented here, the identified pathogens— F. nucleatum , P. gingivalis and P. micra —are anaerobic bacteria, often linked with periodontal diseases, and have been implicated in distant site infections, including brain abscesses [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Yet their direct association with ischemic stroke remains rare and underreported.…”

Section: Discussionmentioning

confidence: 99%

Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction

Kiramira,

Uphaus,

Othman

et al. 2024

Brain Sciences

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Invasive dental procedures, such as wisdom teeth removal, have been identified as potential triggers for vascular events due to the entry of oral bacteria into the bloodstream, leading to acute vascular inflammation and endothelial dysfunction. This study presents the case of a 27-year-old healthy male who developed ischemic stroke resulting from bacteremia after undergoing wisdom teeth extraction. Initially, the patient experienced fever and malaise, which were followed by right-sided hemiplegia. Diagnostic imaging, including a CT scan, identified a subacute infarction in the posterior crus of the left internal capsule, and MRI findings indicated inflammatory changes in the masticatory muscles. Further investigations involving biopsies of the masticatory muscles, along with blood and cerebrospinal fluid samples, confirmed bacterial meningitis with associated vasculitis. Notably, oral bacteria linked to periodontitis, including Porphyromonas gingivalis, Fusobacterium nucleatum, Tannerella forsythia, and Parvimonas micra, were found in the biopsies and microbiological analyses. To the best of our knowledge, this is the first reported case showing that bacteremia following dental procedures can lead to such severe neurological outcomes. This case underscores the importance of recognizing bacteremia-induced vasculitis in patients presenting with neurological symptoms post-dental procedures, emphasizing the broader implications of oral infections in such pathologies.

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Section: Discussionmentioning

confidence: 99%

Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction

Kiramira,

Uphaus,

Othman

et al. 2024

Brain Sciences

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“…Several studies have demonstrated the involvement of bacteria of the oropharyngeal flora in the pathophysiology of many systemic, cardiovascular and cerebral diseases [3, 8]. Dental infection, and particularly periodontitis and dental caries are a rare but possible starting point for brain abscesses through haematogenous spread [1–6, 8, 11–14].…”

Section: Discussionmentioning

confidence: 99%

Actinomyces israelii and Fusobacterium nucleatum brain abscess in an immunocompetent patient: case report

LAARIF

Schils

Lifrange

et al. 2023

Access Microbiology

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Introduction. Brain abscess is the most common focal infectious neurological injury. Until the nineteenth century this condition was fatal, however the development of neuroimaging for early diagnosis, neurosurgery and antibiotic therapy in the twentieth century has led to new therapeutic strategies decreasing mortality from 50 % in the 1970s to less than 10 % nowadays. In this context we report a case of brain abscess with a dental origin. Case report. A immunocompetent man without any addiction presented to the emergency department with dysarthria and frontal headache at home. The clinical examination was normal. Further investigations revealed a polymicrobial brain abscess as a consequence of an ear, nose or throat (ENT) infection with locoregional extension with a dental starting point involving Actinomyces israelii and Fusobacterium nucleatum . In spite of a rapid diagnosis and a neurosurgical management associated with an optimal treatment by a dual therapy made of ceftriaxone and metronidazole the patient unfortunately died. Conclusion. This case report shows that despite a low incidence and a good prognosis following the diagnosis, brain abscesses can lead to patient’s death. Thereby, when the patient’s condition and urgency allow, a thorough dental examination of patients with neurological signs following the recommendations would improve the diagnosis made by the clinician. The use of microbiological documentation, the respect of pre-analytical conditions, the interaction between the laboratory and the clinicians are indispensable for an optimal management of these pathologies.

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“…Alloprevotella, an oral microbiota member, has recently been linked with opportunistic infection 40 . There is numerous literature on pathogenic effects on the heart, brain and liver [41][42][43] and cancer-promoting effects of Fusobacterium 44 and its role in colitis 45 , gut pathogenesis and abundance of virulence factors 46 . Erysipelatoclostridium has one species known as highly pathogenic with a range of clinical situations, including bacteraemia, septicaemia, brain and lung abscess and other infections spanning across the host organs and tissues.…”

Section: Discussionmentioning

confidence: 99%

Phytogenic supplement containing menthol, carvacrol and carvone ameliorates gut microbiota and production performance of commercial layers

Bajagai

Petranyi

et al. 2022

Sci Rep

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Consumer push towards open and free-range production systems makes biosecurity on farms challenging, leading to increased disease and animal welfare issues. Phytogenic products are increasingly becoming a viable alternative for the use of antibiotics in livestock production. Here we present a study of the effects of commercial phytogenic supplement containing menthol, carvacrol and carvone on intestinal microbiota of layer hens, microbial functional capacity, and intestinal morphology. A total of 40,000 pullets were randomly assigned to two sides of the experimental shed. Growth performance, mortality, egg production and egg quality parameters were recorded throughout the trial period (18–30 weeks of age). Microbial community was investigated using 16S amplicon sequencing and functional difference using metagenomic sequencing. Phytogen supplemented birds had lower mortality and number of dirty eggs, and their microbial communities showed reduced richness. Although phytogen showed the ability to control the range of poultry pathogens, its action was not restricted to pathogenic taxa, and it involved functional remodelling the intestinal community towards increased cofactor production, heterolactic fermentation and salvage and recycling of metabolites. The phytogen did not alter the antimicrobial resistance profile or the number of antibiotic resistance genes. The study indicates that phytogenic supplementation can mimic the action of antibiotics in altering the gut microbiota and be used as their alternative in industry-scale layer production.

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Fusobacterium nucleatum-caused brain abscess – Case report

Cited by 5 publications

References 4 publications

Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction

Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction

Actinomyces israelii and Fusobacterium nucleatum brain abscess in an immunocompetent patient: case report

Phytogenic supplement containing menthol, carvacrol and carvone ameliorates gut microbiota and production performance of commercial layers

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