Future Challenges in Research in Children with Neurodevelopmental Disorders

Ayuso, Dulce María Romero

doi:10.3390/children8050328

Cited by 4 publications

(1 citation statement)

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“…Neurodevelopmental disorders (NDD) are a broad spectrum of early onset syndromes affecting the development of the central nervous system (CNS) with a prevalence in children that exceeds 15% worldwide ( Romero-Ayuso, 2021 ). Formerly referred to as “mental retardation” NDD are typically characterized by deficits in cognitive function and adaptive behavior ( Micai et al, 2020 ; Hanly et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis

Ebstein

Küry

Papendorf

et al. 2021

Front. Mol. Neurosci.

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Over thirty years have passed since the first description of ubiquitin-positive structures in the brain of patients suffering from Alzheimer’s disease. Meanwhile, the intracellular accumulation of ubiquitin-modified insoluble protein aggregates has become an indisputable hallmark of neurodegeneration. However, the role of ubiquitin and a fortiori the ubiquitin-proteasome system (UPS) in the pathogenesis of neurodevelopmental disorders (NDD) is much less described. In this article, we review all reported monogenic forms of NDD caused by lesions in genes coding for any component of the UPS including ubiquitin-activating (E1), -conjugating (E2) enzymes, ubiquitin ligases (E3), ubiquitin hydrolases, and ubiquitin-like modifiers as well as proteasome subunits. Strikingly, our analysis revealed that a vast majority of these proteins have a described function in the negative regulation of the innate immune response. In this work, we hypothesize a possible involvement of autoinflammation in NDD pathogenesis. Herein, we discuss the parallels between immune dysregulation and neurodevelopment with the aim at improving our understanding the biology of NDD and providing knowledge required for the design of novel therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%