Future outlook for drug eluting stents

Vedantham, Kumar; Chaterji, Somali; Kitsongsermthon, Jutarat; Park, K.; Garner, John

doi:10.1533/9781845697488.2.118

Cited by 7 publications

(4 citation statements)

References 156 publications

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“…PTX has been approved by the US FDA for the treatment of breast, ovarian, and non-small-cell lung cancer [ 1 , 77 ]. In this work, the cytotoxicity of PTX in comparison with PTX-loaded DC-WCS-PG NPs against CRL 2522 fibroblasts and MCF-7 breast cancer cells was examined using the MTT assay.…”

Section: Resultsmentioning

confidence: 99%

“…This issue seriously limits further clinical use of the drugs to achieve high treatment efficiency. Enhancing the solubility of water-insoluble drugs, such as paclitaxel (PTX) and berberine (BBR), has received significant attention [ 1 , 2 ]. Efforts have been made towards the design of sophisticated drug structures and formulations using various nanomaterials, such as liposome and lipid micelles [ 3 ], nanoparticles (NPs), nanocapsules [ 4 ], and amphiphilic core–shell nanoparticles [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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pH-Responsive Water-Soluble Chitosan Amphiphilic Core–Shell Nanoparticles: Radiation-Assisted Green Synthesis and Drug-Controlled Release Studies

et al. 2023

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This work aims to apply water radiolysis-mediated green synthesis of amphiphilic core–shell water-soluble chitosan nanoparticles (WCS NPs) via free radical graft copolymerization in an aqueous solution using irradiation. Robust grafting poly(ethylene glycol) monomethacrylate (PEGMA) comb-like brushes were established onto WCS NPs modified with hydrophobic deoxycholic acid (DC) using two aqueous solution systems, i.e., pure water and water/ethanol. The degree of grafting (DG) of the robust grafted poly(PEGMA) segments was varied from 0 to ~250% by varying radiation-absorbed doses from 0 to 30 kGy. Using reactive WCS NPs as a water-soluble polymeric template, a high amount of DC conjugation and a high degree of poly(PEGMA) grafted segments brought about high moieties of hydrophobic DC and a high DG of the poly(PEGMA) hydrophilic functions; meanwhile, the water solubility and NP dispersion were also markedly improved. The DC-WCS-PG building block was excellently self-assembled into the core–shell nanoarchitecture. The DC-WCS-PG NPs efficiently encapsulated water-insoluble anticancer and antifungal drugs, i.e., paclitaxel (PTX) and berberine (BBR) (~360 mg/g). The DC-WCS-PG NPs met the role of controlled release with a pH-responsive function due to WCS compartments, and they showed a steady state for maintaining drugs for up to >10 days. The DC-WCS-PG NPs prolonged the inhibition capacity of BBR against the growth of S. ampelinum for 30 days. In vitro cytotoxicity results of the PTX-loaded DC-WCS-PG NPs with human breast cancer cells and human skin fibroblast cells proved the role of the DC-WCS-PG NPs as a promising nanoplatform for controlling drug release and reducing the side effects of the drugs on normal cells.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

pH-Responsive Water-Soluble Chitosan Amphiphilic Core–Shell Nanoparticles: Radiation-Assisted Green Synthesis and Drug-Controlled Release Studies

et al. 2023

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“…Aside from its required effects, Imatinib's active component, everolimus, may produce certain undesirable side effects as well. Even though not all of these adverse effects may occur, if they do, one should get medical care right away to avoid further complications [13].…”

Section: Mechanism Of Action Of Imatinibmentioning

confidence: 99%

An investigation of the anti-cancer drugs imatinib and thalidomide was conducted using analytical spectroscopy and molecular docking techniques

Ramana,

Krishna,

Mouli

2024

Preprint

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Cancer stands as one of the most devastating illnesses in contemporary society, leading to a considerable number of fatalities annually. Effectively managing the disease has been a challenge, partly due to the diverse variants of the disease prevalent in different parts of the world. Despite these challenges, scientific advancements have led to the development of various drugs and diagnostic techniques tailored for specific cancers, offering partial solutions in the quest for a cure. The ongoing exploration of cancer's medical ramifications remains a captivating and vital area of interest, even in light of the extensive efforts expended in scientific research over the years. In this significant study, the research focuses on exploring specific vibrational patterns of Imatinib and Thalidomide through standard FT-IR spectroscopic studies and molecular docking computations. The investigation successfully pinpointed precise atomic-level interactions between the anti-cancer agent Imatinib and the target proteins, namely Tyrosine Kinase Sh2 Domain and Tyrosine-Protein Kinase ABL1, and the cancerous drug Thalidomide and Cereblon Isoform 4 protein. To understand the molecule's bioactivity and the transfer of charges between its outermost orbitals, the UV-Vis spectra of the drugs were scrutinized. Quantum mechanical energy-wavelength conversions were employed to assess the appropriate energy gaps. Moreover, the molecular docking analyses involving Imatinib and Thalidomide and the corresponding respective binding proteins provided crucial insights, including binding affinity, RMSD (Root Mean Square Deviation), types of interactions established as well as the unique pathways that the agent and receptors have developed. The revelations in comprehending the behaviour of anticancer agents represent invaluable contributions to the advancement of our understanding in the field. These findings not only enhance the efficacy of existing treatments but also play a pivotal role in steering the development of pioneering anticancer drugs. The significance of such discoveries cannot be overstated, as they contribute substantially to the ongoing progress in cancer research, offering promising avenues for the improvement of therapeutic interventions and the eventual development of more effective and targeted anticancer medications.

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“…2). It is semi-synthetically developed to also prevent restenosis (Burke et al 2006;Vedantham et al 2010). Zotarolimus has a shorter in vivo half-life with potency that is comparable to that of rapamycin (Chen et al 2007).…”

Section: Chemical Structure Of Rapamycin and Its Analogues (Rapalogues)mentioning

confidence: 99%

Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment

Mohamed

Elkhateeb

Daba

2022

Bioresour. Bioprocess.

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Although celebrating its golden jubilee, rapamycin’s importance keeps increasing by the day. Starting as a promising antifungal agent, then as a potent immunosuppressant, strong anticancer drug, and now rapamycin is attracting serious attention as a rejuvenative agent and a possible contributor in treating this era pandemic, COVID-19. Due to its diverse biological activities and promising medical applications, we aimed in this review to put rapamycin under the spot and highlight its discovery, famous microbial producers, reported biological activities, chemical structure, famous analogues, and biosynthesis. Moreover, discuss some rapamycin production approaches including solid-state fermentation, and stressing out producing strain. On the other hand, describe its action mechanism and trials to use it in treatment of COVID-19. Additionally, we highlighted some of the side effects accompanying its use, and describe some approaches reported to minimize these undesired effects. Finally, we report the current status of rapamycin and its analogues in global market, and discuss future prospects of this potent drug.

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Future outlook for drug eluting stents

Cited by 7 publications

References 156 publications

pH-Responsive Water-Soluble Chitosan Amphiphilic Core–Shell Nanoparticles: Radiation-Assisted Green Synthesis and Drug-Controlled Release Studies

pH-Responsive Water-Soluble Chitosan Amphiphilic Core–Shell Nanoparticles: Radiation-Assisted Green Synthesis and Drug-Controlled Release Studies

An investigation of the anti-cancer drugs imatinib and thalidomide was conducted using analytical spectroscopy and molecular docking techniques

Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment

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