Future Perspectives: Microbiome, Cancer and Therapeutic Promise

Banerjee, Sagarika; Robertson, Erle S.

doi:10.1007/978-3-030-04155-7_17

Cited by 6 publications

(3 citation statements)

References 190 publications

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“…The term ‘microbiota’ is used to refer to the group of microorganisms associated to a specific biologic niche ( Banerjee and Robertson, 2019 ). The human microbiota is composed of 500-1000 bacterial species, with genomes containing thousands of genes, which offers a much greater diversity and genetic versatility than the human genome ( Locey and Lennon, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Urinary Microbiome: Yin and Yang of the Urinary Tract

Pérez-Carrasco

Soriano‐Lerma

Soriano

et al. 2021

Front. Cell. Infect. Microbiol.

137

119

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The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Urinary Microbiome: Yin and Yang of the Urinary Tract

Pérez-Carrasco

Soriano‐Lerma

Soriano

et al. 2021

Front. Cell. Infect. Microbiol.

137

119

View full text Add to dashboard Cite

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“…The term 'microbiota' denotes the collection of microorganisms residing in a specific biological environment, including bacteria, viruses, parasites, and fungi [10]. The mammalian gastrointestinal tract hosts a complex community of trillions of symbiotic entities, such as bacteria, fungi, archaea, and viruses, collectively known as the GM [11].…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota in patients with prostate cancer: a systematic review and meta-analysis

Huang,

Liu,

Wen

et al. 2024

BMC Cancer

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Background Increasing evidence indicates that gut microbiota are closely related to prostate cancer. This study aims to assess the gut microbiota composition in patients with prostate cancer compared to healthy participants, thereby advancing understanding of gut microbiota's role in prostate cancer. Methods A systematic search was conducted across PubMed, Web of Science, and Embase databases, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of included studies was evaluated using the Newcastle–Ottawa Scale (NOS), and pertinent data were analyzed. The kappa score assessed interrater agreement. Results This study encompassed seven research papers, involving 250 prostate cancer patients and 192 controls. The kappa was 0.93. Meta-analysis results showed that alpha-diversity of gut microbiota in prostate cancer patients was significantly lower than in the control group. In terms of gut microbiota abundance, the ratio of Proteobacteria, Bacteroidia, Clostridia, Bacteroidales, Clostridiales, Prevotellaceae, Lachnospiraceae, Prevotella, Escherichia-Shigella, Faecalibacterium, and Bacteroides was higher in prostate cancer patients. Conversely, the abundance ratio of Actinobacteria, Bacteroidetes, Firmicutes, Selenomonadales, Veillonella, and Megasphaera was higher in the control group. Conclusion Our study reveals differences in alpha-diversity and abundance of gut microbiota between patients with prostate cancer and controls, indicating gut microbiota dysbiosis in those with prostate cancer. However, given the limited quality and quantity of selected studies, further research is necessary to validate these findings.

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“…The term "microbiota" refers to the entire set of microorganisms found in a definite biologic niche. 1 Present evidence states that each human cell is associated with approximately ten bacterial cells forming a giant ecosystem thereby contributing towards the physiological functions of the human body such as vitamin K production, its role in clotting mechanism and also to the development of immunity. 2 Human microbiota is composed of virus, fungi, protozoa, archaea in addition to bacteria.…”

Section: Introductionmentioning

confidence: 99%

Unlocking The Human Urobiome: Impact On Health and Disease- A Review

Ramalingam

Khan

Manonmoney

et al. 2022

Int J Life Sci Pharm Res

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The urinary microbiome or the urobiome are the group of microbes present in the urinary tract. They came into the limelight in the last decade due to advances in diagnostic technologies. Two complementary assays are widely used for research in urobiomes. Next-generation sequencing (NGS) of 16S ribosomal RNA (rRNA) paired with enhanced urine culture techniques (EUCT) are widely employed for research. This has paved the way for investigations on sterile body sites such as urine thereby breaking the myth of urine being considered sterile. EUCT, such as expanded quantitative urine culture (EQUC) contributed to the evidence that the microbes detected by the NGS are still alive. EQUC has been employed in clinical laboratories since the last decade and is indicated only when there are unexplained clinical symptoms and conventional urine culture is negative. Our aim is to have a comprehensive review study on the urobiome concerning health, its association with urological pathologies. Our main objective is to collect review and research articles using databases and review them for obtaining in-depth knowledge of the urobiome as well as to identify possible alternate study areas. The urobiome is a new area with minimal information available. This review helps the researcher to comprehend this upcoming area easily. Investigations into urobiome research, however, could have a considerable impact on our understanding of the pathogenesis of urogenital disorders and even reveal novel possibilities. Thus, the forthcoming years will open a ripe ground for future research into diagnosis, treatment and prevention strategies for urological pathologies.

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Future Perspectives: Microbiome, Cancer and Therapeutic Promise

Cited by 6 publications

References 190 publications

Urinary Microbiome: Yin and Yang of the Urinary Tract

Urinary Microbiome: Yin and Yang of the Urinary Tract

Gut microbiota in patients with prostate cancer: a systematic review and meta-analysis

Unlocking The Human Urobiome: Impact On Health and Disease- A Review

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