Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

Boixeda, P.; Feltes, F.; Santiago, Juan Luis; Paoli, John

doi:10.1016/j.adengl.2015.01.002

Cited by 9 publications

(16 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Assessment of primary melanomas on the surface of the skin has also been proven to be difficult with conventional MRI, CT, and PET scanning. [Boixeda et al, ].…”

Section: Introductionmentioning

confidence: 99%

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Vilagosh

Lajevardipour

Wood

2019

Bioelectromagnetics

View full text Add to dashboard Cite

Terahertz radiation (THz) is highly absorbed by liquid water. This creates the possibility of medical imaging on the basis of the water content difference between normal and diseased tissue. The effective penetration of THz is limited, however, to a tissue depth of 0.2–0.3 mm at body temperature. A unique feature of the 0.1–2.0 THz frequency is that there is a high disparity between liquid water absorption and ice absorption, with ice being 100 times more permeable to the radiation than liquid water. This results in 90% of the radiation surviving to 1.0 mm in ice, permitting the imaging of frozen tissues to a depth of 5.0 mm. This method is practical as an in vivo procedure before or during surgical excision. Finite difference time domain (FDTD) computational modeling of frozen normal skin and frozen melanoma was undertaken using tissue phantoms. The study suggests that sufficient contrast exists to differentiate normal frozen skin and melanoma on the basis of the difference of water content alone. When the melanin pigment in melanomas is modeled as a significant absorber of THz, the contrast changes. Based on the modeling, further exploration of the “THz‐skin freeze” imaging technique is justified. In the modeling, the boundary between the frozen tissue and non‐frozen tissue is shown to be strongly reflective. If the reflective properties of the boundary are substantiated, the “THz‐skin freeze” technique will have applications in other areas of skin diagnostics and therapeutics. Bioelectromagnetics. 40:118–127, 2019. © 2019 Bioelectromagnetics Society

show abstract

“…Assessment of primary melanomas on the surface of the skin has also been proven to be difficult with conventional MRI, CT, and PET scanning. [Boixeda et al, ].…”

Section: Introductionmentioning

confidence: 99%

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Vilagosh

Lajevardipour

Wood

2019

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…Nanodermatology-based solutions (Boixeda, Feltes, Santiago, & Paoli, 2015;Dadwal, Mishra, & Narang, 2018;DeLouise, 2012;Palmer & DeLouise, 2016;Rahman et al, 2015;Saraceno, Chiricozzi, Gabellini, & Chimenti, 2013) appear promising for the proper diagnosis, treatment, and management of psoriasis, a disease with a worldwide prevalence of 2-3%, which poses a significant burden on patients and more generally on society. Available studies are focused on the use of nanotechnology-based drug delivery for immunomodulating drugs only.…”

Section: Discussionmentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale (“skin nanobiology”), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies (“nanodiagnosis”), and (c) treatment through innovative therapeutic agents, including phototherapy (“photonanotherapy”/“photonanodermatology”) and systemic/topical drug administration (“nanotherapy”) at the nanoscale, and drug delivery—such as transdermal or dermal drug delivery (TDDD/DDD)—enhanced and improved by nanostructures and nanodrugs (“nanodrug delivery”). Nanodermatology, as a super‐specialized branch of dermatology, is a quite recent specialty: the “Nanodermatology Society” founded by the eminent dermatologist Dr. Adnan Nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy‐makers and regulators, as well as students and medical residents. Psoriasis has a prevalence of 2–3% worldwide and imposes a severe clinical and societal burden. Nanodermatology‐based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health‐care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

show abstract

“…at the nanoscale (1-1000 nm). Hence, nanotechnology can be defined as methods or techniques employed in the processing of materials at the atomic or sub-atomic scale to generate products with physical and chemical properties that are different to the traditional counterparts [122,123]. Nanomedicine, on the other hand, is the application of nanotechnology in medicine or health care.…”

Section: Nanotechnology/nanomedicinementioning

confidence: 99%

“…Nanomedicine, on the other hand, is the application of nanotechnology in medicine or health care. Recently, it has become possible to create nanoparticles that can function in an organized manner as biological sensors for the early detection, monitoring and treatment/management of diseases [122]. Nanomedicine has provided novel ways of diagnosis and treatment of dermatological conditions.…”

Section: Nanotechnology/nanomedicinementioning

confidence: 99%

Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

Adeola¹,

Wyk²,

Arowolo³

et al. 2018

Keratin

View full text Add to dashboard Cite

Minimally and noninvasive investigation of pathology and treatment monitoring is highly attractive in medicine. The use of human hair samples as a non-invasive testing substrate is potentially poised to improve diagnostic and forensic medicine. Hair has the unique ability to capture long-term information about health and disease in an individual as compared to urine and blood. Testing long hair offers a potential means of long-term monitoring of drug compliance, drug abuse, chronic alcohol abuse, and diagnostic biomarker discovery. Even though human hair is mostly composed of keratin and keratin-associated proteins, very little literature has been published on human hair proteomics. Emerging high throughput omics based techniques such as proteomics are increasingly improving our depth of knowledge about the diagnosis, prognosis and prediction of diseases globally. Although many aspects of the use of these novel molecular aids to improve disease diagnosis and patient management remains elusive; it is evident that these techniques have improved precision medicine tremendously. This chapter aims to discuss current plausible application of human hair omics-based approaches to the field of pathology, diagnostics and precision/individualized medicine.

show abstract

Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

Cited by 9 publications

References 104 publications

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Human Hair as a Testing Substrate in the Era of Precision Medicine: Potential Role of ‘Omics-Based Approaches

Contact Info

Product

Resources

About