Future Strategies for the Development of Desensitising Products

Hill, Robert G.; Gillam, DG

doi:10.1007/978-3-319-14577-8_11

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Moreover, the fluoride ions can either aid in the conversion of OCP to apatite or result in direct apatite formation. Therefore, OCP has an attractive potential for remineralization since OCP can incorporate a source of fluoride for catalyzing the transformation of OCP to apatite and for the formation of a more acid-durable fluoridated apatite [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Cruz

Hill

Chen

et al. 2018

International Journal of Dentistry

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There are numerous over-the-counter (OTC) and professionally applied (in-office) products and techniques currently available for the treatment of dentine hypersensitivity (DH), but more recently, the use of bioactive glasses in toothpaste formulations have been advocated as a possible solution to managing DH. Aim. The aim of the present study, therefore, was to compare several bioactive glass formulations to investigate their effectiveness in an established in vitro model. Materials and Methods. A 45S5 glass was synthesized in the laboratory together with several other glass formulations: (1) a mixed glass (fluoride and chloride), (2) BioMinF, (3) a chloride glass, and (4) an amorphous chloride glass. The glass powders were formulated into five different toothpaste formulations. Dentine discs were sectioned from extracted human teeth and prepared for the investigation by removing the cutting debris (smear layer) following sectioning using a 6% citric acid solution for 2 minutes. Each disc was halved to provide test and control halves for comparison following the brushing of the five toothpaste formulations onto the test halves for each toothpaste group. Following the toothpaste application, the test discs were immersed in either artificial saliva or exposed to an acid challenge. Results. The dentine samples were analyzed using scanning electron microscopy (SEM), and observation of the SEM images indicated that there was good surface coverage following artificial saliva immersion. Furthermore, although the acid challenge removed the hydroxyapatite layer on the dentine surface for most of the samples, except for the amorphous chloride glass, there was evidence of tubular occlusion in the dentine tubules. Conclusions. The conclusions from the study would suggest that the inclusion of bioactive glass into a toothpaste formulation may be an effective approach to treat DH.

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Section: Discussionmentioning

confidence: 99%

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Cruz

Hill

Chen

et al. 2018

International Journal of Dentistry

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“…NovaMin® particles have a hardness value high above the hardness value of dentin and also to that of enamel. In terms of abrasive wear during tooth brushing, it would be desirable to have a glass that is lower to the hardness values of natural enamel in order to minimize the loss of enamel [36]. The experimental particles in the present study, which were obtained by acid-base reactions, result in highly porous materials.…”

Section: Discussionmentioning

confidence: 99%

Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin

et al. 2018

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“…Bioglass formulation initially form an octa calcium phosphate (OCP) phase which is found to be a precursor for hydroxyapatite formation. OCP has an attractive remineralization potential that it can incorporate a fluoride source and promotes the transformation of OCP to apatite and also acid-durable fluoridated apatite could be formed ( Hill & Gillam, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative assessment of enamel remineralisation on the surface microhardness of demineralized enamel - anin vitrostudy

Bhavsar

Vijo

Sharma

et al. 2022

PeerJ

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Objective The main objective of the study was to compare two different remineralising materials containing casein phosphopeptide-amorphous calcium phosphate, bioactive glass on enamel surface microhardness. Materials and Methods Thirty premolars were used for specimen preparation. Group 1 (the control group) consisted of intact enamel samples, group 2: CPP-ACPF (Tooth Mousse Plus), group 3: bioenamel remineralising gel (Prevest DenPro). All specimens were subjected to demineralisation except the control group, followed by which remineralising agents were applied. A universal hardness tester was used to assess the surface microhardness of all samples. Results were analysed using one-way ANOVA test and comparison was analysed using Scheffe’s post hoc least significant difference (LSD) test. Results Both remineralising agents used in groups 2 and 3 have shown significant outcome in terms of improving the surface microhardness in comparison with the control group. Group 2 increased the enamel hardness by 8.34 where P = 0.023 whereas group 3 increased the hardness by 5.87, where P = 0.01. Conclusion Group 2 has a superior hardness value than group 3; however, no statistically significant results were obtained between both the groups.

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Future Strategies for the Development of Desensitising Products

Cited by 6 publications

References 25 publications

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Dentine Tubule Occlusion by Novel Bioactive Glass-Based Toothpastes

Zinc and silica are active components to efficiently treat in vitro simulated eroded dentin

Comparative assessment of enamel remineralisation on the surface microhardness of demineralized enamel - anin vitrostudy

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