2015
DOI: 10.1161/cir.0000000000000211
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Future Translational Applications From the Contemporary Genomics Era

Abstract: The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardiovascular clinical… Show more

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Cited by 37 publications
(26 citation statements)
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References 145 publications
(129 reference statements)
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“…18,19 A more detailed review of genetic and genomic concepts in CVD, is found in an AHA Scientific Statement. 20 IHD is considered a complex, multifactorial disease because it is influenced by multiple genes and the environment.…”
Section: Scope Of the Problem: Epidemiology Of Ihd In Womenmentioning
confidence: 99%
“…18,19 A more detailed review of genetic and genomic concepts in CVD, is found in an AHA Scientific Statement. 20 IHD is considered a complex, multifactorial disease because it is influenced by multiple genes and the environment.…”
Section: Scope Of the Problem: Epidemiology Of Ihd In Womenmentioning
confidence: 99%
“…16,36,63-65 Recent studies have demonstrated that genetic variants may be causal in human diseases by inducing aberrant splicing through altering the splicing code (see above), 29,30,66 so we evaluated whether the iPSDM system can be a model for studying AS events. We analyzed RNA-seq data for M1-iPSDM and M2-iPSDM activation (derived from the same donors contributing to HMDM RNA-seq, Figure 1A) to determine if iPSDM cellular models recapitulated the AS profiles for M1-HMDMs and M2-HMDMs.…”
Section: Resultsmentioning
confidence: 99%
“…130 Additionally, the American Heart Association has published several policy statements and guidelines for application of genetics to the care of children and adults with heart disease. 20,[131][132][133] These efforts provide resources to guide incorporation of genetics and genomics into the practice of cardiovascular health care. Several general and specialtyspecific resources available to practitioners are listed in Table 9.…”
Section: Mital Et Al Enhancing Literacy In Cardiovascular Genetics 461mentioning
confidence: 99%