“…Quantitative microbial risk assessment techniques (Pujol et al, 2013) Semi-quantitative risk determination approach (Pazhayattil et al, 2020) Integrated evaluation methods combining qualitative and quantitative methods Analytic hierarchy process (Ishizaka et al, 2011;Lyu et al, 2020) When there are too many risk factors affecting drug safety, it is easy to cause confusion in the scale and too many qualitative components are not convincing Fuzzy comprehensive evaluation method (Li et al, 2016;Lin et al, 2018;Zhang et al, 2021) The calculation is complex and the determination of the indicator weight vector is highly subjective Dempster-shafer evidence theory (Brodzik and Enders, 2009;Dempster, 1967;Wang et al, 2002) It is required that the factors affecting drug production safety are independent and are prone to exponential explosions during calculation Analytic Network Process (Ceric et al, 2013;Kop et al, 2011;Shafiee et al, 2019;Stepchenko and Voronova, 2015;Wang et al, 2018;Yazdani et al, 2019) Combine with process analysis method (Neum€ uller et al, 2015) Analytic Network Process takes into account the interaction between different levels and the interaction between the same level on the basis of the analytic hierarchy process, but it often encounters the problem of uncertain information in the process of risk assessment Combine with interval-valued intuitionistic fuzzy environment (Yang et al, 2020) Combine with triangular fuzzy numbers (Balogun et al, 2021) Grey system theory (Deng, 2008;Li and Wei, 2018;Liu et al, 2009Liu et al, , 2013aOzcan and Tuysuz, 2016) Often used in situations with incomplete information or low data quality The remainder of the paper is organized as follows: Section 3 investigates research methodologies for establishing the drug production safety risk evaluation index system, calculating index weights and determining grey evaluation matrix. Section 4 conducts an empirical study for a drug production enterprise, carrying out numerical analysis and results and examining the validity of the proposed gray network an...…”