FXR and liver carcinogenesis

Huang, Xiongfei; Zhao, Weiliang; Huang, Wendong

doi:10.1038/aps.2014.117

Cited by 68 publications

(64 citation statements)

References 93 publications

(154 reference statements)

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“…Besides the intestinal system, kidneys, liver or adrenal glands, FXR exhibits a low expression level in the stomach, heart, lung and fat tissue (9,11,12,(27)(28)(29). In the present study, we observed FXR expression at a significantly lower level in cultured human GES-1 gastric mucosa cells and assessed the functional connection between bile acid-FXR pathway and intestinal metaplasia of gastric mucosa cells.…”

Section: Discussionmentioning

confidence: 51%

Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells

Chen

Zhou

et al. 2015

Oncology Reports

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Abstract. The farnesoid X receptor (FXR) signaling pathway is known to be involved in the metabolism of bile acid, glucose and lipid. In the present study, we demonstrated that 400 µmol/l deoxycholic acid (DCA) stimulation promotes the proliferation of normal human gastric epithelial cells (GES-1). In addition, DCA activated FXR and increased the expression of intestinal metaplasia genes, including caudal-related homeobox transcription factor 2 (Cdx2) and mucin 2 (MUC2). The treatment of FXR agonist GW4064/antagonist guggulsterone (Gug.) significantly increased/decreased the expression levels of FXR, Cdx2 and MUC2 protein in DCA-induced GES-1 cells. GW4064/Gug. also enhanced/reduced the nuclear factor-κB (NF-κB) activity and binding of the Cdx2 promoter region and NF-κB, the most common subunit p50 protein. Taken together, the results indicated that DCA is capable of modulating the expression of Cdx2 and the downstream MUC2 via the nuclear receptor FXR-NF-κB activity in normal gastric epithelial cells. FXR signaling pathway may therefore be involved in the intestinal metaplasia of human gastric mucosa.

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Section: Discussionmentioning

confidence: 51%

Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells

Chen

Zhou

et al. 2015

Oncology Reports

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“…Beside androgen receptor and estrogen receptor, the two of classical steroid hormone receptors in cancers, orphan nuclear receptors COUPTFs also known to play important role in tumorigenesis, and they are respectively reviewed by Xu and coworkers [3] . In addition, the roles of bile acid receptor FXR in liver cancer will be reviewed by Huang and coworkers [4] . Nuclear hormone receptors are also well known for their central roles in metabolic regulation.…”

Section: Editorialmentioning

confidence: 99%

Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

2015

Acta Pharmacol Sin

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EditorialHormones comprise one of the most effective classes of messengers that transmit cell to cell communication in eukaryotic systems. Cells receive messages of hormones through protein receptors, and then translate the hormone signals into concrete action of physiological responses. Homeostasis of hormone systems is essential for human health, and aberrant regulation of hormone signaling has been associated with many diseases, including cancer, diabetes, and inflammation diseases. As such, targeting hormone signaling pathways has become a major venue of pharmacological intervention of many health abnormalities. There are two major classes of hormone receptors: G-protein coupled receptors and nuclear hormone receptors, both of which consist of the top two classes of the most successful drug targets. Two years ago, we published a special issue on structures, biology and drug discovery of G-protein coupled receptors, which has been well received by drug discovery research communities. This year marked the 30th anniversary of the cloning of the first member of the nuclear receptor family and 25th year of the discovery of orphan nuclear receptors, for which no cognate ligands were known at the time of their cloning. Since then we have witnessed a tremendous expansion of our knowledge of this family of receptors. In this special issue, we collected eleven exciting review articles, highlighting our current understanding of structure, function, disease relevance, and drug discovery of nuclear receptors.Hormones androgen and estrogen have long been known to play key roles in development, growth, and homeostasis of reproductive systems and their dysregulation is the major cause of prostate cancer and breast cancer. The first article by Tan and coworkers will provide comprehensive review on structures, diseases relevance and drug discovery of androgen receptor, the oncogenic driver of prostate cancer [1] . The second review article by Ikeda and coworkers covers the roles of estrogen-responsive genes in breast cancer [2] . Beside androgen receptor and estrogen receptor, the two of classical steroid hormone receptors in cancers, orphan nuclear receptors COUPTFs also known to play important role in tumorigenesis, and they are respectively reviewed by Xu and coworkers [3] . In addition, the roles of bile acid receptor FXR in liver cancer will be reviewed by Huang and coworkers [4] . Nuclear hormone receptors are also well known for their central roles in metabolic regulation. Classic examples are peroxisome proliferator activated receptors (PPARs) and receptors for glucocorticoids and thyroid hormone, for which roles have been well reviewed in the literatures. In this special issue, we will focus on the emerging roles of orphan nuclear receptors in metabolism. Jiao and coworkers review the regulatory role of FXR in homeostasis of hepatic triglyceride [5] . Audet-wash and Giguère review the roles of estrogen-related receptor α and γ in metabolic control and related diseases [6] . Yan and Xie review the role of constitutive...

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“…The red emission is weak in the Er 3 þ /Yb 3 þ co-doped oxyfluoride glass ceramic microspheres [27], but it is significantly enhanced when Tm 3 þ is introduced into the system. It indicates that the red emission centered at 651 nm is the superposition of the two routes mentioned below: one originates from Tm 3 þ : 1 G 4 -3 F 4 transition.…”

Section: Resultsmentioning

confidence: 98%

“…The total stretched length was about 4-4.5 cm. Details of the fabrication of tapered fiber are given elsewhere [16,27,28].…”

Section: Methodsmentioning

confidence: 99%

High efficiency white luminescence in Tm3+/Er3+/Yb3+ tri-doped oxyfluoride glass ceramic microsphere pumped by 976 nm laser

Huang

et al. 2015

Journal of Luminescence

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FXR and liver carcinogenesis

Cited by 68 publications

References 93 publications

Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells

Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells

Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

High efficiency white luminescence in Tm3+/Er3+/Yb3+ tri-doped oxyfluoride glass ceramic microsphere pumped by 976 nm laser

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