Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer

Nisar, Asif; Kayani, Mahmood Akhtar; Nasir, Wajiha; Mehmood, Azhar; Ahmed, Malik Waqar; Parvez, Aamir; Mahjabeen, Ishrat

doi:10.1007/s00438-022-01946-7

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…However, the other gene located in the same LD block as CABYR , LYN , which belongs to the Src family of intracellular membrane-associated tyrosine kinases, is an important candidate gene for growth traits in many farm animals. Like most genes regulating growth traits, LYN plays an essential role in the occurrence and development of cancers [ 26 – 28 ] since it can function in the signal transduction of growth factor receptors [ 29 ]. LYN is a vital candidate gene affecting human height [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of the genetic basis of the duck growth rate in multiple growth stages using genome-wide association analysis

Yang

Zeng

et al. 2023

BMC Genomics

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Background The genetic locus responsible for duck body size has been fully explained before, but the growth trait-related genetic basis is still waiting to be explored. For example, the genetic site related to growth rate, an important economic trait affecting marketing weight and feeding cost, is still unclear. Here, we performed genome wide association study (GWAS) to identify growth rate-associated genes and mutations. Result In the current study, the body weight data of 358 ducks were recorded every 10 days from hatching to 120 days of age. According to the growth curve, we evaluated the relative and absolute growth rates (RGR and AGR) of 5 stages during the early rapid growth period. GWAS results for RGRs identified 31 significant SNPs on autosomes, and these SNPs were annotated by 24 protein-coding genes. Fourteen autosomal SNPs were significantly associated with AGRs. In addition, 4 shared significant SNPs were identified as having an association with both AGR and RGR, which were Chr2: 11483045 C>T, Chr2: 13750217 G>A, Chr2: 42508231 G>A and Chr2: 43644612 C>T. Among them, Chr2: 11483045 C>T, Chr2: 42508231 G>A, and Chr2: 43644612 C>T were annotated by ASAP1, LYN and CABYR, respectively. ASAP1 and LYN have already been proven to play roles in the growth and development of other species. In addition, we genotyped every duck using the most significant SNP (Chr2: 42508231 G>A) and compared the growth rate difference among each genotype population. The results showed that the growth rates of individuals carrying the Chr2: 42508231 A allele were significantly lower than those without this allele. Moreover, the results of the Mendelian randomization (MR) analysis supported the idea that the growth rate and birth weight had a causal effect on the adult body weight, with the growth rate having a greater effect size. Conclusion In this study, 41 SNPs significantly related to growth rate were identified. In addition, we considered that the ASAP1 and LYN genes are essential candidate genes affecting the duck growth rate. The growth rate also showed the potential to be used as a reliable predictor of adult weight, providing a theoretical reference for preselection.

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Section: Discussionmentioning

confidence: 99%

Identification of the genetic basis of the duck growth rate in multiple growth stages using genome-wide association analysis

Yang

Zeng

et al. 2023

BMC Genomics

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“…The Lyn gene belongs to the Src kinase family and is on chromosome 8q13. Lyn gene is a primary regulator of various signal transduction pathways and is involved in the occurrence of a variety of malignant tumors [14]. BTK is a potent oncogene that plays a role in the downstream RAS/MAPK pathway and is essential for RAS-mediated transformation [15].…”

Section: Discussionmentioning

confidence: 99%

Clinical and molecular characteristics, transcriptome, and drug efficacy of ERBB2 tyrosine kinase and non-tyrosine kinase mutations in non-small cell lung cancer

Zheng

Ying

et al. 2023

Preprint

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ERBB2 mutations in the tyrosine kinase domain (TKD) have been widely reported in non-small cell lung cancer (NSCLC). More and more non-tyrosine kinase domain (non-TKD) mutations of ERBB2 have been detected. However, the clinical effects of non-TKD mutations are still unknown. Therefore, this study aims to study the molecular and clinical characteristics, transcriptome differences, and sensitive drugs of TKD and non-TKD mutations in NSCLC. Gene mutation, RNA sequencing, and clinical information of NSCLC with ERBB2 mutations were downloaded. Bioinformatics methods, such as gene mutation analysis, differentially expressed genes (DEGs), functional enrichment analysis, protein-protein interaction (PPI), hub gene identification, and drug sensitivity analysis, were adopted. Finally, four patients were included to reflect the treatment response. The somatic mutation rate of ERBB2 was 3.2%. TKD and non-TKD mutations mainly occurred in lung adenocarcinoma. Non-TKD mutations have a better prognosis. Up-regulated DEGs are primarily involved in immune and inflammatory pathways. We then proved that BTK, LYN, and PIK3CA mutations have a better prognosis than wild type in patients of NSCLC. The drug sensitivity study found that the TKD group was more sensitive to 5 drugs, and the non-TKD was 28.TKD and non-TKD mutations identify two independent subsets of ERBB2 mutations in NSCLC. Non-TKD mutations have a better prognosis and can also be used as targets for ERBB2. Our study can provide a foundation for further clinical research, highlighting the importance of individualized treatment for patients with different mutation domains.

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“…Proto‐oncogene tyrosine‐protein kinase (FYN) belongs to the SRC family of kinases (SFKs) and acts as an oncogene in multiple cancers. 17 , 18 Furthermore, it has been demonstrated that high expression of FYN in EC promoted EC tumorigenesis. 19 , 20 However, the detailed function of FYN in EC is unclear.…”

Section: Introductionmentioning

confidence: 99%

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

Chu,

Sun,

Liu

et al. 2024

Thoracic Cancer

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BackgroundCircular RNAs (circRNAs) play critical roles in the tumorigenesis and radiosensitivity of multiple cancers. Nevertheless, the biological functions of circRNA periostin (circ‐POSTN) in esophageal cancer (EC) progression and radiosensitivity have not been well elucidated.MethodsThe expression of circ‐POSTN, microRNA‐876‐5p (miR‐876‐5p), and proto‐oncogene tyrosine‐protein kinase (FYN) was analyzed by quantitative reverse transcription PCR (RT‐qPCR). Cell proliferation was assessed by MTT, colony formation, and 5‐ethynyl‐2′‐deoxyuridine (EDU) assays. All protein levels were detected by western blot assay. Cell apoptosis and invasion were assessed by flow cytometry analysis and transwell assay, respectively. Dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays were used to validate the interaction between miR‐876‐5p and circ‐POSTN or FYN. The role of circ‐POSTN in vivo was explored by establishing mice xenograft model.ResultsCirc‐POSTN was overexpressed in EC tissues and cells. Knockdown of circ‐POSTN inhibited cell proliferation and invasion and elevated apoptosis and radiosensitivity in EC cells. MiR‐876‐5p was a direct target of circ‐POSTN, and its knockdown reversed the role of sh‐circ‐POSTN in EC cells. FYN was a direct target of miR‐876‐5p, and FYN elevation weakened the effects of miR‐876‐5p overexpression on the progression and radiosensitivity of EC cells. Moreover, circ‐POSTN acted as a miR‐876‐5p sponge to regulate FYN expression. Circ‐POSTN interference also suppressed tumor growth and enhanced radiosensitivity in vivo.ConclusionCirc‐POSTN knockdown inhibited proliferation and invasion, but increased apoptosis and enhanced radiosensitivity in EC cells via modulating miR‐876‐5p/FYN axis, which might be a potential diagnostic and therapeutic target for EC.

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Fyn and Lyn gene polymorphisms impact the risk of thyroid cancer

Cited by 7 publications

References 51 publications

Identification of the genetic basis of the duck growth rate in multiple growth stages using genome-wide association analysis

Identification of the genetic basis of the duck growth rate in multiple growth stages using genome-wide association analysis

Clinical and molecular characteristics, transcriptome, and drug efficacy of ERBB2 tyrosine kinase and non-tyrosine kinase mutations in non-small cell lung cancer

Circ‐POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR‐876‐5p/FYN axis

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