G-CSF-producing Undifferentiated Pleomorphic Sarcoma Adjacent to the Ascending Colon and in the Right Iliopsoas Muscle: A Case Report and Review of the Literature

Kazama, Shinsuke; Gokita, Tabu; Takano, Michitoshi; Ishikawa, Ayataka; Nishimura, Y; Ishii, Hiroaki; Nishizawa, Yusuke; Nishimura, Yuichi; Kawashima, Yasunaru; Sakamoto, Hirohiko

doi:10.2169/internalmedicine.2762-19

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…There have been only a few cases of UPS in the gastrointestinal tract according to the diagnostic criteria after the WHO 2013 reclassi cation [4][5][6][7][8][9][10][11], and this is the second case with perforation of the gastrointestinal tract [4]. UPS lacks characteristic physical symptoms and imaging ndings.…”

Section: Discussionmentioning

confidence: 99%

Surgical Resection of Undifferentiated Pleomorphic Sarcoma (UPS) With Jejunal Perforation, A Suspected Case of Metastasis of Lung Cancer: A Case Report

Eto

Hoshino

Takiguchi

et al. 2021

Preprint

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Background: Undifferentiated pleomorphic sarcoma (UPS) in the gastrointestinal tract is rare. According to the diagnostic criteria after the World Health Organization 2013 reclassification, there has been only one case of UPS with perforation of the gastrointestinal tract.Case presentation: A 71-year-old man who was undergoing outpatient chemotherapy at the department of respiratory medicine of our hospital for lung cancer and brain metastasis, was admitted to our hospital with sudden high fever and abdominal pain. A computed tomography scan showed free air in the abdominal cavity with thickening of part of the jejunal wall. We suspected jejunal metastasis of lung cancer and performed emergency surgery for acute peritonitis due to gastrointestinal perforation in the same area. A Bormann type 2 tumor was found in the jejunum with perforation. The histopathological diagnosis was UPS. Ten months have passed since the surgery, and there has been no recurrence of UPS and no significant change in lung cancer.Conclusions: Primary UPS of the gastrointestinal tract is rare, and cases with perforation are extremely rare. Currently, ten months have passed since the surgery, and no recurrence has been observed. We encountered a case of UPS in which it was difficult to distinguish metastasis from lung cancer to the jejunum, and emergency surgery gave us the chance to confirm the definitive diagnosis and save the patient's life.

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Section: Discussionmentioning

confidence: 99%

Surgical Resection of Undifferentiated Pleomorphic Sarcoma (UPS) With Jejunal Perforation, A Suspected Case of Metastasis of Lung Cancer: A Case Report

Eto

Hoshino

Takiguchi

et al. 2021

Preprint

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“…As UPS/MFH progresses, it mainly spreads to the lungs (82%), lymph nodes (32%), liver (15%) and bones (11%), but rarely to the small intestine or colon. [2] There have been only a few cases of UPS in the gastrointestinal tract according to the diagnostic criteria after the WHO 2013 reclassification [4][5][6][7][8][9][10][11][12] and this is the second case with perforation of the gastrointestinal tract [4]. UPS lacks characteristic physical symptoms and imaging findings.…”

Section: Discussionmentioning

confidence: 99%

Surgical resection of undifferentiated pleomorphic sarcoma (UPS) with jejunal perforation, a suspected case of metastasis of lung cancer

Eto

Hoshino

Takiguchi

et al. 2021

Clin J Gastroenterol

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Undifferentiated pleomorphic sarcoma (UPS) in the gastrointestinal tract is rare. According to the diagnostic criteria after the World Health Organization 2013 reclassification, there has been only one case of UPS with perforation of the gastrointestinal tract. A 71-year-old man who was undergoing outpatient chemotherapy at the department of respiratory medicine of our hospital for lung cancer and brain metastasis, was admitted to our hospital with sudden high fever and abdominal pain. A computed tomography scan showed free air in the abdominal cavity with thickening of part of the jejunal wall. We suspected jejunal metastasis of lung cancer and performed emergency surgery for acute peritonitis due to gastrointestinal perforation in the same area. A Bormann type 2 tumour was found in the jejunum with perforation. The histopathological diagnosis was UPS. Ten months have passed since the surgery, and there has been no recurrence of UPS and no significant change in lung cancer. Primary UPS of the gastrointestinal tract is rare, and cases with perforation are extremely rare. Currently, ten months have passed since the surgery, and no recurrence has been observed. We encountered a case of UPS in which it was difficult to distinguish metastasis from lung cancer to the jejunum, and the emergency surgery gave us the chance to confirm the definitive diagnosis and save the patient's life.

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“…To our knowledge, only 14 cases of cecal or ascending colon UPS are reported in the literature. [2][3][4][5][6][7][8][9][10][11][12][13][14] The classification and subdivision of these tumors went through several iterations until the World Health Organization 2002 classification eliminated the term MFH and replaced it with UPS. 1 UPSs most commonly occur later in life, usually the sixth and seventh decades, 15 and account for approximately 20% of all soft-tissue sarcomas.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Undifferentiated Pleomorphic Sarcoma of the Cecum

McCombs¹,

Condon²,

Roybal³

et al. 2022

TOJ

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Background: Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm typically diagnosed in older adults and localized to the extremities or retroperitoneum. Because of poor response to therapy and high rates of recurrence, this neoplasm is associated with a poor prognosis. Case Report: A 12-year-old female presented with weight loss, abdominal pain, fatigue, and diarrhea. She was profoundly anemic with occult blood-positive stools. On endoscopy, a fungating cecal mass was biopsied and diagnosed as malignant sarcomatoid neoplasm. The neoplasm was resected with clear margins during subsequent surgery, and on final pathology was diagnosed as UPS. A suspicious lung nodule was also removed via video-assisted thoracoscopic surgery and found to be a granuloma positive for Histoplasma capsulatum for which the patient received antifungal therapy. The patient did not receive additional chemotherapy or radiotherapy and was doing well without signs of recurrence at 12 months postresection. Conclusion: This report of cecal UPS in a 12-year-old is rare because of the patient's age and tumor location. We have identified only 2 other case reports of pediatric gastrointestinal UPS. This case illustrates the need for a broad differential and prompt workup in pediatric patients presenting with weight loss and abdominal complaints. More information regarding the management and outcomes in cases of gastrointestinal UPS is needed to assist providers in determining the best treatment course and to allow for better prognostication.

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G-CSF-producing Undifferentiated Pleomorphic Sarcoma Adjacent to the Ascending Colon and in the Right Iliopsoas Muscle: A Case Report and Review of the Literature

Cited by 9 publications

References 29 publications

Surgical Resection of Undifferentiated Pleomorphic Sarcoma (UPS) With Jejunal Perforation, A Suspected Case of Metastasis of Lung Cancer: A Case Report

Surgical Resection of Undifferentiated Pleomorphic Sarcoma (UPS) With Jejunal Perforation, A Suspected Case of Metastasis of Lung Cancer: A Case Report

Surgical resection of undifferentiated pleomorphic sarcoma (UPS) with jejunal perforation, a suspected case of metastasis of lung cancer

Pediatric Undifferentiated Pleomorphic Sarcoma of the Cecum

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