G-protein β3 subunit (GNB3) gene polymorphisms and cardiovascular disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Renner, Wilfried; Hoffmann, Michael M.; Grünbacher, Gerda; Winkelmann, Bernhard R.; Boehm, Bernhard O.; März, Winfried

doi:10.1016/j.atherosclerosis.2006.07.001

Cited by 19 publications

(14 citation statements)

References 21 publications

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“…A total of six studies [23][24][25][26][27][28][29] were found. Of these, one [29] did not met our eligibility criteria (i.e.…”

Section: Characteristics Of the Participant Studiesmentioning

confidence: 99%

“…The G-350A promoter variant Four investigations encompassing 7,292 participants (2,738 hypertensives and 4,554 normotensives; 3,550 overweight and 3,742 lean) were available for the association of the G-350A promoter variant with both blood pressure-and adiposity-related phenotypes [23,26,28,30]. All controls groups were in Hardy-Weinberg equilibrium (Supplementary Tables S1-S2).…”

Section: Single-marker-based Meta-analysismentioning

confidence: 99%

“…Four studies had participants genotyped for both G-350A and C825T variants, enabling haplotypic analyses that encompassed 7,292 participants (2,738 hypertensives and DBP diastolic blood pressure, SBP systolic blood pressure, OR odds ratio, D expected linear increment in the trait per additional copy of the riskallele, s 2 estimated between-study variance, P(Q) P value for the Cochran's Q test 4,554 normotensives; 3,550 overweight and 3,742 lean) [23,26,28,30]. While a distinct pattern of LD among populations of different ancestries is observed, we found evidence for a significant LD and high to moderate D 0 scores between the G-350A variant and the C825T polymorphism (P \ 0.01 for all studies, Supplementary Table S7).…”

Section: G-350a-c825t Haplotypesmentioning

confidence: 99%

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Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

et al. 2014

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The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein b3 subunit (GNB3) gene with representative cardiovascular risk factors/phenotypes: hypertension, overweight, and variation in the systolic and diastolic blood pressures (SBP and DBP, respectively) and as well as body mass index (BMI). A comprehensive literature search was undertaken in Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar to identify potentially relevant articles published up to April 2011. Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for all studies. The three most investigated GNB3 polymorphisms (G-350A, C825T and C1429T) were considered. Expectation-maximization and generalized linear models were employed to estimate haplotypic effects from data with uncertain phase while adjusting for covariates. Study-specific results were combined through a random-effects multivariate meta-analysis. After carefully adjustments for relevant confounding factors, our analysis failed to support a role for GNB3 haplotypes in any of the investigated phenotypes. Sensitivity analyses excluding studies violating Hardy-Weinberg expectations, considering gender-specific effects or more extreme phenotypes (e.g. obesity only) as well as a fixedeffects ''pooled'' analysis also did not disclose a significant influence of GNB3 haplotypes on cardiovascular phenotypes. We conclude that the previous cumulative evidence does not support the proposal that haplotypes formed by common GNB3 polymorphisms might contribute either to Electronic supplementary material The online version of this article

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“…A total of six studies [23][24][25][26][27][28][29] were found. Of these, one [29] did not met our eligibility criteria (i.e.…”

Section: Characteristics Of the Participant Studiesmentioning

confidence: 99%

Section: Single-marker-based Meta-analysismentioning

confidence: 99%

Section: G-350a-c825t Haplotypesmentioning

confidence: 99%

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Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

et al. 2014

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“…This comparability of the allele frequencies indicates that the observed high cardiovascular risk in the HIPPOCRATES population is probably not related to marked differences in genetic make up of the investigated polymorphisms. 17,18,[24][25][26] Polymorphisms Angiotensinogen (M235T) polymorphism. The observed decreased risk for CVD for carriers of the rare T-allele of the AGT polymorphism needs further explanation.…”

Section: Allele Frequenciesmentioning

confidence: 99%

The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project

et al. 2009

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This study was designed to examine the contribution of six polymorphisms to the occurrence of cardiovascular disease (CVD) in a Dutch primary care population with a high prevalence of cardiovascular risk factors. In this cross-sectional case-control study, 232 patients with CVD and 571 event-free controls were studied. Patients were genotyped for the AGTR1 (A1166C), AGT (M235T), ACE (4656rpt), NOS3 (E298D), GNB3 (C825T) and ADD1 (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the relationship between genotypes and CVD. Receiver operating characteristic (ROC) analysis was used to quantify the contribution of the polymorphisms to the prediction of CVD. No differences in either genotype or allele frequencies were found between CVD cases and controls. Multivariate analyses, corrected for multiple testing according to Bonferroni, showed significant protective associations for the T-allele of AGT (OR ¼ 0.55 (0.34-0.84)) and for the T-allele of ADD1 (OR ¼ 0.52 (0.31-0.82)). ROC analysis showed only a very small improvement of CVD risk prediction by adding the six polymorphisms to a model with traditional risk factors. Our data suggest that a major attribution of the six polymorphisms to the cardiovascular risk prediction in a primary care population such as HIPPOCRATES is unlikely.

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“…3 The T allele has been associated with hypertension in Caucasian populations in a number of large, independent, case-control and cross-sectional studies (odds ratio 1.3-1.8), although with inconsistent results. 1,4 Recent data suggest that the T allele may be associated with specific phenotypes, such as lowrenin, 5 altered electrolyte homeostasis, 6 obesity, insulin resistance and the metabolic syndrome. 1 The aim of the study was to determine whether the GNB3 polymorphism predicts age of onset, hypertension severity, specific endocrine/biochemical profiles, arterial stiffness and the presence of microalbuminuria.…”

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confidence: 99%

Influence of the G-protein β-3 subunit gene C825 T polymorphism on the clinical phenotype of newly diagnosed essential hypertension

et al. 2007

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G-protein β3 subunit (GNB3) gene polymorphisms and cardiovascular disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Cited by 19 publications

References 21 publications

Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

The contribution of six polymorphisms to cardiovascular risk in a Dutch high-risk primary care population: the HIPPOCRATES project

Influence of the G-protein β-3 subunit gene C825 T polymorphism on the clinical phenotype of newly diagnosed essential hypertension

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