G protein β3 subunit variant and essential hypertension in Taiwan — a case–control study

Tsai, Cheng‐Ho; Yeh, Hung‐I; Chou, Yu-San; Liu, Hsin‐Fu; Yang, Tsuey Ching; Wang, Jyh-Chwan; Wang, Nancy M.; Chang, Jan‐Gowth

doi:10.1016/s0167-5273(00)00209-6

Cited by 21 publications

(20 citation statements)

References 18 publications

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“…This is consistent with the earlier finding in Korean adolescents. 31 This similar results have been reported for Japanese, 26 northern Han Chinese, 27,32 Taiwan Hans 33 and African Americans. 34 On the contrary, a number of studies of Caucasians have confirmed an association between the 825T allele and EH.…”

Section: Discussionsupporting

confidence: 69%

“…The frequency of the 825T allele in the present subjects was remarkably higher (50.1%) than that reported in Amerindians (26.5%) and western Europeans (29.6%), 32 but was similar to that described in Taiwan Han Chinese (54.3%), 29 northern Chinese (52%), 25 Canadian Oji-Cree (50.1%) 37 and Japanese populations (49%). 33 On the other hand, the frequency of the 825T allele in our population was much lower than that in Africans (79%), whereas it was slightly higher than the southern Chinese population (43.2%) reported by Siffert et al 37 As for the ACE I/D polymorphism, the D allele of the ACE gene is reportedly associated with the development of EH. 15 Many studies have examined possible associations between the ACE I/D poly- 18 By contrast, Zaman et al 13 and Matsubara et al 15 reported that there were no associations between the ACE I/D polymorphism and hypertension in males or females.…”

Section: Discussioncontrasting

confidence: 57%

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Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

et al. 2006

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Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein b3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P ¼ 0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (Po0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P ¼ 0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

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Section: Discussionsupporting

confidence: 69%

Section: Discussioncontrasting

confidence: 57%

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

et al. 2006

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“…Initially, the 825T allele was found to be associated with an increased risk of hypertension in a sample of approximately 850 subjects [1], and this observation was confirmed in independent studies of various sample sizes [5,17]. Although a similar tendency of increased T allele frequency among hypertensive patients was observed in two further additional studies, there was no statistically significant association of this allele with hypertension [8,9]. In addition, data from one study suggested the inverse association-increased C allele frequency among hypertensive patients-although this finding was not statistically significant [11].…”

Section: Introductionmentioning

confidence: 76%

“…Due to their pivotal function in many cell types, variation in the genes encoding the subunits of G proteins has the potential to play a role in numerous clinical conditions. Specifically, investigators have studied possible associations of the frequent substitution of a C with a T nucleotide at position 825 in exon 10 in the gene encoding the G protein β3 subunit (GNB3), resulting in the silent Ser275Ser polymorphism, with hypertension [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] and related cardiovascular phenotypes [16][17][18][19][20][21][22], and with obesity [22][23][24][25], psychological syndromes [26][27][28], type 1 diabetes complications (nephropathy, retinopathy and neuropathy) [29,30], type 2 diabetes [13,22,31,32], cancer [33] and various immunological responses [34]. The 825C>T polymorphism is associated with the occurrence of a splice variant with an in-frame deletion of 41 amino acids (from exon 9) including the fourth of seven Trp-Asp repeats, each consisting of approximately 40 highly conserved amino acids, which normally form a β-propeller peptide structure [1].…”

Section: Introductionmentioning

confidence: 99%

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

et al. 2005

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Aims/hypothesis: The 825C>T polymorphism in the gene encoding the G protein β3 subunit (GNB3) causes enhanced G protein activation and increased in vitro cell proliferation. This polymorphism is also repeatedly associated with an increased risk of hypertension and has been studied in relation to obesity with divergent results. Only a few association studies have investigated whether this polymorphism is related to type 2 diabetes or the metabolic syndrome. We estimated the impact of the GNB3 825C>T polymorphism in relatively large-scale association studies of common phenotypes of the metabolic syndrome. Materials and methods: The GNB3 825C>T polymorphism was genotyped in 7,518 white Danish subjects using mass spectrometry analysis of PCR products. Case-control studies were undertaken for obesity, hypertension, type 2 diabetes and the metabolic syndrome, and a meta-analysis including data from the present study and previous studies of hypertension was performed. Quantitative trait studies of metabolic variables were carried out in 4,387 glucose-tolerant subjects. Results: We observed minor differences in 825C>T genotype distributions for type 2 diabetes (CC/CT/TT 49/41/10% (control) vs 46/46/9% (cases), respectively, p=0.007); however, after correction for multiple testing, these were not statistically significant. No association was found with hypertension, obesity or the metabolic syndrome. Curiously, the T allele was associated with nominally lower systolic and diastolic blood pressure levels-a finding in contrast with most previous studies-but not with other metabolic variables. Meta-analysis demonstrated a high degree of heterogeneity between study populations of different ethnic origin. Although there was a tendency towards an increased risk of hypertension among 825T allele carriers, this was not statistically significant. Conclusions/interpretation: The present study suggests no major involvement of the GNB3 825C>T polymorphism in components of the metabolic syndrome.

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“…Subsequent report from some researchers in Europe 11,17 and Australia 12 had similar results. However, results of studies investigating the association between the GNB3 C825T polymorphism and hypertension in Japanese, 18 Tanwan Hans, 19 Canadian Oji-cree, 13 and African Americans 14 have proved conflicting. Our findings contrast with those of Siffert et al 10 but is consistent with other reports about this particular polymorphism.…”

Section: Discussionmentioning

confidence: 99%

GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate

Wang

Lin

et al. 2004

J Hum Hypertens

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The Kazakh inhabitants living in Barkol pasture of northeast China belong to a genetic isolate characterized by ethnically homogeneous and a communal pastoral lifestyle. To investigate whether the polymorphisms in the G-protein b-3 subunit (GNB3) gene and angiotensin-converting enzyme (ACE) gene are associated with essential hypertension (EH), we carried out a case-control study of 290 hypertensive subjects and 244 normotensive (NT) controls randomly selected from Kazakh populations of Barkol. A previous medical history of diabetes and hypertension, and body mass index (BMI) was recorded. Plasma glucose, triglyceride, and cholesterol were measured. The insertion/deletion (I/D) polymorphism of the ACE gene and the C825T polymorphism of the GNB3 gene were determined by the polymerase chain reaction (PCR) technique. The distributions of genotypes and alleles for the two polymorphisms did not differ significantly between the case and control populations, and odds ratio of EH related to the ACE gene D allele and GNB3 gene T allele was not significantly different from 1.0. Logistic regression analysis shows the variation at the GNB3 and ACE did not have any statistically significant synergistic effect on blood pressure (BP). Stratification of NT and untreated hypertensives according to I/D polymorphism of ACE gene and C825T polymorphism of GNB3 gene disclosed no significant difference across genotypes with respect to BMI, glucose, triglyceride, cholesterol, systolic and diastolic BP. In conclusion, the polymorphisms in the GNB3 gene and ACE gene, solely or combined, did not confer a significantly increased risk for the development of EH in the Kazakh isolate of northeast China.

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G protein β3 subunit variant and essential hypertension in Taiwan — a case–control study

Cited by 21 publications

References 18 publications

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes

GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate

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