Inorg. Chem. Front.
 2025
DOI: 10.1039/d4qi02098g
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G-quadruplex-guided bifunctional platinum complexes induce multiple pyroptosis pathways for antitumor therapy

Tian-Zhu Ma,
Liu-Yi Liu,
You-Liang Zeng
et al.

Abstract: G-quadruplexes (G4s), as a special nucleic acid secondary structure, is a promising therapeutic target for enhancing immune response. We designed a bifunctional (two Pt-Cl bond) PyPDSplatin complex (BiPP) by coupling...

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