G2-population cells in mouse kidney and duodenum and their behavior during the cell division cycle

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest

“…The G2 arrest we defined leads eventually to apoptosis (data not shown), so it is not likely to be a situation that would be tolerated in an intact organism unless the cues for apoptosis were overridden in certain cells or tissues. G2-arrested cells normally exist in many healthy mammalian tissues and are activated to enter mitosis promptly after a stimulus (Pederson and Gelfant, 1970). We of course cannot readily extrapolate the present finding with a cultured human cell line to how nucleolar stress might affect the cell cycle in an organism.…”

Tritiated Thymidine: A Breakthrough in DNA Replication and Repair

“…I first encountered tritiated thymidine when I was a lab technician working in a project on tissue regeneration. I injected mice every 6 hours all day and night long and then got the idea to just put it in their drinking water, which worked well (3). As I moved on in my career, tritiated thymidine became a distant mirror.…”

Radiosensitivity, RNA, and Protein Metabolism of "Leaky" and Arrested Cells in Sunflower Root Meristems (Helianthus annuus)

“…In dogfish erythroblasts, however, protein synthesis continued in the presence of AMD because of the presence of stable mRNA (Pederson and Gelfant, 1970a). Schneiderman, Dewey, and Highfield (1971) point out that, in Chinese hamster cells, Gi events requiring RNA and protein synthesis must occur before DNA synthesis.…”

“…The G2 populations in mouse ear epidermis was held up in G2 for prolonged times. The cells retained their capacity to divide and were stimulated to do so for compensatory growth, such as after wounding (Pederson and Gelfant, 1970b). Different cell population responses to light, in plant tissues, has been suggested to occur in Lemna thallus (Halaban, in press).…”