G6PD Deficiency

Muzrakchi, Ahmed Al; Gehani, A. A.

doi:10.5339/qmj.2004.1.19

Cited by 2 publications

(1 citation statement)

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“…Therefore, G6PD deficiency can be considered as a necessary cause of favism although it is a not sufficient cause. Moreover, the great majority of favism manifestations occurs in people with severely deficient variants of G6PD, while only in a few cases this disease has been observed in subjects with other G6PD variants [21]. Although convicine can cause the same problems in subjects affected by β-glucosidases deficiency, we decided to determinate only vicine content, considering that in Vicia faba L. convicine content is about half the vicine one [22,23].…”

Section: Discussionmentioning

confidence: 99%

From by-Product to Unconventional Vegetable: Preliminary Evaluation of Fresh Fava Hulls Highlights Richness in L-Dopa and Low Content of Anti-Nutritional Factor

Renna

Cillis

Leoni

et al. 2020

Foods

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Faba bean hulls are a by-product, generated from the processing of beans and usually disposed of as waste, utilized in some recipes of Italian traditional cuisine. In this research, a quality evaluation of faba hulls in six genotypes (four local varieties—‘Cegliese’, ‘Iambola’, ‘San Francesco’ and ‘FV5′—and two commercial ones—‘Aguadulce supersimonia’ and ‘Extra-early purple’) of faba bean (Vicia faba L. var. major Harz) for fresh consumption grown with two plant densities (4.16 and 2.08 plants m−2) was carried out. For all the measured parameters, the statistical analysis reveals that the interaction between plant density and genotype was not significant. On the other hand, independently of the genotype, the higher the plant’s density the higher was the pods’ yield per unit area, while the average percentage of hulls was of 75% with little differences between genotypes. All genotypes showed a low content of vicine (12.4 mg 100 g−1 FW), a well know favism-inducing factor, and a very high phenols content (between 443 and 646 mg 100 g−1 FW) and levo-dihydroxy phenylalanine (L-dopa—on average 170 mg 100 g−1 FW), used for the treatment of patients affected by Parkinson’s disease. In conclusion, this study highlights the good potential of faba hulls as unconventional vegetable, suggesting its use as a new functional food in the daily diet and also for patients with Parkinson’s disease.

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Section: Discussionmentioning

confidence: 99%

From by-Product to Unconventional Vegetable: Preliminary Evaluation of Fresh Fava Hulls Highlights Richness in L-Dopa and Low Content of Anti-Nutritional Factor

Renna

Cillis

Leoni

et al. 2020

Foods

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Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria

Martiniano,

Haber,

Almarri

et al. 2023

Preprint

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The harsh climate of Arabia has posed challenges in generating ancient DNA from the region, hindering the direct examination of ancient genomes for understanding the demographic processes that shaped Arabian populations. In this study, we report whole genome sequence data obtained from four Tylos-period individuals from Bahrain. Their genetic ancestry can be modelled as a mixture of sources from ancient Anatolia, Levant and Iran/Caucasus, with variation between individuals suggesting population heterogeneity in Bahrain before the onset of Islam. We identify the G6PD Mediterranean mutation associated with malaria-resistance in three out of four ancient Bahraini samples and estimate that it rose in frequency in Eastern Arabia from 5-6 kya onwards, around the time agriculture appeared in the region. Our study provides the first characterisation of the genetic composition of ancient Arabians, shedding light on the population history of Bahrain and demonstrating the feasibility of aDNA studies in the region.

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G6PD Deficiency

Abstract: G6PD deficiency is the most common enzyme deficiency disease worldwide, affecting 10% of the world's population. It is an X linked recessive disease therefore it affects males more than females (females are usually carriers of the disease).

Cited by 2 publications

References 0 publications

From by-Product to Unconventional Vegetable: Preliminary Evaluation of Fresh Fava Hulls Highlights Richness in L-Dopa and Low Content of Anti-Nutritional Factor

From by-Product to Unconventional Vegetable: Preliminary Evaluation of Fresh Fava Hulls Highlights Richness in L-Dopa and Low Content of Anti-Nutritional Factor

Ancient genomes illuminate Eastern Arabian population history and adaptation against malaria

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