GABA Tea Extract Inhibit the Colony Formation and Invasion of Colorectal Cancer Cells

Abstract

Objectives: The study is aim at evaluating the effects of GABA tea on colorectal cancer cell proliferation, colony formation and invasion. Methods: Colorectal cancer cell line HT-29 treated with GABA tea extract (12.5~200g/mL) were assessed for viability by MTT assay and for their invasion potential by evaluating their ability to penetrate through a matrix gel-coated Boyden chamber. Results: GABA tea extract exhibited slight effect on cell proliferation of HT-29. The colony formation was inhibited in both culture plate and Boyden chamber. Conclusions: GABA tea extract inhibited the colony formation and invasion of colorectal cancer cells. GABA tea is a potential adjuvant agent for colorectal cancer therapy.