GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

Chen, Junzi; Li, Zhongxia; Wang, Yi; Chen, Liying

doi:10.1007/s12264-024-01195-1

Neurosci. Bull.

2024

DOI: 10.1007/s12264-024-01195-1

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GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

Junzi Chen,

Zhongxia Li,

Yi Wang

et al.

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2024

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Cited by 2 publications

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Novel Mechanism, Drug Target and Therapy in Epilepsy

Xu,

Wang,

Chen

2024

Neurosci. Bull.

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Novel Mechanism, Drug Target and Therapy in Epilepsy

Xu,

Wang,

Chen

2024

Neurosci. Bull.

View full text Add to dashboard Cite

Anti-epileptic activity of casticin phytoconstituent from Vitex negundo on validated animal model

Kumar,

Bais

2024

J. Drug Delivery Ther.

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This study investigates the antiepileptic potential of the methanolic extract of Vitex negundo leaves in seizure models induced in mice using lithium-pilocarpine, maximal electroshock (MES), strychnine, picrotoxin, and pentylenetetrazol. The extract demonstrated a protective effect against seizures induced by MES and enhanced the efficacy of standard anticonvulsant drugs against chemically-induced seizures. The results suggest that the flavonoids present in the methanolic extract may exert their antiepileptic effects by modulating GABAergic pathways and blocking sodium (Na⁺) channels in a dose-dependent manner. These findings highlight the potential of Vitex negundo methanolic extract as a promising therapeutic candidate for epilepsy treatment. Keywords: Vitex negundo, methanolic extract, maximal electroshock (MES), antiepileptic, animal models, GABAergic pathway

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GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy

Cited by 2 publications

References 10 publications

Novel Mechanism, Drug Target and Therapy in Epilepsy

Novel Mechanism, Drug Target and Therapy in Epilepsy

Anti-epileptic activity of casticin phytoconstituent from Vitex negundo on validated animal model

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