Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

L’usage préventif de gabapentine diminue significativement la douleur postopératoire et les besoins d’analgésique de secours lors d’une cholécystectomie laparoscopique

“…13 It was also demonstrated that a 600 mg single dose of gabapentin enhanced the effect of morphine but side effects appeared in approximately 40% of volunteers when these drugs were used concomitantly. 13 Another study of 22 human volunteers who received 1200 mg of gabapentin or placebo in a double-blind, randomized cross-over fashion on two separate study days, demonstrated reduced primary mechanical allodynia in acute inflammation following a first degree thermal injury, suggesting that gabapentin had clinical potential in the treatment of postoperative pain. 14 The analgesic efficacy of gabapentin when it was used as a preemptive analgesic (one hour before the surgical stimulus) has been demonstrated in surgical patients by Dirks et al who found a substantial reduction in postoperative morphine consumption without significant side effects.…”

“…Both drugs, in earlier clinical trials, have been used as a preemptive analgesic and found to be safe and effective. [3][4][5]12,13 The preemptive administration of gabapentin and tramadol approximately two hours before surgery appears rational in order to attain maximal plasma concentrations at the time of surgical stimuli. It has also been demonstrated that a single dose of 600 mg of gabapentin added to 60 mg slow release morphine increases pain tolerance to the cold pressure test in humans.…”

“…12 Although gabapentin has been used in the treatment of neuropathic pain syndromes, it has also demonstrated potent antihyperalgesic proprieties in preclinical and clinical studies, without affecting acute nociception. 5,6,[12][13][14][15][16] In experimental studies gabapentin suppressed experimentally induced hyperalgesia and its intrathecal administration reduced tactile allodynia after incision. Gabapentin enhanced pain behaviour in rats after formalin-induced pain and reduced mechanical hyperalgesia in a rat model of postoperative pain.…”

“…Though the cold pressure test is a test of short duration and tolerance to pain and is not synonymous with analgesic efficacy, the available data are useful when planning the treatment of acute pain with gabapentin. 13 It was also demonstrated that a 600 mg single dose of gabapentin enhanced the effect of morphine but side effects appeared in approximately 40% of volunteers when these drugs were used concomitantly. 13 Another study of 22 human volunteers who received 1200 mg of gabapentin or placebo in a double-blind, randomized cross-over fashion on two separate study days, demonstrated reduced primary mechanical allodynia in acute inflammation following a first degree thermal injury, suggesting that Pandey et al: PREOPERATIVE GABAPENTIN 361 FIGURE 2 Mean dose of rescue analgesic fentanyl consumption in gabapentin, tramadol and placebo groups.…”

Neuropathic Pain Management in Chronic Laminitis

“…126 After IV administration plasma gabapentin concentrations remained above the 3-4 µg/mL range for approximately 15 hrs, similar to the dose associated with significant analgesic effects in adult human volunteers. 128 In the horse, oral bioavailability of gabapentin is relatively poor (~ 16 %) and therefore plasma gabapentin concentrations decreased much more rapidly than after IV drug administration (i.e. within 2-3 hrs) below the analgesic threshold.…”