Gabapentin for post-operative nausea and vomiting: a pilot study

Abstract

There are three major components of vomit reflex, the emetic detectors, integrative mechanism, and motor output. The main sensors of somatic stimuli are located in the gut and chemo-receptor trigger zone (CTZ). The emetic stimuli in gut are detected by two types of vagal afferent fibers. Mechanoreceptors They are located in the muscular wall of the gut and are activated by contraction and distension of the gut, on physical damage and manipulation during surgery.

Gabapentin for post‐operative pain management – a systematic review with meta‐analyses and trial sequential analyses

“…A total of 135 studies were included . One hundred and thirty‐two trials with 9498 patients were included for the evaluation of benefit and furthermore, three non‐randomized studies were included for the evaluation of harm.…”

“…Sixteen trials had overall low risk of bias . Seventy‐seven trials had high and 39 trials unclear risk of bias . Reasons for unclear and high risk of bias were mainly ‘selective outcome reporting’ or ‘other bias’ (Fig.…”

A systematic review and meta‐regression analysis of prophylactic gabapentin for postoperative pain

“…Figure and Table detail the 133 trials we included in the review, with our categorisation of risks of bias in Fig. . We excluded one duplicate trial , three trials that were unavailable as full text , five trials that did not use a placebo , one trial that used combination therapy and two uncontrolled trials .…”

Dose-related beneficial and harmful effects of gabapentin in postoperative pain management – post hoc analyses from a systematic review with meta-analyses and trial sequential analyses

“…Treatment with gabapentin included both single-dose (84 trials) 9 , 12 , 25 – 29 , 31 – 36 , 40 – 45 , 47 , 49 – 52 , 56 , 58 , 59 , 61 , 63 , 65 – 67 , 69 – 73 , 75 – 78 , 82 – 86 , 88 , 90 – 94 , 96 , 97 , 99 , 102 – 106 , 109 , 111 – 118 , 120 – 122 , 124 , 125 , 128 – 131 , 133 , 136 , 138 , 139 , 143 and multiple-dose administration (38 trials). 5 , 30 , 37 – 39 , 46 , 48 , 53 – 55 , 57 , 60 , 62 , 68 ,…”