GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47

LV, HUALIANG; LAI, CHANGCHUN; ZHAO, WENQU; SONG, YIBO

doi:10.32604/or.2022.025262

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…In lung carcinomas, differential expression of lncRNAs has been observed depending on the cancer type. Representative cases are SLC9A3-AS1, reported upregulated; LINC01554 and GABPB1 reported downregulated in NSCLC tissues [166][167][168], while RBPMS-AS1 expression was found to be diminished in lung adenocarcinoma [169]. Other studies have shown the reduced expression of LINC00294 in colorectal carcinoma tissues [170], while SLFNL1-AS1, KCNQ1OT1, NEAT1, XIST, AC016876.2, AC026362.1 were found to be downregulated in colon cancer cell lines [171].…”

Section: Discussionmentioning

confidence: 96%

miRNAs as Interconnectors between Obesity and Cancer

González-Sánchez,

Granados-López,

López-Hernández

et al. 2024

ncRNA

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Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss miRNAs and lncRNAs dysregulation involved in obesity and some cancers, shedding light on how these conditions may exacerbate one another through the dysregulation of ncRNAs. lncRNAs have been reported as regulating microRNAs. An in silico investigation of lncRNA and miRNA interplay is presented. Our investigation revealed 44 upregulated and 49 downregulated lncRNAs in obesity and cancer, respectively. miR-375, miR-494-3p, miR-1908, and miR-196 were found interacting with 1, 4, 4 and 4 lncRNAs, respectively, which are involved in PPARγ cell signaling regulation. Additionally, miR-130 was found to be downregulated in obesity and reported as modulating 5 lncRNAs controlling PPARγ cell signaling. Similarly, miR-128-3p and miR-143 were found to be downregulated in obesity and cancer, interacting with 5 and 4 lncRNAs, respectively, associated with MAPK cell signaling modulation. The delicate balance between miRNA and lncRNA expression emerges as a critical determinant in the development of obesity-associated cancers, presenting these molecules as promising biomarkers. However, additional and deeper studies are needed to reach solid conclusions about obesity and cancer connection by ncRNAs.

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Section: Discussionmentioning

confidence: 96%

miRNAs as Interconnectors between Obesity and Cancer

González-Sánchez,

Granados-López,

López-Hernández

et al. 2024

ncRNA

View full text Add to dashboard Cite

show abstract

“…GABPB1-AS1 is negatively associated with response and is a long non-coding RNA (lncRNA) that regulates GABPB1. Upregulation of GABPB1-AS1 can eventually suppress the cellular antioxidant capacity and has been found to serve as a potential biomarker in prostate cancer (56)(57)(58). ANKRD49 is positively associated with response, and is responsible for upregulating cell proliferation (59,60).…”

Section: Discussionmentioning

confidence: 99%

Cellular and transcriptional profiles of peripheral blood mononuclear cells pre-vaccination predict immune response to preventative MUC1 vaccine

Yuan,

McKeague,

Raghu

et al. 2024

Preprint

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A single arm trial (NCT007773097) and a double-blind, placebo controlled randomized trial (NCT02134925) were conducted in individuals with a history of advanced colonic adenoma to test the safety and immunogenicity of the MUC1 tumor antigen vaccine and its potential to prevent new adenomas. These were the first two trials of a non-viral cancer vaccine administered in the absence of cancer. The vaccine was safe and strongly immunogenic in 43% (NCT007773097) and 25% (NCT02134925) of participants. The lack of response in a significant number of participants suggested, for the first time, that even in a premalignant setting, the immune system may have already been exposed to some level of suppression previously reported only in cancer. Single-cell RNA-sequencing (scRNA-seq) on banked pre-vaccination peripheral blood mononuclear cells (PBMCs) from 16 immune responders and 16 non-responders identified specific cell types, genes, and pathways of a productive vaccine response. Responders had a significantly higher percentage of CD4+ naive T cells pre-vaccination, but a significantly lower percentage of CD8+ T effector memory (TEM) cells and CD16+ monocytes. Differential gene expression (DGE) and transcription factor inference analysis showed a higher level of expression of T cell activation genes, such as Fos and Jun, in CD4+ naive T cells, and pathway analysis showed enriched signaling activity in responders. Furthermore, Bayesian network analysis suggested that these genes were mechanistically connected to response. Our analyses identified several immune mechanisms and candidate biomarkers to be further validated as predictors of immune responses to a preventative cancer vaccine that could facilitate selection of individuals likely to benefit from a vaccine or be used to improve vaccine responses.

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“…Lung cancer is one of the most common malignant tumors globally, exhibiting the highest morbidity rate in recent years 31 , 61 . It encompasses two primary classifications: nonsmall-cell lung cancer (NSCLC), constituting ~85% of cases, and small-cell lung cancer (SCLC), accounting for ~15% of cases 62 , 63 . Lung adenocarcinoma (LUAD) is the most common histological variety among NSCLC subtypes, accounting for about 60% of cases 64 .…”

Section: Role Of Ska3 In Human Cancermentioning

confidence: 99%

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

Feng,

Wang,

Xiao

et al. 2024

International Journal of Surgery

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, we comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis and narrative summary. We also provided top 10 predicted drugs targeting SKA3. We proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients.

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GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47

Cited by 5 publications

References 28 publications

miRNAs as Interconnectors between Obesity and Cancer

miRNAs as Interconnectors between Obesity and Cancer

Cellular and transcriptional profiles of peripheral blood mononuclear cells pre-vaccination predict immune response to preventative MUC1 vaccine

SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

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