Gadolinium alginate nanogels for theranostic applications

Podgórna, Karolina; Szczepanowicz, Krzysztof; Piotrowski, Marek; Gajdošová, Markéta; Štěpánek, František; Warszyński, Piotr

doi:10.1016/j.colsurfb.2017.02.026

Cited by 44 publications

(21 citation statements)

References 31 publications

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“…The efficacy was characterized by the deterioration of the tumor [ 60 ]. In another study, Podgorna et al [ 61 ] prepared gadolinium (GdNG) containing nanogels for hydrophilic drug loading and to enable screening by MRI. The gadolinium alginate nanogels had an average diameter of 110 nm with stability duration of 60 days.…”

Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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“…Studies and research on toxicity tests conducted indicate the safety of the consumption of sodium alginate [32], agar [33], and glycerol [34].…”

Section: Introductionmentioning

confidence: 99%

Rethinking the Future of Food Packaging: Biobased Edible Films for Powdered Food and Drinks

2019

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In today’s society, packaging is essential. Without this, the materials would be messy and ineffective. Despite the importance and key role of packaging, they are considered to be useless, as consumers see it as a waste of resources and an environmental threat. Biopolymer-based edible packaging is one of the most promising solutions to these problems. Thus, inulin, biopolymers such as agar and sodium alginate, and glycerol were used to develop a single use edible material for food packaging. These biofilms were obtained and tested for three months. For inulin-based films, the results highlight improvements not only in physical properties (homogeneity, well-defined margins, light sweet taste, good optical properties, high solubility capacity or, as in the case of some samples, complete solubilization), but also superior mechanical properties (samples with high inulin content into composition had high tensile strength and extremely high elongation values). Even after three months of developing, the values of mechanical properties indicate a strong material. The optimization establishes the composition necessary to obtain a strong and completely water-soluble material. This type of packaging represents a successful alternative for the future of food packaging: they are completely edible, biodegradable, compostable, obtained from renewable resources, and produce zero waste, at low cost.

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“…Podgórna et al [90] reported the synthesis of gadolinium alginate gels nanoparticles (GdNG) with an average size of 110 nm by the reverse phase microemulsion and physical cross-linking method. First, by preparing a reverse-phase microemulsion, Rhodamine fluorescent dye was encapsulated, taking advantage of the super absorption of hydrogels networks.…”

Section: Functionalization By Non-covalent Interactionsmentioning

confidence: 99%

An Overview of Gadolinium-Based Oxide and Oxysulfide Particles: Synthesis, Properties, and Biomedical Applications

et al. 2021

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In the last decade, the publications presenting novel physical and chemical aspects of gadolinium-based oxide (Gd2O3) and oxysulfide (Gd2O2S) particles in the micro- or nano-scale have increased, mainly stimulated by the exciting applications of these materials in the biomedical field. Their optical properties, related to down and upconversion phenomena and the ability to functionalize their surface, make them attractive for developing new probes for selective targeting and emergent bioimaging techniques, either for biomolecule labeling or theranostics. Moreover, recent reports have shown interesting optical behavior of these systems influenced by the synthesis methods, dopant amount and type, particle shape and size, and surface functionality. Hence, this review presents a compilation of the latest works focused on evaluating the optical properties of Gd2O3 and Gd2O2S particles as a function of their physicochemical and morphological properties; and also on their novel applications as MRI contrast agents and drug delivery nanovehicles, discussed along with their administration routes, biodistribution, cytotoxicity, and clearance mechanisms. Perspectives for this field are also identified and discussed.

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Gadolinium alginate nanogels for theranostic applications

Cited by 44 publications

References 31 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

Rethinking the Future of Food Packaging: Biobased Edible Films for Powdered Food and Drinks

An Overview of Gadolinium-Based Oxide and Oxysulfide Particles: Synthesis, Properties, and Biomedical Applications

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