Gadolinium contrast agents- challenges and opportunities of a multidisciplinary approach: Literature review

Iyad, Nebal; S.Ahmad, Muntaser; Alkhatib, Sanaa G.; Hjouj, Mohammad

doi:10.1016/j.ejro.2023.100503

Cited by 57 publications

(19 citation statements)

References 75 publications

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“…Where T (1⁄2 b) is the biological half-life for 131 I in the human body which equals to 6.3 day as the previous study shows [26][27][28][29][30][31][32][33]., and T1/2p is the physical half-life for 131 I which is 8.04 day. Table 2 displays the correlation coefficient R between the dependent variable (Activity) and the independent variable (beta at 1m), which is equal to (0.723), as well as the square of the correlation coefficient (R square), which is (0.523), which shows the percentage of variation between the two coefficients (moderate dependently), and the ANOVA table, which displays the value of (0.00), indicating a strong relationship between the variable's Activity and beta.…”

Section: Resultsmentioning

confidence: 99%

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Ahmad,

Mohammad

2024

J. Phys.: Conf. Ser.

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Radioiodine-131 (I-131) treats hyperthyroidism and differentiated thyroid carcinoma. In I-131, beta radiation (β−) is utilized for treatment and gamma radiation (γ) is used for diagnostic. This research sought to determine if a patient would be treated by establishing an equation for beta-thyroid cell interaction. The prospective study included 35 thyroid cancer patients receiving I-131 treatment. Beta and gamma readings were taken at different distances and sent to the statistical shop to find the coefficients of change on which the beta reaction depends and the equation that depends on it to find the beta range involved in healing. The strongest equation was R square (98.1%). To measure beta at 1 m, use the equation with a 99% association between variables and independent variables, and improve with ANOVA with a p-value of 0.00 0.05. The equation is: β_1m= -123.893+(0.947*δ) +(0.123*ε) -(0.002*π) -(2.11*Log Gamma). The discrepancy between true beta readings (mean = 1040) and the equation (mean = 1087, p-value = 0.411) is more than 0.05. That indicates the values are same. The equation that measures beta during iodine therapy has been achieved, which is the first step to improved thyroid cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Ahmad,

Mohammad

2024

J. Phys.: Conf. Ser.

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“…MRI contrast agents are typically used to enhance the contrast of certain tissues or blood vessels . However, small molecular contrast agents have a short half-life in the body, lasting only a few minutes, which makes them unsuitable for long-term, repetitive imaging . Although contrast agents based on polymers or nanoparticles have longer circulation times in the body, they tend to accumulate in organs such as the liver and kidneys after long-term circulation, leading to particularly high MRI signals in these organs.…”

Section: Molecular Imagingmentioning

confidence: 99%

Recent Advances in Stimuli-Responsive Self-Immolative Polymers for Drug Delivery and Molecular Imaging

Li,

Liu,

et al. 2024

Chem. Mater.

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Stimuli-responsive self-immolative polymers (SIPs) represent a unique class of polymers that can undergo controlled, sequential head-to-tail depolymerization upon specific stimuli. Since their inception, they have evolved over two decades to become one of the most attractive polymer types. With their characteristic feature of "one stimulus, multiple responses", SIPs inherently possess the ability to serve as chemical amplifiers, which can amplify weak chemical or biological signals. This feature promises higher stimulus sensitivity, greater selectivity for specific microenvironments, and the potential to generate more persistent, extensive, and significant responses while consuming fewer stimuli sources. This Review summarizes the latest research advancements in stimuli-responsive SIPs for drug delivery and molecular imaging over the past five years. Regarding the structure of SIPs, we briefly overview the updates in self-immolation units, end-cap moieties, and sequence of SIPs. In terms of applications, we focus on the possible biological applications of SIPs in drug delivery for disease treatment and potential imaging methods. Finally, we provide a brief perspective of potential future directions for SIPs in these applications.

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“…Therefore, it is crucial to design contrast agents that have stronger contrast and minimal side effects. [97][98][99] Recently, biological nanomaterials have contributed to the development of medical imaging technology. Nanomolecular contrast agents exhibit excellent magnetization, longer cycle times, and fewer toxic side effects and have become a hot research topic today.…”

Section: Wide Application Of Ultrahigh Field Cmrmentioning

confidence: 99%

Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

Wang,

2023

Small Methods

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Acute myocardial infarction (AMI) is one of the primary causes of death worldwide, with a high incidence and mortality rate. Assessment of the infarcted and surviving myocardium, along with microvascular obstruction, is crucial for risk stratification, treatment, and prognosis in patients with AMI. Nonionizing radiation, excellent soft tissue contrast resolution, a large field of view, and multiplane imaging make cardiac magnetic resonance (CMR) a “one‐stop” method for assessing cardiac structure, function, perfusion, and metabolism. Hence, this imaging technology is considered the “gold standard” for evaluating myocardial function and viability in AMI. This review critically compares the advantages and disadvantages of CMR with other cardiac imaging technologies, and relates the imaging findings to the underlying pathophysiological processes in AMI. A more thorough understanding of CMR technology will clarify their advanced clinical diagnosis and prognostic assessment applications, and assess the future approaches and challenges of CMR in the setting of AMI.

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Gadolinium contrast agents- challenges and opportunities of a multidisciplinary approach: Literature review

Cited by 57 publications

References 75 publications

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Statistical calculation of beta radiotherapy dose using I-131: analysis and simulation method.

Recent Advances in Stimuli-Responsive Self-Immolative Polymers for Drug Delivery and Molecular Imaging

Recent Advances in Cardiac Magnetic Resonance for Imaging of Acute Myocardial Infarction

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