Gadoxetic acid-enhanced MRI compared with CT during angiography in the diagnosis of hepatocellular carcinoma

Surveillance and Diagnostic Algorithm for Hepatocellular Carcinoma Proposed by the Liver Cancer Study Group of Japan: 2014 Update

“…It has actually become common to encounter cases where hypervascular HCC or nodule-in-nodule HCC that is undetectable by MDCT is detected in a routine screening by EOB-MRI because of early enhancement in the arterial phase or clear hypointensity in the hepatobiliary phase [11,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103]. Furthermore, studies comparing the diagnostic performance of EOB-MRI and MDCT for hypervascular HCC have shown that EOB-MRI is superior or, at the very l...…”

Magnetic Resonance Imaging with Gadoxetic Acid Disodium for the Detection of Hepatocellular Carcinoma

“…Although a large number of studies have reported the superior value of DCE-MRI with the use of gadoxetic acid disodium for assessment of HCC (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), the sample size in these studies was relatively small and the findings have been incongruent. A meta-analysis (27) on MRI with gadoxetic acid disodium for HCC was published in 2013, and eight studies (8,12,16,18,19,22,24,25) contributed to present analysis, which had not been included in their metaanalysis.…”

“…A meta-analysis (27) on MRI with gadoxetic acid disodium for HCC was published in 2013, and eight studies (8,12,16,18,19,22,24,25) contributed to present analysis, which had not been included in their metaanalysis. The aim of the present study was to systematically review sufficient data on MRI with gadoxetic acid disodium for HCC.…”

Diagnosing Borderline Hepatic Nodules in Hepatocarcinogenesis: Imaging Performance

“…It is still challenging, however, to accurately characterize borderline hepatocellular nodules, including low-grade dysplastic nodules, high-grade dysplastic nodules, and early HCC, at imaging, because they usually have similar imaging features [10,14]. Several studies [15][16][17][18][19] have shown that conventional CT and MRI have limited sensitivity for the detection of early HCC and high-grade dysplastic nodules but that MRI with hepatobiliary contrast media has promise for this purpose. This article discusses the pathologic and radiologic features of these small nodular lesions and offers insight into the multistep process of hepatocarcinogenesis by describing the progression of imaging changes that link dysplastic nodules and early HCC to small HCC that has progressed.…”