Gaining insight into the neural basis of resting-state fMRI signal

Connecting the dots between cell populations, whole-brain activity, and behavior

“…To examine the relationship between neuronal spiking activity (measured by GCaMP) and BOLD signaling during the resting state, Ma et al. 126 utilized concurrent -based fiber photometry and rs-fMRI in rodents. They showed robust couplings between and BOLD activity in areas of the default mode network, such as dorsal hippocampus, providing further support for the role of neuronal spiking in the rs-fMRI BOLD signal.…”

“…They showed robust couplings between and BOLD activity in areas of the default mode network, such as dorsal hippocampus, providing further support for the role of neuronal spiking in the rs-fMRI BOLD signal. 126 Importantly, using signaling as the ground truth, they also showed that common data preprocessing techniques differentially impact functional connectivity mapping 126 [ Fig. 4(e) ].…”

“…Revised from Refs. 92 ; 87 ; 126 . Representative results from concurrent calcium and resting-state fMRI studies in (a)–(d) anesthetized and (e) awake rodents.…”

Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest

“…Cross-modal integration of BOLD fMRI with simultaneously measured optical fiber-based calcium recordings now opens the possibility of identifying the brain-wide measured hemodynamic BOLD response of the local optically measured SoI of a reference volume. The cross-modal approach is possible because the detection of the calcium transients is not disturbed by the strong magnetic field of the MR system, 10 – 18 while the implanted optical fiber does not cause signal artifacts due to field distortions in the fMRI measurements.…”

“…Ma et al. 16 found strong evidence that the neural mechanism for resting-state BOLD fMRI depends on the spiking activity of neurons using a cross-modal approach. Zhang et al.…”