Galactose-based polymer-containing phenylboronic acid as carriers for insulin delivery

Zhong, Yi; Song, Bo; He, Dan; Xia, Zemei; Wang, Peng; Wu, Junzi

doi:10.1088/1361-6528/ab9e26

Cited by 18 publications

(17 citation statements)

References 40 publications

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“…Notably, the color demonstrates a conspicuous transition at around 7 × 10 −3 m , corresponding to the diagnosis indicator of diabetes. [ 14 ] Namely, when the solution containing PNCs displays red, [glucose] is above this point, representing the possibility of illness. In contrast, when it turns yellow or green, [glucose] is in the normal fasting blood glucose concentration.…”

Section: Resultsmentioning

confidence: 99%

“…[ 13 ] The peaks at 1437 and 1313 cm –1 are assigned to the stretching vibration peaks of the benzene ring skeleton and the B—O bond of AAPBA. [ 14 ] The absorption peak at 583 cm –1 is ascribed to Fe‐O in Fe 3 O 4 . [ 15 ] From Figure 1g , the percentage of Fe 3 O 4 and organic substances (PVP and poly(AAPBA‐ co ‐HEAAm)) can be calculated to be 59.6 and 40.4 w%, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Glucose‐Sensing Photonic Nanochain Probes with Color Change in Seconds

et al. 2022

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Glucose‐sensing photonic crystals are promising for the significant advance of continuous glucose monitoring systems due to the naked‐eye colorimetric readouts and noninvasive detection of diabetes, but the long response time hampers their practical applications. Here, for the first time probes of photonic nanochains (PNCs) are demonstrated that are capable of continuously and reversibly sensing glucose concentration ([glucose]) variation within seconds by color change without power consumption, much faster by 2–3 orders of magnitude than previous ones. They are comprised of 1D equidistant arrays of magnetic nanoparticles enveloped by tens‐of‐nanometer‐thick phenylboronic acid‐functionalized hydrogels, and fabricated by developing selective concentration polymerization of monomers in binary microheterogeneous solvents of dimethyl sulfoxide (DMSO) and H2O. In this process, both 3‐acrylamido phenylboronic acid (AAPBA) and N‐2‐hydroxyethyl acrylamide (HEAAm) are preferentially dissolved in the small volume of free DMSO concentrated in the vicinity of poly vinylpyrrolidone coated Fe3O4 colloidal nanoparticles (Fe3O4@PVP), yielding Fe3O4@PVP@poly(AAPBA‐co‐HEAAm) PNCs after UV irradiation under magnetic field. The PNCs in phosphate buffered solution have a wavelength‐shift range up to 130 nm when [glucose] changes from 0 to 20 × 10−3 m. The results can facilitate real‐time glucose monitoring and provide an alternative to produce functional organic–inorganic nanostructures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Glucose‐Sensing Photonic Nanochain Probes with Color Change in Seconds

et al. 2022

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“…At high glucose levels, insulin release is also increased. Moreover, nanoparticles have shown low toxicity in cell and animal studies, and can effectively reduce blood glucose levels in mice for >96 h. Zhong et al, 14 also successfully synthesized the galactosyl block copolymer 6-O-sulfuric acid sebacic acid-D-galactopyran ester tert-butyl 3-acrylamide-phenylboronic acid (p(OVNG-b-AAPBA)). After encapsulating the nanoparticles with insulin, the increased AAPBA in the polymer, the drug loading, and high encapsulation efficiency can effectively maintain the 96-h blood glucose level of diabetic mice.…”

Section: Glycolipid-combined Pba-containing Biomaterialsmentioning

confidence: 99%

“…Moreover, it is a common glucose-sensitive material because of its costefficiency and easy fabrication. [11][12][13][14] This review focuses on the development process, performance, resolve resolution, and application of the glucose-sensitive polymer drug carrier of PBA and its derivatives, and also presents the prospective development direction and application in the field.…”

Section: Introductionmentioning

confidence: 99%

Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy

Ma¹,

Xiao-min²,

Shi³

et al. 2021

IJN

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The glucose-sensitive self-adjusting drug delivery system simulates the physiological model of the human pancreas-secreting insulin and then precisely regulates the release of hypoglycemic drugs and controls the blood sugar. Thus, it has good application prospects in the treatment of diabetes. Presently, there are three glucose-sensitive drug systems: phenylboronic acid (PBA) and its derivatives, concanavalin A (Con A), and glucose oxidase (GOD). Among these, the glucose-sensitive polymer carrier based on PBA has the advantages of better stability, long-term storage, and reversible glucose response, and the loading of insulin in it can achieve the controlled release of drugs in the human environment. Therefore, it has become a research hotspot in recent years and has been developed very rapidly. In order to further carry out a follow-up study, we focused on the development process, performance, and application of PBA and its derivatives-based glucose-sensitive polymer drug carriers, and the prospects for the development of this field.

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“…Phenylboronic acid (PBA) has always been a research hotspot as a potential mechanism for controlling blood sugar stability [ 5 , 6 ]. The phenylboronic acid group can be reversibly combined with sugar compounds containing cis-diol chains [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications

Xiao-min

Shi

et al. 2021

J Nanobiotechnol

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Background Diabetes complications are the leading cause of mortality in diabetic patients. The common complications are decline in antioxidant capacity and the onset of micro-inflammation syndrome. At present, glucose-responsive nanoparticles are widely used, as they can release insulin-loaded ultrafine particles intelligently and effectively reduce blood sugar. However, the toxicology of this method has not been fully elucidated. The plant extracts of pterostilbene (PTE) have a wide range of biological applications, such as antioxidation and inflammatory response improvement. Therefore, we have proposed new ideas for the cross application of plant extracts and biomaterials, especially as part of a hypoglycaemic nano-drug delivery system. Results Based on the PTE, we successfully synthesised poly(3-acrylamidophenyl boric acid-b-pterostilbene) (p[AAPBA-b-PTE]) nanoparticles (NPs). The NPs were round in shape and ranged between 150 and 250 nm in size. The NPs possessed good pH and glucose sensitivity. The entrapment efficiency (EE) of insulin-loaded NPs was approximately 56%, and the drug loading (LC) capacity was approximately 13%. The highest release of insulin was 70%, and the highest release of PTE was 85%. Meanwhile, the insulin could undergo self-regulation according to changes in the glucose concentration, thus achieving an effective, sustained release. Both in vivo and in vitro experiments showed that the NPs were safe and nontoxic. Under normal physiological conditions, NPs were completely degraded within 40 days. Fourteen days after mice were injected with p(AAPBA-b-PTE) NPs, there were no obvious abnormalities in the heart, liver, spleen, lung, or kidney. Moreover, NPs effectively reduced blood glucose, improved antioxidant capacity and reversed micro-inflammation in mice. Conclusions p(AAPBA-b-PTE) NPs were successfully prepared using PTE as raw material and effectively reduced blood glucose, improved antioxidant capacity and reduced the inflammatory response. This novel preparation can enable new combinations of plant extracts and biomaterials to adiministered through NPs or other dosage forms in order to regulate and treat diseases. Graphic abstract

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Galactose-based polymer-containing phenylboronic acid as carriers for insulin delivery

Cited by 18 publications

References 40 publications

Glucose‐Sensing Photonic Nanochain Probes with Color Change in Seconds

Glucose‐Sensing Photonic Nanochain Probes with Color Change in Seconds

Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy

Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications

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