Galactose toxicity in the rat as a model for premature ovarian failure: an experimental approach readdressed

Bandyopadhyay, Subhajit; Chakrabarti, Jana; Banerjee, Sutapa; Pal, Alok K.; Goswami, S.K.; Chakravarty, Baidyanath; Kabir, Syed N.

doi:10.1093/humrep/deg414

Cited by 69 publications

(99 citation statements)

References 33 publications

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“…For instance, in fertility clinic populations (11), the timing of dietary assessment may have been several months or years after the diagnosis of infertility, whereas for most women in this cohort, diet was assessed soon after conception attempts began and before the diagnosis of infertility. Our study agrees with most (10, 11) but not all (8) previous studies in providing support against the hypothesis of ovarian toxicity via galactose-lactose pathways (2)(3)(4).…”

Section: Discussionsupporting

confidence: 92%

“…3 Adjusted for total energy intake. 4 Adjusted for total energy intake, age, BMI, smoking history, parity, alcohol intake, physical activity, last method of contraception, and regular multivitamin use. PRESTO models were additionally adjusted for race/ethnicity and education.…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases the risk of ovarian toxicity (2)(3)(4). Moreover, women with galactosemia, a hereditary disease that affects galactose metabolism, are at increased risk of premature ovarian failure (5-7).…”

Section: Introductionmentioning

confidence: 99%

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Dairy intake and fecundability in 2 preconception cohort studies

Wise

Wesselink

Mikkelsen

et al. 2017

The American Journal of Clinical Nutrition

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Background: Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, and they have had conflicting findings. Objective: We prospectively evaluated dairy intake in relation to fecundability among women who were planning for pregnancy. Design: Data were derived from preconception cohort studies in Denmark (Snart Foraeldre) and North America [PRESTO (Pregnancy Study Online)] in which women completed a validated food-frequency questionnaire 10 d after enrollment. The dietary intake of dairy foods and their constituents was calculated based on reported frequencies, mean serving sizes, and standard recipes for mixed foods. Outcome data were updated every 8 wk for 12 mo or until reported conception. Analyses were restricted to 2426 women attempting pregnancy for #6 cycles at study entry. Fecundability ratios (FRs) and 95% CIs were estimated with the use of proportional probabilities regression models adjusted for potential confounders. Results: FRs for total dairy intake ($18 compared with ,7 servings/wk) were 1.37 (95% CI: 1.05, 1.78) among 1126 Snart Foraeldre participants and 1.04 (95% CI: 0.78, 1.38) among 1300 PRESTO participants (pooled FR: 1.11; 95% CI: 0.94, 1.31). The elevated FR for total dairy intake among Snart Foraeldre participants was limited to milk consumption and found only among women aged ,30 y. There was no clear association between low-or high-fat dairy intake and fecundability in either cohort. Although there was little evidence of an association between dietary intake of calcium, potassium, magnesium, or vitamin D and fecundability, a greater consumption of phosphorus and lactose was associated with slightly higher fecundability in both cohorts. Conclusions: Associations between dairy intake and fecundability were generally small and inconsistent across cohorts. Our findings do not support the hypotheses that a greater consumption of high-fat dairy improves fertility or that a greater consumption of lactose or low-fat dairy harms fertility.Am J Clin Nutr 2017;105:100-10.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Dairy intake and fecundability in 2 preconception cohort studies

Wise

Wesselink

Mikkelsen

et al. 2017

The American Journal of Clinical Nutrition

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“…An animal study found significantly lower concentrations of estradiol and elevated FSH and LH concentrations in rats fed high amounts of galactose, a breakdown component of lactose, compared with controls (14). In addition, progesterone concentrations were significantly decreased in rats after lactose treatment, whereas no differences were found in serum concentrations of estradiol (13).…”

Section: Discussionmentioning

confidence: 97%

“…The biological mechanisms that support an association between dairy food intake and ovulatory function are largely unknown. However, impaired ovarian function was observed in rats fed excessive amounts of lactose (13) and galactose (14), which points to potential biological pathways. These results highlight the need for further study of dairy food intake and reproductive function, particularly among healthy women.…”

Section: Introductionmentioning

confidence: 99%

Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women

Kim¹,

Wactawski‐Wende

Michels³

et al. 2017

The Journal of Nutrition

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Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

Coelho

Bierau

Lindhout

et al. 2017

The Anatomical Record

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Classic galactosemia results from deficient activity of galactose-1-phosphate uridylyltransferase (GALT), a key enzyme of galactose metabolism. Despite early diagnosis and early postnatal therapeutic intervention, patients still develop neurologic and fertility impairments. Prenatal developmental toxicity has been hypothesized as a determinant factor of disease. In order to shed light on the importance of prenatal GALT activity, several studies have examined GALT activity throughout development. GALT was shown to increase with gestational age in 7-28 weeks human fetuses; later stages were not investigated. Prenatal studies in animals focused exclusively on brain and hepatic GALT activity. In this study, we aim to examine GALT specific activity in late prenatal and adult stages, using a sheep model. Galactosemia acute target-organs-liver, small intestine and kidney-had the highest late prenatal activity, whereas the chronic target-organs-brain and ovary-did not exhibit a noticeable pre- or postnatal different activity compared with nontarget organs. This is the first study on GALT specific activity in the late prenatal stage for a wide variety of organs. Our findings suggest that GALT activity cannot be the sole pathogenic factor accounting for galactosemia long-term complications, and that some organs/cells might have a greater susceptibility to galactose toxicity. Anat Rec, 300:1570-1575, 2017. © 2017 Wiley Periodicals, Inc.

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Galactose toxicity in the rat as a model for premature ovarian failure: an experimental approach readdressed

Abstract: Experimental galactose toxicity may serve as a model for exploring some of the basic tenets of POF.

Cited by 69 publications

References 33 publications

Dairy intake and fecundability in 2 preconception cohort studies

Dairy intake and fecundability in 2 preconception cohort studies

Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women

Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

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