Galantamine hydrobromide: An agent for Alzheimer’s disease

Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats

“…Although the use of AChE-Is (e.g. donezepil, rivastigmine and galantamine), a symptomatic pharmacological treatment of AD, has been shown as beneficial to cognitive, functional and behavioral symptoms of the disease, it also causes undesired side effects (Sweeney et al, 1989;Bickel et al, 1991;Woodruff-Pak et al, 2001;Zarotsky et al, 2003;Liston et al, 2004). The most common adverse effects, related to cholinergic stimulation in the brain and peripheral tissues, include gastrointestinal, cardiorespiratory, extrapyramidal, genitourinary, and musculoskeletal symptoms, as well as sleep disturbances (Thompson et al, 2004).…”

Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies

“…However, only tacrine, donepezil, rivastigmine, and galanthamine have been approved by the Food and Drug Administration in the United States (Zarotsky et al, 2003). Until now, no drug of choice * Corresponding author.…”

Structure-based drug discovery of ApoE4 inhibitors from the plant compounds

“…1). A dataset of 11 active compounds used as references molecules were collected from Tocris bioscience (http://www.tocris.com/viewAllTargets.php#) and five other publications published in different journals Harvey, 2006, 2009;Mei et al, 2009;Zarotsky et al, 2003;Farlow et al, 1992) (Fig. 2).…”