2010
DOI: 10.1084/jem.20090121
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Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

Abstract: Recent studies have shown that a carbohydrate-binding protein, galectin-3, is a novel pro-angiogenic molecule. The mechanism by which galectin-3 promotes angiogenesis remains unknown. We demonstrate here that galectin-3 is a mediator of vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-mediated angiogenic response. Angiogenesis assays revealed that galectin-3 inhibitors, β-lactose and dominant-negative galectin-3, reduce VEGF- and bFGF-mediated angiogenesis in vitro and that … Show more

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Cited by 278 publications
(258 citation statements)
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“…In addition, galectin-3 is a mediator of the vascular endothelial growth factor-mediated angiogenic response and basic fibroblast growth factor-mediated angiogenic response. Angiogenesis assays revealed that galectin-3 inhibitors and knockout reduce vascular endothelial growth factor-mediated angiogenesis and basic fibroblast growth factor-mediated angiogenesis in vitro [77]. Therefore, treatment studies targeting galectin-3 require greater understanding of the role of this protein in both inflammation and angiogenesis.…”
Section: Galectin-3mentioning
confidence: 99%
“…In addition, galectin-3 is a mediator of the vascular endothelial growth factor-mediated angiogenic response and basic fibroblast growth factor-mediated angiogenic response. Angiogenesis assays revealed that galectin-3 inhibitors and knockout reduce vascular endothelial growth factor-mediated angiogenesis and basic fibroblast growth factor-mediated angiogenesis in vitro [77]. Therefore, treatment studies targeting galectin-3 require greater understanding of the role of this protein in both inflammation and angiogenesis.…”
Section: Galectin-3mentioning
confidence: 99%
“…It appears that Galectin-3 has proangiogenic activity via interactions with several endothelial cell surface receptors. For example, Galectin-3 interacts with αvβ3 integrin on endothelial cells and induces promotion of VEGF-and bFGF-mediated endothelial migration and, consequently, vessel branch formation (89).…”
Section: Protumourigenic Role Of Galectin3mentioning
confidence: 99%
“…In this context galectin-3 binding to 1-integrins leads to an internalisation signal, regulating receptor amount on the cell surface and thereby influencing cell signalling aspects (Furtak et al, 2001). Other integrins such as v 3 integrin on endothelial cells or the M subunit on macrophages are also bound by galectin-3 (Dong & Hughes, 1997;Markowska et al, 2010). Galectin-8 is known to have a major function in integrin-binding and integrin-mediated signalling (Zick et al, 2004).…”
Section: Cell-surface Glycoproteins As Binding Partners Of Galectinsmentioning
confidence: 99%
“…Galectin-3 increases for example angiogenesis by forming integrin v 3 lattices on the cell-surface leading to FAK regulated downstream signalling. Galectin-3 mediated angiogenesis depends on the growth factors VEGF and bFGF (Markowska et al, 2010). Another interesting function of galectin-3 is the chemotattraction of monocytes via a G-protein coupled receptor pathway and the role in eosinophil rolling to sites of inflammation (Rao et al, 2007;Sano et al, 2000).…”
Section: Selected Examples Of Cell Adhesion and Motility Regulated Bymentioning
confidence: 99%
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