Galectin 3 Level in Patients with Acute Coronary Syndrome and its Relation to Severity of Coronary Artery Disease

Soltan, Ghada Mahmoud; Samy, Niveen; Mashal, Aly

doi:10.4236/wjcd.2020.1012075

Cited by 5 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous reports demonstrated that Gal-3 concentrations had significant positive association with CAD severity evaluated by SYNTAX score in cases with CAD (17) , NSTEMI (16&26) , and STEMI (28) . Similarly, previous studies showed that Gensini score as a measure of CAD severity, had significant positive association with Gal-3 values among those with CAD (16,18,23&24) , NSTEMI (19) , and ACS (25) . Some studies showed that Gal-3 showed significant positive association with the number of stenotic vessels (12,15,16,18,20,21,23,25&27) and the number of coronary stenotic segments (21) , whereas other studies showed, Gal-3 concentrations did not differ with number of stenotic coronary arteries (30&37) .…”

Section: Discussionsupporting

confidence: 70%

“…The current study results may propose that Gal-3 as a major inflammatory marker, can have a substantial role in the pathogenetic process of plaque disturbance and ACS. Compared to patients with normal CA, earlier studies reported significantly high Gal-3 concentrations among CAD cases (11,(15)(16)(17)(18)(19)(20)(21)(22) , CCS (17,23&24) , ACS (25) , NSTEMI (16,17&26) , STEMI (17,27&28) , and premature myocardial infarction (29) . On the other hand, compared to patients with CCS, earlier studies demonstrated that Gal-3 values were significantly greater among those with ACS (16,24,30&31) and STEMI (17) .…”

Section: Discussionmentioning

confidence: 94%

“…In those with NSTEMI, Quisi et al, (26) reported that Gal-3 concentrations had significant negative association with EF. In contrast, a non-significant association was found between Gal-3 values and EF among patients with ACS (25) and STEMI (32&36) .…”

Section: Discussionmentioning

confidence: 98%

“…George et al, (31) showed a cut-off level of 11.02 ng/mL for Gal-3 to predict ACS. Soltan et al, (25) found that a Gal-3 cut-off value of ≥ 12.5 ng/mL was a predictor of ACS with sensitivity and specificity of 88.9% and 70%, respectively. Using a univariate logistic regression model, our study revealed that Gal-3 significantly predicted CAD.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Osman,

Algamal,

Elshal

et al. 2024

Ain Shams Medical Journal

View full text Add to dashboard Cite

Background: Galectin 3 (Gal-3) has great impact on initiation and progression of atherosclerosis as a cardiovascular inflammatory marker. The role of Gal-3 in coronary artery disease (CAD) remains a subject of debate. CAD and atherosclerosis are an inflammatory process. Aim of the work: to evaluate Gal-3 concentrations among patients with CAD presented with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS).Patients and Methods: 252 individuals were divided into control group with normal coronary angiography and patient group with obstructive CAD which was further subdivided according to the clinical presentations into ACS and CCS subgroups. All groups were matched for age and sex.Results: significantly higher Gal-3 values were found in CAD group, ACS subgroup, and CCS subgroup versus control group. Gal-3 values were significantly higher in ACS subgroup compared with CCS subgroup. Gal-3 concentrations demonstrated a non-significant association with age and EF. Gal-3 levels showed significant positive relationship with Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score in CAD group, CCS subgroup, and ACS subgroup. Gal-3 concentrations demonstrated significant positive relationship with the number of stenotic coronary arteries and segments in CAD group and CCS subgroup but not in ACS subgroup. Gal-3 was found to significantly predict coronary artery disease.Conclusions: Gal-3 concentrations correlated with CAD's presence and severity. We recommend the integration of Gal-3 in the diagnostic, prognostic, and predictive modules of CAD.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Osman,

Algamal,

Elshal

et al. 2024

Ain Shams Medical Journal

View full text Add to dashboard Cite

show abstract

“…Поскольку атеросклероз -прогрессирующее заболевание, можно предположить существование корреляции между уровнем маркеров воспаления и выраженностью атеросклеротического процесса в КА. Например, в работе Soltan G, et al (2020) у пациентов с острым и хроническим коронарным синдромом отмечалась тенденция к увеличению сывороточной концентрации галектина-3 в зависимости от количества вовлеченных КА [16].…”

Section: предоперационный периодunclassified

Inflammatory continuum in the pathogenesis of atrial fibrillation after coronary bypass surgery

Mingalimova

Drapkina²,

Sagirov

et al. 2022

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Atrial fibrillation (AF) after coronary bypass surgery is recorded in 20- 60% of patients and increase the early and long-term postoperative mortality. The aim of the review is to analyze the studies on causal relationships between damaging factors and the development of myocardial inflammation at each stage of surgical treatment in patients with multivessel coronary artery disease. In the review, myocardial inflammation is considered from the point of view of a continuum — a chronic process that originates from the coronary endothelium damage and continuously proceeds within the AF pathogenesis after coronary bypass surgery. For the first time, the concept of inflammatory continuum for postoperative AF is introduced. The review discusses the main and latest laboratory and instrumental markers of local and systemic inflammatory response, which are informative in terms of severity and promising for improving approaches to the diagnosis and prevention of postoperative AF. The review was prepared using available materials from Russian and foreign library databases (PubMed, Medline, Web of Science and Cochrane Library). The search depth was >25 years since 1996. Based on the analysis of available studies, we concluded that inflammation is not just evidence of AF, but plays a causal role in its pathogenesis at each stage of surgical myocardial revascularization.

show abstract

Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review

Abubakar,

Irfan,

Abdelkhalek

et al. 2024

J. Cardiovasc. Transl. Res.

View full text Add to dashboard Cite

Galectin 3 Level in Patients with Acute Coronary Syndrome and its Relation to Severity of Coronary Artery Disease

Cited by 5 publications

References 22 publications

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Correlation between coronary artery disease and Galectin 3 serum level: Angiographic based study

Inflammatory continuum in the pathogenesis of atrial fibrillation after coronary bypass surgery

Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review

Contact Info

Product

Resources

About