2023
DOI: 10.1101/2023.10.30.564706
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Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activity

Guus Franken,
Jorge Cuenca-Escalona,
Isabel Stehle
et al.

Abstract: To initiate adaptive immune responses, dendritic cells (DCs) migrate long distances to transport antigens from peripheral tissues to draining lymph nodes employing a so-called ameboid migration mode. Despite its critical importance, the specific molecular mechanisms that regulate DC migration are poorly characterised. Galectins, a family of β-galactoside-binding proteins, constitute a novel mechanism of membrane organisation at the cell surface and, in this way, exert crucial roles in multiple physiological an… Show more

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