Gallbladder carcinoma: the role of p53 protein overexpression and Ki‐67 antigen expression as prognostic markers

Grau, Luis Antonio Hidalgo; Badia, Josep M.; Salvador, Carmen Admella; Monsó, T Soler; Canaleta, Josep Feliu; Nogués, Josep M Gubern; Sala, Javier Suñol

doi:10.1080/13651820410025110

Cited by 25 publications

(11 citation statements)

References 36 publications

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“…Both the above evidences suggest that squamoid part of adenosquamous cell carcinoma is more aggressive than the adenocarcinoma component. In a study by Hidalgo et al, Ki-67 protein expression in gall bladder carcinoma was not related to histological differentiation, level of GB cancer invasion or patient survival [22].…”

Section: Discussionmentioning

confidence: 87%

Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers

Gulwani

Gupta

Kaur

2017

Indian J Surg Oncol

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Adenosquamous/squamous cell carcinoma (AS/SCC) of the gall bladder is a rare histopathologic subtype that accounts for 1 to 12% of all the gall bladder carcinomas (GBC). Literature on these malignancies is limited. A retrospective analysis of 8 cases (study group) of pathologically proven AS/SCC of the gallbladder among 94 patients who underwent surgery for GBC from January 2001 to December 2014 was done. Twenty-four conventional gall bladder adenocarcinoma cases were selected as control group after matching for age and gender. Mean patient age was 57.8 years and six were females. Clinical presentation did not seem to be too different among the study and control group. Average tumor thickness was significantly higher in AS/SCC cases as compared to the control group (mean 3.1 versus 1.44 cm; = 0.001). Immunohistochemistry for Ki-67 in adenosquamous carcinoma of the gall bladder showed much higher proliferative index in squamoid area than the adenocarcinoma areas (mean 31.3 versus 16.8%; = 0.0004). Study group showed 87.5% patients were in higher stage whereas only 37.5% of the patients in control group presented at a higher stage. AS/SCC of the gall bladder presented at an advanced stage. Higher proliferation index in squamous component of adenosquamous carcinomas may account for higher T stage in these malignancies.

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Section: Discussionmentioning

confidence: 87%

Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers

Gulwani

Gupta

Kaur

2017

Indian J Surg Oncol

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“…Another study by Hidalgo Grau et al . [ 50 ] has not shown any correlation of Ki-67 expression with histological differentiation and survival.…”

Section: Discussionmentioning

confidence: 99%

Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma

Doval¹,

Azam²,

Sinha³

et al. 2014

J Carcinog

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Background:The present study observed the expression levels of epidermal growth factor receptor (EGFR), p53, Bcl2, vascular endothelial growth factor (VEGF), cyclooxygenase-2 (cox-2), cyclin D1, human epidermal receptor-2 (HER-2) and Ki-67 in gallbladder carcinoma (GBC) and their association with clinicopathological profiles and disease outcomes.Materials and Methods:Fifty consecutive samples of cholecystectomy/biopsies from GB bed (archived formalin fixed paraffin embedded tissue blocks of different stages of GBC) were included, and patient details related to their demographic profile, investigations, tumor profile, treatment, and follow-up were recorded. Immunohistochemistry was performed to study the expression levels.Results:Overexpression of EGFR, p53, Bcl2, VEGF, cox-2, cyclin D1 and HER-2 was observed as 74%, 44%, 8%, 34%, 66%, 64%, and 4%, respectively. Association of Bcl2 overexpression in mucinous morphology (40%, P = 0.045), cox-2 overexpression in early stage (I/II) tumors (87.5%, P = 0.028) and VEGF overexpression in alive patients (47.1%, P = 0.044) was observed. Co-expression of EGFR and p53 were statistically significant (P = 0.033). Ki-67 labeling index was significantly higher in patients in age group <40 years (P = 0.027), and poorly differentiated tumors (P = 0.023). Advanced disease and poorly differentiated tumors showed a significantly poor median survival (P < 0.05).Conclusion:EGFR, cox-2 and cyclin D1 were largely overexpressed. Advanced tumor stages and poorly differentiated tumors are predictors of poor survival.

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“…21 In a study conducted by Grau et al on 41 patients of histologically proven cases of GBC, 29 showed p53 poitivity. 22 Roa et al in a study of 157 primary gall bladder carcinoma, found p53 expression in 45% cases. 23 In an Indian study conducted on 78 patients of GBC by Chaube et al p53 positivity was found in only 20% of patients.…”

Section: Discussionmentioning

confidence: 95%

Histopathological study of gall bladder malignancies with special reference to p53 expression

Kaur¹,

Agrawal²,

Garg³

et al. 2020

IJPO

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Few studies have been performed to evaluate the p53 protein expression in gallbladder carcinoma and its relationship to histopathological grade of the tumor. Based on these facts the aim of our study was to assess the p53 overexpression in correlation to the grade of tumor. Material and Methods: 80 cases of histologically proven gall bladder carcinoma were included in the study.p53 immunostaining was done and score was calculated. Results: It was observed that out of 80 cases of gall bladder malignancy, 30(37.5%) cases were p53 positive and 50(62.5%) were p53 negative. There was statistically significant difference between the histological grade of p53 positive and p53 negative adenocarcinomas with significantly higher number of patients of p53 overexpression presenting with poorly differentiated adenocarcinomas. Conclusion: p53 overexpression has inverse relationship with the grade of the tumor.

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Gallbladder carcinoma: the role of p53 protein overexpression and Ki‐67 antigen expression as prognostic markers

Abstract: p53 protein nuclear overexpression and Ki-67 protein expression in gallbladder carcinoma were not related to histological differentiation, level of gallbladder wall invasion or patient survival.

Cited by 25 publications

References 36 publications

Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers

Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers

Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma

Histopathological study of gall bladder malignancies with special reference to p53 expression

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