Gallbladder Disease among Obese Patients in Taiwan

Liew, Phui Ly; Wang, Weu; Lee, Yi Chih; Huang, Ming Te; Lin, Yang; Lee, Wei Jei

doi:10.1007/s11695-007-9068-4

Cited by 36 publications

(34 citation statements)

References 34 publications

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“…A prospective study by Sheen and Liaw [20] showed a linear trend toward the prevalence of cholecystolithiasis increased with the progression of liver disease, i.e., from "healthy" HBsAg carrier through chronic hepatitis to liver cirrhosis. Chronic hepatitis B seems to be a risk factor for gallbladder disease [28]. Paradoxically, chronic hepatitis B was not a risk factor in the development of NASH [21] and HBsAg-positive subjects had less prevalence of metabolic syndrome than HBsAgnegative subjects [32].…”

Section: Discussionmentioning

confidence: 96%

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Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

et al. 2008

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The prevalence of NASH in gallbladder disease was 18% in morbid obese population. We concluded that age, serum cholesterol, and low-density lipoprotein cholesterol levels were risk factors associated with gallbladder disease and fatty liver disease. Insulin resistance was more common in concurrent NASH and gallbladder disease. The mechanism between insulin resistance, fibrosis stage, NASH, and gallbladder disease is unknown.

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Section: Discussionmentioning

confidence: 96%

“…The prevalence of NASH and gallbladder disease was 33.8% [21] and 10.1% [28], respectively, among obese population in Asia. In this study, we first compared the clinical risk factors between NASH and gallbladder disease among morbid obesity that had fatty liver disease undergoing bariatric surgery.…”

Section: Discussionmentioning

confidence: 97%

Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

et al. 2008

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“…Moreover the Systolic BP was also greater than 130 in 55.30%. Reason being people with hypertension may have more sympathetic nerve activities that may probably decrease bowel movements [31].…”

Section: Discussionmentioning

confidence: 99%

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

Ahmed

Baloch

Memon

et al. 2017

Annals of Medicine &Amp; Surgery

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ObjectiveRecognition of Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome in patients with gallstones undergoing laparoscopic or open cholecystectomy, along with it we will also study the life style of patients with gall stones.BackgroundPatients with gallstones have associated NAFLD, with concurrent metabolic syndrome and these ailments share similar factors for example obesity, hypertriglyceridemia and diabetes mellitus. Factors like body mass index, gender, raised lipid levels, use of contraceptives and alcohol and having diabetes, physical inactiveness, multiparous women, water with excessive iron content, metabolic syndrome, and NAFLD are accountable factors for gallstones formation.MethodologyThis was a case series done at Surgical Unit 1 of Civil Hospital Karachi. Selective samples of 88 patients were included. Duration was 3 months. We included both sexes with ultrasound proof of gall stone irrespective of cholecystitis. Excluded patients with history of seropositive viral hepatitis, autoimmune and wilson's disease. As these conditions can act as a confounder to our variables.ResultsNafld was present in 62.5%(n = 55) while 28.4% (n = 25) had metabolic syndrome. 26.94% had BMI less than 18, 32.12 had BMI between 18 and 25 and majority had BMI greater than 25 i.e in 40.93%. Of all 46.6% had a family history of cholelithiasis. Gallstone patients with NAFLD reported about their first degree relative being suffering from cholelithiasis at a significant p-value of 0.034 while this was not significant in cases of metabolic syndrome and the p -value was 0.190.ConclusionWe found association of metabolic syndrome with gallstones and NAFLD. Non alcoholic fatty liver was highly prevalent in our study subjects. Huge percentage of first degree relatives of gall stone patients had gallstones and this relation was more pronounced patients who had associated NAFLD.

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“…A previous study indicated that cholelithiasis in Asian obese patients is significantly associated with increased diastolic blood pressure. It is possible that people with hypertension may have more sympathetic nerve activities that easily inhibit bowel movement and cause GSD [18]. …”

Section: Discussionmentioning

confidence: 99%

The association of metabolic syndrome and its factors with gallstone disease

Lin

Yang

et al. 2014

BMC Fam Pract

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BackgroundTo investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.MethodsWe conducted a cross-sectional study during 2011 ~ 2012. A total of 12050 subjects who completed a questionnaire and underwent physical examination, laboratory tests and abdominal ultrasonography formed the study population.ResultsThe prevalences of metabolic syndrome and gallstone disease were 24.09% and 6.16%. In an age- and sex-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease (OR = 1.61; P < 0.0001). Age, abdominal obesity, and lower high-density lipoprotein cholesterol were associated with gallstone disease after adjusting for other factors. Females had a higher odds ratio than males in waist circumference for GSD, whereas males had a lower odds ratio than females in HDL-C for GSD.ConclusionsThe present study suggests that metabolic syndrome is related to gallstone disease. Waist circumference and high-density lipoprotein cholesterol are all associated with GSD. Men and women may possibly have different priorities and strategies to reduce the burden of GSD.

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Gallbladder Disease among Obese Patients in Taiwan

Cited by 36 publications

References 34 publications

Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

An observational study on the association of nonalcoholic fatty liver disease and metabolic syndrome with gall stone disease requiring cholecystectomy

The association of metabolic syndrome and its factors with gallstone disease

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