Gallbladder motility in sheep: effects of cholecystokinin and related peptides

Ruckebusch, Y.; Soldani, Giulio

doi:10.1111/j.1365-2885.1985.tb00955.x

Cited by 10 publications

(10 citation statements)

References 13 publications

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“…Administration of CCK-OP in 20-fold higher amounts than of cerulein, considered to be of similar potency (Romaƒski 2004), evoked stronger effect on MR incidence as compared with the effect of cerulein. Ruckebusch and Soldani (1985) found that 10-fold lower cerulein dose than CCK-OP evoked even stronger gallbladder contractile response. These doses were similar to those used in the present study.…”

Section: Discussionmentioning

confidence: 87%

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski¹

2007

Acta Vet. Brno

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Cholecystokinin (CCK) can affect phasic contractions and the minute rhythm (MR) in ovine duodenum but its effect on the tonic component remains unclear. Thus, the aim of this study was to assess whether the hormone exerts significant changes on phasic and tonic components of the duodenal motor activity and on phasic and tonic components of the duodenal MR. Mechanical and electrical activities of the duodenum were recorded in four sheep before and after slow intravenous cholecystokinin octapeptide (CCK-OP, doses 20, 200 and 2000 ng/kg b.w.) and cerulein (doses 1, 10 and 100 ng/kg b.w.) administration in the course of phase 2b of the migrating motor complex. During 5-20-minute periods the area under contraction curve for phasic, tonic and total motor activity was measured for the whole curve and separately for the MR-related activity. It was found that both CCK peptides stimulate phasic and tonic components of the duodenal motor activity as well as both these components of the duodenal MR. The effect of CCK peptides on the tonic component was stronger than on the phasic component. These effects were similar in non-fasted and fasted animals. CCK-OP evoked slightly greater effect than cerulein. The effects of these CCK peptides on phasic and tonic components of the MR were similar. It is concluded that CCK-OP and cerulein stimulate both phasic and tonic components of the duodenal motor activity and phasic and tonic components related to the MR in sheep. , small bowel, myoelectrical and motor activity, cholecystokinin Ruminants

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Section: Discussionmentioning

confidence: 87%

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski¹

2007

Acta Vet. Brno

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“…The administration of CCK-OP in 20-fold higher dose than that of cerulein, which is considered to be of similar potency (Romań ski, 2004), evoked, however, a stronger effect on the incidence of the MR as compared with the cerulein effect. Yau et al (1974) suggested that CCK-OP and cerulein are equipotent, while Ruckebusch and Soldani (1985) found that a 10-fold lower cerulein dose than CCK-OP evoked an even stronger gallbladder contractile response. These doses were similar to those used in the present study.…”

Section: Discussionmentioning

confidence: 99%

Cholecystokinin-dependent selective inhibitory effect on ‘minute rhythm’ in the ovine small intestine

Romanski

2009

Animal

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Cholecystokinin (CCK) can exert multiple actions on intestinal motility but its effect on the small-intestinal 'minute rhythm' (MR) is virtually unknown. Therefore, the electrical activity from the abomasal antrum, duodenal bulb, duodenum, jejunum and ileum was continuously recorded in six sheep before, during and after slow intravenous administration, of three doses each, of cholecystokinin-octapeptide (CCK-OP) and cerulein. In four of these sheep, two additional electrodes and the strain gauge force transducer were also inserted in the duodenum. Chronic experiments were performed in the fasted and non-fasted animals and saline or CCK peptides were injected during phases 1, 2a or 2b of the duodenal migrating myoelectric complex (MMC). The administration of both CCK peptides in various doses evoked an inhibitory effect mostly in the duodenal bulb, except for the lowest dose of cerulein. The effects of 20 times greater doses of CCK-OP than that of cerulein were more pronounced. The introduction of both CCK peptides during phase 1 of the MMC produced no marked or significant response. In non-fasted animals, the effects of both hormonal peptides, given during phase 2b of the MMC, were often stronger than those given during phase 2a, while in fasted animals the effects of CCK peptides, administered in the course of phases 2a and 2b of the MMC, were similar. Both higher doses of CCK peptides increased the number of spike bursts within the given MR pattern in the duodenum and decreased the incidence of MR mostly in the duodenal bulb. The inhibitory effects of both CCK peptides on the bulbar MR exhibited a dose-response character, though the lowest dose often evoked the slight stimulatory response. It is concluded that CCK principally exerts an inhibitory effect upon the MR in the duodenal bulb and modifies the MR in the duodenum by increasing the spike burst number in a given MR pattern. Both these actions of CCK peptides seem to be physiological. There is a positive relationship between the intensity of the refractory period and the demonstrated effect of CCK in the duodenum.

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“…Insufflation of the rumen with gas has increased the incidence of secondary rumen contractions in conscious (196) and in decerebrate sheep (182). The occurrence of reticulum contractions has an inhibitory effect on secondary rumen contractions, especially those of the ventral sac and the ventral blind sac that usually end a secondary cycle, allowing the new primary rumen cycle to occur in its normal and usual sequence.…”

Section: Events Associated With Eructationmentioning

confidence: 99%

“…Similarly, tension receptors in the duodenum are presumably responsible for the inhibition of reticuloruminal motility that occurs during duodenal distension (35,196).…”

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confidence: 99%