Gallbladder polyps: modern approaches to diagnostics and treatment

Онучина, Е. В.

doi:10.26442/00403660.2021.01.200544

Cited by 5 publications

(2 citation statements)

References 38 publications

(40 reference statements)

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“…A review of studies investigating the indications for surgical treatment of GBP suggested that the most common indications were coexistence with gallstones and the patient being symptomatic [19,20]. In our research, 35.1% of the patients referred for surgical treatment showed coexistence with gallbladder stones, and 33.3% were symptomatic.…”

Section: Discussionsupporting

confidence: 44%

Surgical indications and histopathologic results analysis of gallbladder polyps: A single-center experience

Ucaner,

Cimen

2024

Med-Science

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Gallbladder polyps (GBP) are solid lesions originating from the gallbladder mucosa and extending into the gallbladder lumen. Preoperative diagnosis of GBP can be easily performed via USG; however, which patients should be followed up and which patients should be operated on is still a matter of discussion. This study aimed to investigate the histopathologic results and indications for surgery in patients diagnosed with GBP in the preoperative period and to present our clinical experience in light of current literature. Patients diagnosed with GBP and who had surgery in our general surgery clinic between July 2019 and July 2023 were retrospectively reviewed. A total of 57 patients were included in the study. The medical records, laboratory results, imaging results, and pathology reports of the patients were examined. The mean age of the patients was 47.1±11.7 years (23-78 years). The male/female ratio was 1.3/1. Polyp diameter was above 10 mm in 61.4% of patients and below 10 mm in 38.6%. The indication for surgery was the presence of coexisting cholelithiasis in 35.1% of the cases, symptomatic polyps in 33.3%, and increased polyp diameter in 21.1%. In histopathologic evaluation, cholesterol polyp was the most frequently encountered polyp (40.4%). The follow-up and treatment of GBP is still controversial. The most important factors to be considered in the surgical treatment of SCP are the polyp being over 10 mm and being symptomatic. In follow-up patients, further detailed clinical examination should be performed if necessary, and other imaging modalities should be preferred along with USG. Furthermore, it is required to establish up-to-date international algorithms for the follow-up and treatment of GBP.

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Section: Discussionsupporting

confidence: 44%

Surgical indications and histopathologic results analysis of gallbladder polyps: A single-center experience

Ucaner,

Cimen

2024

Med-Science

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“…Полипоз желчного пузыря (ПЖП) представляет собой одно из малоизученных заболеваний. Распространенность полиповидных образований желчного пузыря среди населения составляет от 1,5 до 9,5%, при этом выявление данной патологии в последние годы существенно увеличилось [1,2,3]. Последнее очевидно связано с совершенствующимся процессом инструментальной диагностики.…”

Section: актуальностьunclassified

Surgical aspects in treatment of gallblader parenchymatous polyps

Galimov,

Sataev,

Khanov

et al. 2023

jour

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Aim of this work is to pay attention to tactical approaches to patients with gallbladder polyps. Materials and methods. Authors analyze the experience of surgical treatment of 84 patients with gallbladder polyps for the period 2015-2021 yy. at the University Clinic. Results. Histological examination showed that hyperplastic polyps met most frequently in 47.6%, adenomatous polyps occurred in 45.3% and cholesterol (cholesterosis) in 7.1%. Conclusions. Gallbladder polyps have no specific symptoms. The potential for malignant transformation implies an active surgical approach, which leads to an increase in the number of surgical benefits. At the same time, minimally invasive, videoendoscopic technologies have sufficient capabilities for the radical removal of gallbladder polyps.

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Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

Wang,

Qu,

Zeng

et al. 2024

Preprint

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Background With the rising diagnostic rate of gallbladder polypoid lesions (GPLs), differentiating benign cholesterol polyps from gallbladder adenomas with a higher preoperative malignancy risk is crucial. This study aimed to establish a preoperative prediction model capable of accurately distinguishing between gallbladder adenomas and cholesterol polyps using machine learning algorithms. Materials and Methods We retrospectively analysed the patients' clinical baseline data, serological indicators, and ultrasound imaging data. Using 12 machine learning algorithms, 110 combination predictive models were constructed. The models were evaluated using internal and external cohort validation, receiver operating characteristic curves, area under the curve (AUC) values, calibration curves, and clinical decision curves to determine the best predictive model. Results Among the 110 combination predictive models, the Support Vector Machine + Random Forest (SVM + RF) model demonstrated the highest AUC values of 0.972 and 0.922 in the training and internal validation sets, respectively, indicating an optimal predictive performance. The model-selected features included gallbladder wall thickness, polyp size, polyp echo, and pedicle. Evaluation through external cohort validation, calibration curves, and clinical decision curves further confirmed its excellent predictive ability for distinguishing gallbladder adenomas from cholesterol polyps. Additionally, this study identified age, adenosine deaminase level, and metabolic syndrome as potential predictive factors for gallbladder adenomas. Conclusion This study employed the latest machine learning combination algorithms and preoperative ultrasound imaging data to construct an SVM + RF predictive model, enabling effective preoperative differentiation of gallbladder adenomas and cholesterol polyps. These findings will assist clinicians in accurately assessing the risk of GPLs and providing personalised treatment strategies.

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Gallbladder polyps: modern approaches to diagnostics and treatment

Cited by 5 publications

References 38 publications

Surgical indications and histopathologic results analysis of gallbladder polyps: A single-center experience

Surgical indications and histopathologic results analysis of gallbladder polyps: A single-center experience

Surgical aspects in treatment of gallblader parenchymatous polyps

Establishing a Preoperative Predictive Model for Gallbladder Adenoma and Cholesterol Polyps Based on Machine Learning: A Multicentre Retrospective Study

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