Gallbladder Volume in Adults and Its Relationship to Age, Sex, Body Mass Index, Body Surface Area and Gallstones

The purpose of this study was to examine a previous increase in male gallstone disease and to consider the burden of gallstones in a necropsy study with matched controls over a decade. Gallstone prevalence in 5,050 males fell from 20.2% to 19.1% (P=0.022) and in 4,125 females fell from 30.4% to 29.0% (P=0.03). Female gallstone subjects had a higher BMI than controls 24.5 vs. 23.3 (P<0.01), but males did not. Gallstones were twice as common in diabetics, but not with coronary heart disease (CHD). A third of elderly patients of both sexes had gallstones, but cholecystectomy was more common in females, 17:10%. Gallstone-related mortality was 0.7%. The prevalence of gallstones fell slightly. The association between gallstones and diabetes was confirmed, but not for CHD, and for BMI this was confined to females. Gallstones are very common in the elderly, but most are unoperated and seldom cause death.

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“…Increasing age may contribute to the development of gallstones by the increase in dilatation and therefore volume of the gallbladder [29].…”

Section: Discussionmentioning

confidence: 99%

A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

et al. 2009

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“…In a study regarding volume of gallbladder CaroliBosc 27 found that the volume of the gallbladder was increased significantly in subjects over 50 years. They also found a positive correlation between gallbladder volume and body surface area.…”

Section: Discussionmentioning

confidence: 99%

Study of the Morphological Characteristics of the Human Gallbladder in Relation to Age and Sex of Bangladeshi People

Rahman¹,

Akhter

Anwar

et al. 2014

Bangla. J. Anat.

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Context: Variations in the morphology of the gallbladder have long been debated by the abdominal surgeons. So it is important for the surgeons to appreciate the possible anatomical variations that can be encountered during surgery to prevent post operative complications during cholecystectomy. This study was aimed at to find out any variations in the morphology of the postmortem gallbladder in adult Bangladeshi male and female to find out any difference in the gallbladder morphology in relation to age and sex. Material & methods: This study was done on sixty (60) human postmortem gallbladder from Bangladeshi male and females of two age groups- group A age between 20-40 years and group B age between 41-65 years. Among the morphological parameters length, breadth, thickness and volume of the gallbladders were measured. Result: Result of the present study showed that the mean values of gross morphological features of the gall bladder (length, breadth, thickness, volume & weight), were higher in group B than group A except the thickness in female which show somewhat higher mean value in group A than group B. The result showed significantly high value for length and volume in case of male only (p<.05) in group B than group A. When comparison were made between these values in regard of sex, it was found that males of group B showed higher mean value for all parameters than females of group B and result showed a significantly higher value for the length of gallbladder(p<.05). But in case of group A, whereas male had higher mean value for length and weight and, female had higher mean value for breadth, thickness and volume though no values were significantly different. Conclusion: The higher mean values of different parameters of the gallbladder in elderly males and also from their female counterparts of the same age groups may be due to shorter size of the females. Again some parameters showed higher values in females (breadth, thickness and volume) which may indicate the predominance of cholelithiasis in females. Again most of the values in male and female of elderly were higher than the younger groups indicate the formation of gallstones in elderly. DOI: http://dx.doi.org/10.3329/bja.v11i2.20676 Bangladesh Journal of Anatomy, July 2013, Vol. 11 No. 2 pp 81-85

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“…Generally, GBS are often a complication of diseases such as metabolic disorders (diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia), and/or obesity, intestinal diseases, Gilbert's disease, cirrhosis, postvalvular replacement, and hemolytic diseases [8][9][10][11][12][13] . In liver cirrhosis, post-valvular replacement, and hemolytic diseases, bilirubin stone formation is enhanced due to bilirubin overproduction, caused mainly by hemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…In Turkey, the reported prevalence of GBS varies from 5.25 [6] to 10.5% in patients with gastrointestinal complaints and dyspepsia [7] . In many studies, GBS have been found to be related to sex, age, obesity, diabetes mellitus, pregnancy, use of oral contraceptives, genetic factors, intestinal diseases, cirrhosis and hemolytic diseases [8][9][10][11][12][13] . In this context, the prevalence of gallstones increases with age.…”

mentioning

confidence: 99%

Prevalence of Gallstones in Patients with Chronic Myelocytic Leukemia

Ateş

Erkurt²,

Karıncaoğlu³

et al. 2009

Med Princ Pract

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Objective: The aim of the present case-control study was to determine whether or not the prevalence of gallbladder stones (GBS) was increased in patients with chronic myelocytic leukemia (CML) and to investigate clinical and laboratory characteristics of CML patients with GBS. Subjects and Methods: This study included 56 patients with CML and 55 sex- and age-matched healthy controls. All participants underwent abdominal ultrasonography and the main clinical and laboratory characteristics were recorded. Results: Gallbladder stones were detected in 13 (23.6%) patients with CML and in 3 (5.4%) control individuals (p < 0.05). The mean follow-up period of CML patients after diagnosis was 54.6 months, range 3–120 months. Hemoglobin levels were higher in the control group than in CML patients. However, total bilirubin, unconjugated bilirubin, lactate dehydrogenase levels, leukocyte and thrombocyte counts, frequency of splenomegaly and hepatomegaly were higher in the CML than in the control group (p < 0.05). Other clinical and laboratory values were not significantly different between the groups. CML patients with and without GBS were also compared for clinical and laboratory values. Age and follow-up period of CML patients after diagnosis were higher in the CML patients with GBS (p < 0.05). Conclusions: Higher prevalence of GBS in CML patients than in healthy controls was detected. We suggest that CML may increase the frequency of GBS, apart from other well-known risk factors. This risk is probably related to increased unconjugated bilirubin, which determines hemolysis, older age and long follow-up period of CML patients after diagnosis.

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Gallbladder Volume in Adults and Its Relationship to Age, Sex, Body Mass Index, Body Surface Area and Gallstones

Cited by 28 publications

References 28 publications

A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

Study of the Morphological Characteristics of the Human Gallbladder in Relation to Age and Sex of Bangladeshi People

Prevalence of Gallstones in Patients with Chronic Myelocytic Leukemia

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