2015
DOI: 10.3892/etm.2015.2923
|View full text |Cite
|
Sign up to set email alerts
|

Gallic acid decreases hepatitis C virus expression through its antioxidant capacity

Abstract: Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti-inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. In addition, numerous studies have reported that antioxidants possess antiviral activities. Hepatitis C virus (HCV) is one of the most important causes of chronic liver diseases worldwide, but until recently, only a small number of antiviral agents had been developed against HCV. Therefore, the present st… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
33
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
5
3

Relationship

1
7

Authors

Journals

citations
Cited by 65 publications
(35 citation statements)
references
References 43 publications
2
33
0
Order By: Relevance
“…Chlorogenic acid and gallic acid have also been demonstrated to suppress the in vitro and in vivo replication of influenza A virus, enterovirus 71 and hepatitis B and C viruses (Ding et al, 2017;Wang et al, 2009;You et al, 2018;Govea-Salas et al, 2016). Chlorogenic acid specifically inhibited the neuraminidase activity of influenza A viruses H1N1 and H3N2 that was the crucial mechanism of chlorogenic acid for blocking the release of progeny virions from infected cells (Ding et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Chlorogenic acid and gallic acid have also been demonstrated to suppress the in vitro and in vivo replication of influenza A virus, enterovirus 71 and hepatitis B and C viruses (Ding et al, 2017;Wang et al, 2009;You et al, 2018;Govea-Salas et al, 2016). Chlorogenic acid specifically inhibited the neuraminidase activity of influenza A viruses H1N1 and H3N2 that was the crucial mechanism of chlorogenic acid for blocking the release of progeny virions from infected cells (Ding et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Chlorogenic acid specifically inhibited the neuraminidase activity of influenza A viruses H1N1 and H3N2 that was the crucial mechanism of chlorogenic acid for blocking the release of progeny virions from infected cells (Ding et al, 2017). Gallic acid served the antioxidant capacity that linked with down-regulating the genomic RNA and proteins expression of hepatitis C virus (Govea-Salas et al, 2016). Therefore, the phenolic acid constituents of Sambucus Formosana Nakai extract, like caffeic acid, chlorogenic acid and gallic acid, play the key antiviral components against HCoV-NL63 and the other viruses.…”
Section: Discussionmentioning
confidence: 99%
“…Gallic acid reduced the level of reactive oxygen species generated by strong oxidizing agent, such as H 2 O 2 , which could inhibit viral replication. This compound attenuates the translation rate of viral proteins or decreases the stability of viral protein [25]. Moreover, gallic acid was reported to inhibit several other viruses such as influenza virus, foodborne viral surrogates, murine norovirus-1, and feline calicivirus-F9 [26,27].…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, gallic acid was reported to inhibit several other viruses such as influenza virus, foodborne viral surrogates, murine norovirus-1, and feline calicivirus-F9 [26,27]. The antiviral activities of gallic acid might be caused by the hydrophobic interaction between the functional group (hydroxyl) and virion components, bind to free radicals and exert an antioxidant effect [25]. …”
Section: Resultsmentioning
confidence: 99%
“…In contrast, for PWR-1E prostate epithelial cells that are not cancerous have no significant change, indicating that GA has a selective toxicity to cancer cells of prostate cancer. Besides, gallic acid treatment was found to diminish the cellular oxidative stress by decreasing ROS (Reactive Oxygen Species) production and hepatocarcinoma cell proliferation and also decrease hepatitis C virus (HCV) replication in Huh7 replicon cells decreasing the expression of nonstructural HCV proteins of the virus [47].…”
Section: Cancer and Bioactive Compoundsmentioning
confidence: 99%