Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Agbo, Matthias Onyebuchi; Witika, Bwalya A.; Parker, Joshua Elijah; Ukekwe, Francis Ikechukwu; Obonga, Wilfred O

doi:10.3329/dujps.v14i2.28502

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…3 ,4,5-tri- O -methyl gallic acid ( 8 ). NMR data were consistent with those previously reported [ 58 ]. ESI-MS (negative mode), m / z 213.0 [M+H] + .…”

Section: Methodssupporting

confidence: 92%

Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Esposito,

Pisanti,

Mauro

et al. 2023

IJMS

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Colocasia esculenta (L.) Schott is a tuberous plant, also known as taro, employed as food worldwide for its renowned nutritional properties but also traditionally used in several countries for medical purposes. In this study, methanolic extracts were prepared from the corms and leaves of Colocasia, subsequently fractionated via molecular exclusion chromatography (RP-HPLC) and their anti-tumor activity assessed in an in vitro model of gastric adenocarcinoma (AGS cells). Vorm extract and isolated fractions II and III affected AGS cell vitality in a dose-dependent manner through the modulation of key proteins involved in cell proliferation, apoptosis, and cell cycle processes, such as caspase 3, cyclin A, cdk2, IkBα, and ERK. To identify bioactive molecules responsible for anti-tumoral activity fractions II and III were further purified via RP-HPLC and characterized via nuclear magnetic resonance (NMR) and electrospray mass spectrometry (ESI-MS) techniques. The procedure enabled the identification of ten compounds including lignans and neolignans, some isolated for the first time in taro, uncommon megastigmane derivatives, and a gallic acid derivative. However, none of the isolated constituents showed efficacy equivalent to that of the fractions and total extract. This suggests that the whole Colocasia phytocomplex has intriguing anti-tumor activity against gastric cancer.

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“…3 ,4,5-tri- O -methyl gallic acid ( 8 ). NMR data were consistent with those previously reported [ 58 ]. ESI-MS (negative mode), m / z 213.0 [M+H] + .…”

Section: Methodssupporting

confidence: 92%

Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Esposito,

Pisanti,

Mauro

et al. 2023

IJMS

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“…This is evident in the percentage antioxidant inhibition elicited from both models. DPPH assay s more sensitive than the phosphomolybdate method since its radical scavenging activity involves donation of hydrogen atom or transfer of an electron to the nitrogen atom to scavenge the radical unlike the phosphomolybdate method [27][28][29] .…”

Section: Antioxidant Assaymentioning

confidence: 99%

Extract and Fractions from Soil Bacteria (Streptomyces canus ATCC 12647) Possess Antimicrobial and Anti-Oxidative Potential in vitro

Odo

Agbo

Osadebe

2022

JJPS

Self Cite

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Streptomyces species are the most prolific producers of antibiotics within the group actinobacteria. The in-vitro antimicrobial and antioxidant activities of the methanol (MeOH) extract and vacuum liquid chromatography (VLC) fractions of a soil bacteria Streptomyces canus ATCC 12647 were evaluated. Agar well diffusion method was used for the antimicrobial assay, while phosphomolybdate and DPPH radical scavenging methods were used for the antioxidant assay. The antimicrobial assay showed remarkable activities against Bacillus subtilis, Staphylococcus aureus, and Candida albicans. Also, the extract and fractions showed good in-vitro antioxidant activities in both models. Our results showed that extract and VLC fractions from bacterial isolate had good antimicrobial and antioxidant activities.

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In vitro and in vivo cysticidal activity of extracts and isolated flavanone from the bark of Prunus serotina : A bio-guided study

et al. 2017

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Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

Cited by 5 publications

References 6 publications

Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Activity of Colocasia esculenta (Taro) Corms against Gastric Adenocarcinoma Cells: Chemical Study and Molecular Characterization

Extract and Fractions from Soil Bacteria (Streptomyces canus ATCC 12647) Possess Antimicrobial and Anti-Oxidative Potential in vitro

In vitro and in vivo cysticidal activity of extracts and isolated flavanone from the bark of Prunus serotina : A bio-guided study

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