Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Zhang, Tingxiu; Ma, Li; Wu, Pengfei; Li, Wei; Li, Ting; Gu, Rui; Dan, Xiaoping; Li, Zhiwei; Fan, Xiaoxuan; Xiao, Zhenliang

doi:10.3892/or.2019.6976

Cited by 62 publications

(51 citation statements)

References 24 publications

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“…In addition, the anticancer and auxiliary effects of GA were observed in NSCLC A549 cells treated with cisplatin. GA inhibited the proliferation and induced the apoptosis in a dual manner, which was associated with upregulated Bax and downregulated Bcl-2 and modulated the JAK/STAT3 signaling [42].…”

Section: Gallic Acidmentioning

confidence: 99%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.

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Section: Gallic Acidmentioning

confidence: 99%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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“…Since then, reports on GA and its derivatives have gradually increased, which has increased awareness in the understanding of GA. In addition to the edible uses of GA and its ester derivatives as flavoring agents and preservatives in the food industry ( 12 , 13 ), there are also various kinds of studies on their biological and pharmacological activities, including antioxidant ( 14 , 15 ), antimicrobial ( 16 , 17 ), anticancer ( 18 , 19 ), anti-inflammatory ( 20 , 21 ), gastroprotective ( 22 – 25 ), cardioprotective ( 26 , 27 ), neuroprotective ( 28 – 30 ), and metabolic disease prevention activities ( 31 – 33 ). To date, however, virtually no published studies exist on the mechanisms of action of GA through the gut microbiome (GM) and immune response.…”

Section: Introductionmentioning

confidence: 99%

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

et al. 2020

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Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. GA and its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies have shown that GA and its derivatives not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, GA has great potential to facilitate natural defense against microbial infections and modulate the immune response. However, the exact mechanisms of GA acts on the GM and immune system remain unclear. In this review, first the physicochemical properties, bioavailability, absorption, and metabolism of GA are introduced, and then we summarize recent findings concerning its roles in gastrointestinal health. Furthermore, the present review attempts to explain how GA influences the GM and modulates the immune response to maintain intestinal health.

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“…The present study demonstrated that GA significantly suppressed the proliferation of HCT116 and HT29 colon cancer cells and accelerated their apoptotic process, which was consistent with the results of previous studies. In previous studies, GA has been indicated to inhibit cell proliferation and invasion of different tumors, such as non-small cell lung cancer (NSCLC) (26,27) and bladder cancer (28). The occurrence of colon cancer is closely associated with the abnormal expression of multiple genes (29).…”

Section: Discussionmentioning

confidence: 99%

Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation

et al. 2021

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The aim of the present study was to investigate the effects of gallic acid (GA) on the proliferation and apoptosis of colon cancer cells and to further clarify the mechanism of GA function associated with SRC and EGFR phosphorylation. HCT116 and HT29 cells were treated with different concentrations of GA for 24 h. Cell proliferation and apoptosis were analyzed using plate clone formation and flow cytometry assays, respectively. In addition, the expression of apoptosis-related proteins was examined by western blotting. Furthermore, the level of STAT3, AKT, SRC and EGFR phosphorylation was analyzed by western blotting and immunofluorescence. Subsequently, the SRC inhibitor PP2 and the EGFR inhibitor gefitinib were used to analyze the GA-associated mechanisms. In addition, a xenograft tumor model was established to confirm the effects of GA in vivo. The results indicated that GA inhibited cell proliferation and promoted cell apoptosis by upregulating the ratio of cleaved caspase-3/pro-caspase-3 and cleaved caspase-9/pro-caspase-9. Concurrently, GA decreased the level of phosphorylated (p)-SRC, p-EGFR, p-AKT and p-STAT3. Following treatment with PP2 and gefitinib in both cancer cell lines and animal model, GA was demonstrated to inhibit EGFR and SRC phosphorylation to downregulate STAT3 and AKT phosphorylation. In vivo, GA prevented tumor growth, promoted tumor apoptosis and decreased the level of p-SRC, p-EGFR, p-STAT3 and p-AKT. In conclusion, GA was indicated to suppress colon cancer proliferation by inhibiting SRC and EGFR phosphorylation.

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Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non‑small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway

Cited by 62 publications

References 24 publications

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action

Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation

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