Gallic acid-loaded HFZIF-8 for tumor-targeted delivery and thermal-catalytic therapy

Yang, Xing; Li, Chunsheng; Liu, Shuang; Li, Yunlong; Zhang, Xinyu; Wang, Qiang; Ye, Jin; Lu, Yong; Fu, Yujie; Xu, Jiating

doi:10.1039/d4nr01102c

Nanoscale

2024

DOI: 10.1039/d4nr01102c

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Gallic acid-loaded HFZIF-8 for tumor-targeted delivery and thermal-catalytic therapy

Xing Yang,

Chunsheng Li,

Shuang Liu

et al.

Abstract: “Life” metal-coordinated plant polyphenol is a type of promising antitumor nanodrugs due to its high biosafety and catalytic therapy potency, while the major obstacle restricting its clinical application is poor...

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2024

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Cited by 2 publications

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Leitão,

Morais

2024

J. Med. Chem.

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Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts for more effective and safer treatments. Rational design and engineering of metal complexes enable the development of tailored molecular structures optimized for precision oncology. The strategic incorporation of metal complex catalysts within combinatorial therapies amplifies their anticancer properties. This perspective highlights the advancements in synthetic strategies and rational design since 2019, showing how tailored metal catalysts are optimized by designing structures to release or in situ synthesize active drugs, leveraging the target-specific characteristics to develop more precise cancer therapies. This review explores metal-based catalysts, including those conjugated with biomolecules, nanostructures, and metal−organic frameworks (MOFs), highlighting their catalytic activity in biological environments and their in vitro/in vivo performance. To sum up, the potential of metal complexes as catalysts to reshape the landscape of anticancer therapies and foster novel avenues for therapeutic advancement is emphasized. ■ SIGNIFICANCE• Metal complexes have been strategically engineered for precision oncology, offering an enhanced efficacy with reduced side effects. • Rational design and engineering of metal complexes enables the creation of customized molecular structures that release or synthesize active drugs directly at the target site, enhancing the precision of oncology treatments. • Cutting-edge strategies and advancements in drug design that combine metal complexes with advanced catalysis techniques to develop more effective and targeted anticancer drugs are presented.

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Leitão,

Morais

2024

J. Med. Chem.

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Designing injectable dermal matrix hydrogel combined with silver nanoparticles for methicillin-resistant Staphylococcus aureus infected wounds healing

Chen,

Yao,

Huo

et al. 2024

Nano Convergence

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Hydrogel-based delivery systems have now emerged as a pivotal platform for addressing chronic tissue defects, leveraging their innate capacity to suppress pathogenic infections and facilitate expedited tissue regeneration. In this work, an injectable hydrogel dressing, termed AgNPs-dermal matrix hydrogel (Ag@ADMH), has been designed to expedite the healing process of wounds afflicted with methicillin-resistant Staphylococcus aureus (MRSA), featuring sustained antibacterial efficacy. The synthesis of the hydrogel dressing entailed a self-assembly process of collagen fibers within an acellular dermal matrix to construct a three-dimensional scaffold, encapsulated with plant polyphenol-functionalized silver nanoparticles (AgNPs). The Ag@ADMH demonstrated exceptional biocompatibility, and enables a sustained release of AgNPs, ensuring prolonged antimicrobial activity. Moreover, the in vitro RT-qPCR analysis revealed that compared with ADMH, Ag@ADMH diminish the expression of iNOS while augmenting CD206 expression, thereby mitigating the inflammatory response and fostering wound healing. Especially, the Ag@ADMH facilitated a reduction in M1 macrophage polarization, as evidenced by a significant decrement in the M1 polarization trend and an enhanced M2/M1 ratio in dermal matrix hydrogels laden with AgNPs, corroborated by confocal microscopy and flow cytometry analyses of macrophage phenotypes. The in vivo assessments indicated that Ag@ADMH minimized fibrous capsule formation. In a full-thickness skin defect model of MRSA infection, the formulation significantly attenuated the inflammatory response by reducing MPO and CD68 expression levels, concurrently promoting collagen synthesis and CD34 expression, pivotal for vasculogenesis, thereby accelerating the resolution of MRSA-infected wounds. These attributes underscore the injectable extracellular matrix hydrogel as a formidable strategy for the remediation and regeneration of infected wounds. Graphical Abstract

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Gallic acid-loaded HFZIF-8 for tumor-targeted delivery and thermal-catalytic therapy

Abstract: “Life” metal-coordinated plant polyphenol is a type of promising antitumor nanodrugs due to its high biosafety and catalytic therapy potency, while the major obstacle restricting its clinical application is poor...

Cited by 2 publications

References 58 publications

Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Designing injectable dermal matrix hydrogel combined with silver nanoparticles for methicillin-resistant Staphylococcus aureus infected wounds healing

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