Gallium‐67 citrate imaging in underground coal miners

Kanner, R.E.; Hw, Barkman; Rom, William N.; At, Taylor

doi:10.1002/ajim.4700080107

Cited by 11 publications

(2 citation statements)

References 6 publications

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“…In coal pneumoconiosis, it was found in 22 Utah coal workers with more than 20 years of underground coal mining that 67 Ga scans were generally abnormal in most of the studied patients [150] . There was no significant difference in the uptake index between subjects with or without radiographic pneumoconiosis.…”

Section: Gallium-67 Lung Scanmentioning

confidence: 85%

Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis

Begin¹,

Cantin²,

Masse³

1989

Eur Respir J

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Recent investigations of the fundamental mechanisms of the mineral dust diseases have substantially increased our understanding of the pathogenesis of the pneumoconioses. In all the mineral dust pneumoconioses, the initial early lung lesion is a fibrosing macrophagic alveolitis. The additional contribution of other lung cell populations is currently under investigation and may identify specific processes for each of the pneumoconioses. Clinical investigations have also progressed with new tools such as Gallium-67 lung scanning, bronchoalveolar lavage analyses, and CT scanning of the thorax; their established values are reviewed in this paper, and areas where progress is needed are considered. The clinical progress in the mineral dust diseases is clearly linked to the basic understanding of the mechanisms of these diseases.

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Section: Gallium-67 Lung Scanmentioning

confidence: 85%

Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis

Begin¹,

Cantin²,

Masse³

1989

Eur Respir J

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“…SPET with 67 Ga-citrate has been applied for inflammatory disorders evolving in pulmonary fibrosis (e.g., idiopathic pulmonary fibrosis (IPF), lymphoid interstitial pneumonitis), for inhalational and occupational pulmonary diseases, (e.g., asbestosis, berylliosis, coal worker pneumoconiosis), collagen vascular diseases (e.g., systemic lupus erythematosus and systemic sclerosis), and other noninfectious inflammatory disease, including pulmonary alveolar proteinosis, eosinophilic pneumonia, Wegener's granulomatosis, and eosinophilic granuloma [46][47][48][49][50][51][52][53][54][55][56][57][58][59].…”

Section: Gallium-67 Citratementioning

confidence: 99%

Molecular Imaging of Pulmonary Inflammation and Infection

Giraudo

Evangelista

Fraia

et al. 2020

IJMS

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Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and mortality worldwide. Although infrequently used in this setting, molecular imaging may significantly contribute to their diagnosis using techniques like single photon emission tomography (SPET), positron emission tomography (PET) with computed tomography (CT) or magnetic resonance imaging (MRI) with the support of specific or unspecific radiopharmaceutical agents. 18F-Fluorodeoxyglucose (18F-FDG), mostly applied in oncological imaging, can also detect cells actively involved in infectious and inflammatory conditions, even if with a low specificity. SPET with nonspecific (e.g., 67Gallium-citrate (67Ga citrate)) and specific tracers (e.g., white blood cells radiolabeled with 111Indium-oxine (111In) or 99mTechnetium (99mTc)) showed interesting results for many inflammatory lung diseases. However, 67Ga citrate is unfavorable by a radioprotection point of view while radiolabeled white blood cells scan implies complex laboratory settings and labeling procedures. Radiolabeled antibiotics (e.g., ciprofloxacin) have been recently tested, although they seem to be quite unspecific and cause antibiotic resistance. New radiolabeled agents like antimicrobic peptides, binding to bacterial cell membranes, seem very promising. Thus, the aim of this narrative review is to provide a comprehensive overview about techniques, including PET/MRI, and tracers that can guide the clinicians in the appropriate diagnostic pathway of infectious and inflammatory pulmonary diseases.

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Relationship of inflammatory cell cytokines to disease severity in individuals with occupational inorganic dust exposure

Rom

1991

American J Industrial Med

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The pneumoconioses due to chronic occupational exposure to asbestos, coal, or silica are characterized by an alveolar macrophage-dominated alveolitis with exaggerated spontaneous release of mediators: oxidants, chemotaxins for neutrophils, and fibroblast growth factors. Bronchoalveolar lavage was performed on 66 non-smoking inorganic dust-exposed individuals with a chest x-ray greater than or equal to 1/0 stratified by presence or absence of restrictive respiratory impairment, and 28 unexposed non-smoking controls. Both dust-exposed groups stratified by presence or not of impairment had increased numbers of total cells recovered by lavage compared to normals, and those with respiratory impairment (n = 40) had a significant increase in percent and number of neutrophils recovered. Similarly, only those with respiratory impairment had macrophages that spontaneously released significant amounts of the oxidants superoxide anion and hydrogen peroxide. There was a significant trend for the release of fibronectin by macrophages from controls to dust-exposed without impairment to those with impairment. Both dust-exposed groups also had increased release of alveolar macrophage-derived progression growth factor, but this was significantly less than macrophages from patients with idiopathic pulmonary fibrosis. Since occupational exposure was virtually identical in inorganic dust-exposed individuals with versus without respiratory impairment, the quantitative differences in the release of macrophage mediators may be due to factors in host susceptibility.

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Gallium‐67 citrate imaging in underground coal miners

Cited by 11 publications

References 6 publications

Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis

Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis

Molecular Imaging of Pulmonary Inflammation and Infection

Relationship of inflammatory cell cytokines to disease severity in individuals with occupational inorganic dust exposure

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