Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

Kurtuldu, Fatih; Mutlu, Nurshen; Boccaccını, Aldo R.; Galusek, Dušan

doi:10.1016/j.bioactmat.2021.12.034

Cited by 70 publications

(54 citation statements)

References 157 publications

(294 reference statements)

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“…Gallium compounds have long been used as anticancer drugs. Recently, the anti-infective effect of gallium has been gradually discovered [ 140 , 141 ]. The antibacterial activity of gallium originates from its chemical similarity to iron.…”

Section: Novel Immune-enhanced Antimicrobial Strategiesmentioning

confidence: 99%

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

et al. 2022

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Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

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Section: Novel Immune-enhanced Antimicrobial Strategiesmentioning

confidence: 99%

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

et al. 2022

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“…Materials of Institute Lavoisier frameworks (MILs) are a kind of MOF with good water stability, making them promising adsorbents for heavy metal ions in water [ 31 , 32 ]. Moreover, the central metal of MIL-68, Ga 3+ has been demonstrated to play a key role in the biomedical field, such as anticancer, antibacteria, and hemostasis [ 33 , 34 ]. Until now, there have been few studies on gallium-based MOFs as adsorbents for heavy metal ion removal [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Magnetic MIL-68(Ga) Metal–Organic Framework and Heavy Metal Ion Removal Application

Zhang

Liu²,

et al. 2022

Molecules

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A magnetic metal–organic framework nanocomposite (magnetic MIL-68(Ga)) was synthesized through a “one pot” reaction and used for heavy metal ion removal. The morphology and elemental properties of the nanocomposite were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), as well as zeta potential. Moreover, the factors affecting the adsorption capacity of the nanocomposite, including time, pH, metal ion type and concentration, were studied. It was found that the adsorption capacity of magnetic MIL-68(Ga) for Pb2+ and Cu2+ was 220 and 130 mg/g, respectively. Notably, the magnetic adsorbents could be separated easily using an external magnetic field, regenerated by ethylenediaminetetraacetic acid disodium salt (EDTA-Na2) and reused three times, in favor of practical application. This study provides a reference for the rapid separation and purification of heavy metal ions from wastewater.

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“…Mg 2+ ion is also involved in the blood coagulation cascade by assisting the stabilization of the native conformation of factor IX [ 150 ]. Other metals (Ag, Ga and Ce) have also been used for the design of hemostatic materials [ 86 , [151] , [152] , [153] ]. In conclusion, the hemostatic properties may be improved by the virtue of electric charge and metal ions, though the impact of such modifications on the antibacterial ability, hemocompatibility, cell activity of the materials should also be considered.…”

Section: Molecular Structure Design Of the Hemostasis Materialsmentioning

confidence: 99%

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Zou¹,

Li²,

Hu³

et al. 2022

Materials Today Bio

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Gallium containing bioactive materials: A review of anticancer, antibacterial, and osteogenic properties

Cited by 70 publications

References 157 publications

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Preparation of Magnetic MIL-68(Ga) Metal–Organic Framework and Heavy Metal Ion Removal Application

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

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