Galloyl derivatives from Caesalpinia coriaria exhibit in vitro ovicidal activity against cattle gastrointestinal parasitic nematodes

García-Hernández, César; Rubio, Rolando Rojo; Olmedo-Juárez, Agustín; Zamilpa, Alejandro; Gives, Pedro Mendoza de; Antonio-Romo, I.A.; Aguilar-Marcelino, Liliana; Arece-García, Javier; Tapia‐Maruri, Daniel; González-Cortazar, Manasés

doi:10.1016/j.exppara.2019.03.012

Cited by 32 publications

(18 citation statements)

References 32 publications

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“…We hypothesize that methanolic extracts may allow to obtain more compounds associated with the ovicidal activity or may contain less compounds that antagonize with that activity. Such difference could be related to the polarity of extracts (Cortés-Morales et al ., 2019; García-Hernández et al ., 2019). Additionally, a recent study showed that the ovicidal activity was less evident for extracts with lower-condensed tannin content (Castañeda-Ramírez et al ., 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of different extracts of threeAnnonaspecies on egg-hatching processes ofHaemonchus contortus

et al. 2019

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This study assessed the in vitro anthelmintic (AH) activity of methanol and acetone:water leaf extracts from Annona squamosa, A. muricata and A. reticulata against Haemonchus contortus eggs. The egg hatch test was used to determine the effective concentrations required to inhibit 50% of eggs hatching (EC50). The role of polyphenols on AH activity was measured through bioassays with and without polyvinylpolypyrrolidone (PVPP). Methanolic extracts mainly caused the death of eggs at the morula stage (ovicidal activity). Meanwhile, acetone:water extracts caused egg-hatching failure of developed larvae (larvae failing eclosion (LFE) activity). The lowest EC50 values against H. contortus eggs were observed for the methanolic extracts from A. reticulata and A. muricata (274.2 and 382.9 µg/ml, respectively). From the six extracts evaluated, the methanolic extracts of A. muricata, A. reticulata and A. squamosa showed the highest ovicidal activity, resulting in 98.9%, 92.8% and 95.1% egg mortality, respectively. When the methanolic extract of A. squamosa was incubated with PVPP, its AH activity increased. Similarly, when acetone:water extracts of A. muriata and A. reticulata were incubated with PVPP, their LFE activity increased. Alkaloids were only evident in methanolic extracts, irrespective of PVPP incubation. The presence of acetogenins was not observed. In conclusion, methanolic extracts obtained from leaves of A. muricata, A. reticulata and A. squamosa showed ovicidal activity affecting the morula of H. contortus eggs, with minor LFE activity. Meanwhile, acetone:water extracts showed mostly LFE activity, with a lower proportion of ovicidal activity.

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Section: Introductionmentioning

confidence: 99%

Effects of different extracts of threeAnnonaspecies on egg-hatching processes ofHaemonchus contortus

et al. 2019

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“…However, these authors also showed that methyl gallate had no activity against these parasites. 19 Therefore, the increased efficiency in ovicidal activity (against both parasites species) observed for the hydro-alcoholic extract from C. coriaria leaves in the present study could be associated with its gallic acid content.…”

Section: Egg Hatching Inhibitionmentioning

confidence: 56%

“…1B). García-Hernández et al 19 have previously reported the presence of methyl gallate and gallic acid, as well as other galloyl derivatives, in a hydro-alcoholic extract from C. coriaria fruits. Likewise, Sánchez-Carranza et al 20 found phenolic compounds, including ethyl gallate, gallic acid and tannic acid, in C. coriaria pods.…”

Section: Condensed Tannin and Other Secondary Compound Content In Extmentioning

confidence: 95%

“…36,37 Since PEG was not used in this study, the observed ovicidal effect of C. coriaria extracts cannot be directly attributed to their condensed tannin content, but it could be associated with found gallotannins. 19 Hence, further in vitro studies are warranted (using PEG) to verify if condensed tannin content in extracts from C. coriaria fruits and leaves does in fact have an ovicidal activity.…”

Section: Egg Hatching Inhibitionmentioning

confidence: 99%

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Caesalpinia coriaria fruits and leaves extracts possess in vitro ovicidal activity against Haemonchus contortus and Haemonchus placei

et al. 2019

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The ovicidal effect of hydro-alcoholic extracts from mature fruits and dried leaves of the Caesalpinia coriariatree, against Haemonchus contortus and H. placei was evaluated by the egg hatching inhibition test (EHIT). Secondary compounds within the extracts were identified by high performance liquid chromatography. Five extract concentrations were assessed in the inhibition tests (25.0, 12.5, 6.2, 3.1 and 1.5 mg/mL), using distilled water and Thiabendazole (0.5 mg/mL) as negative and positive controls, respectively. The results were analysed under a 2 × 2 × 6 completely randomized factorial design, and mean differences were established by the Tukey’s post hoc test. The 50% (EC50) and 90% (EC90) effective concentrations for each extract were determined using a Probit analysis.A concentration-dependent ovicidal effect of hydro-alcoholic extracts from both leaves and fruits was observed, reaching a 100% efficacy against both nematode species with the 25.0 mg/mL concentration (p < 0.05). The EC50 for the fruit and leaves extracts were established as 1.63 and 3.91 mg/mL, and as 3.98 and 11.68 mg/mL, against H. contortus and H. placei, respectively. The most important secondary compounds identified in extracts were free-condensed tannins, gallic acid and methyl-gallate.In conclusion,hydro-alcoholic extracts from C. coriaria mature fruits and dried leaves inhibit in vitro egg hatching of H. contortus and H. placei.

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“…Reports indicate that several species of this genus exhibit a wide range of pharmacological properties, including antiulcer, anticancer, antidiabetic, anti-inflammatory, antimicrobial, and antirheumatic activities that could have potential in ethnomedicinal practices (6,7,8). Additionally, it is important to highlight that the richness of the products derived from Caesalpinia species are not only associated with pharmacological use but also agricultural industries (9), animal production (10), and environmental applications for the oil industry (11).…”

Section: Introductionmentioning

confidence: 99%

In vitro antimicrobial activity of Caesalpinia coriaria (Jacq.) Willd extracts on Streptococcus pyogenes and Candida albicans

López-Pazos

Pitre-Ruiz

Galván-Ayala

et al. 2021

Vitae

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Background: “Dividivi” Caesalpinia coriaria (Jacq.) Willd fruits are traditionally used by the Wayuú community in La Guajira (Colombia) to treat oral and skin cavity diseases caused by bacteria and fungi. Streptococcus pyogenes is a gram-positive cocci of group A (beta-hemolytic) that is the cause of pharyngeal disease, scarlet fever, cellulitis, erysipelas, or toxic shock-like syndrome. Alternatively, Candida albicans is a yeast-like fungus that is a normal flora of the digestive tract, vagina, or skin folds; it has been known to be the root cause of opportunistic diseases such as diaper rash, oral and esophagus thrush, or vulvovaginitis. Objective: This study evaluated the antimicrobial activity of methanolic and ethanolic extracts of C. coriaria (Jacq.) Willd dry fruits on S. pyogenes ATCC 12384 and C. albicans ATTC 14053. Method: C. coriaria extracts were obtained from the Soxhlet method using two solvents (methanol and ethanol 98%) prepared from pulverized fruits. A phytochemical test and an antimicrobial activity assay were performed using the obtained extracts and tested using S. pyogenes ATCC 12384 and C. albicans ATTC 14053 strains. Results: A phytochemical profile was performed, examining the presence of bioactive metabolites (tannins, alkaloids, glycosides, saponins, and anthraquinones) from each extract. Antimicrobial susceptibility tests showed that the ethanolic extract inhibited S. pyogenes ATCC 12384, causing inhibition halos of 14.1 ± 0.1 mm and a Minimum Inhibitory Concentration (MIC) of 172 mg/ml, and C. albicans test shows inhibition halos of 16.1 ± 0.2 mm and MIC of 212 mg/ml. Additionally, the methanolic extract inhibited S. pyogenes with inhibition halos of 15.2 ± 0.2 mm and MIC of 152 mg/ml; no inhibitory effect was observed on C. albicans. Conclusion: This study revealed that C. coriaria has an antimicrobial effect on the tested species opening the field of its possible use as a therapeutic agent.

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Galloyl derivatives from Caesalpinia coriaria exhibit in vitro ovicidal activity against cattle gastrointestinal parasitic nematodes

Cited by 32 publications

References 32 publications

Effects of different extracts of threeAnnonaspecies on egg-hatching processes ofHaemonchus contortus

Effects of different extracts of threeAnnonaspecies on egg-hatching processes ofHaemonchus contortus

<em>Caesalpinia coriaria</em> fruits and leaves extracts possess <em>in vitro</em> ovicidal activity against <em>Haemonchus contortus</em> and <em>Haemonchus placei</em>

In vitro antimicrobial activity of Caesalpinia coriaria (Jacq.) Willd extracts on Streptococcus pyogenes and Candida albicans

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