Gallstone and Gallbladder Disease: Biliary Tract and Cholangiopathies

Ceci, Ludovica; Han, Yuyan; Krutsinger, Kelsey; Baiocchi, Leonardo; Wu, Nan; Kundu, Debjyoti; Kyritsi, Konstantina; Zhou, Tianhao; Gaudio, Eugenio; Francis, Heather; Alpini, Gianfranco; Kennedy, Lindsey

doi:10.1002/cphy.c220028

Cited by 5 publications

(1 citation statement)

References 366 publications

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“…Animal studies, including those using diet-induced pigment or cholesterol gallstone models, have revealed that mucin secretion is significantly increased in the biliary system, suggesting a possible role of mucin in gallstone formation. Importantly, in response to a lithogenic diet, an increase in biliary mucin was revealed to occur before the formation of stones [ 21 ], indicating that stone formation should follow an increase in mucin concentration, and mucin may contribute to the formation of stones. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones.…”

Section: Mucin Is Involved In Gallstone Formationmentioning

confidence: 99%

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Zhao,

Yang,

et al. 2024

Biomolecules

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Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence.

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Section: Mucin Is Involved In Gallstone Formationmentioning

confidence: 99%

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Zhao,

Yang,

et al. 2024

Biomolecules

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Association between serum iron and gallstones in US adults: a cross-sectional study

Wen,

Tang,

Tang

et al. 2024

BMC Nutr

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Background Gallstones are a common digestive disorder that threatens human health. Iron deficiency may be related to the formation of gallstones, but there is limited current epidemiological research. The objective of this study was to investigate the relationship between iron status and gallstones. Methods The datasets from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were used in a cross-sectional investigation. Gallstones were determined by using the 2007–2010 NHANES questionnaire. Multivariate linear regression models were used to examine the association between serum iron, serum ferritin and iron intake with the risk for gallstones. Subgroup analysis based on gender, age, race, and diabetes were performed. Fitted smoothing curves were used to describe the linear relationship. Results The research involved 7847 participants aged 20 and above, among whom 845 were identified as having gallstones. Participants with higher serum iron levels tended to have a lower gallstones prevalence. A negative relationship between serum iron and gallstones prevalence was observed (OR = 0.979, 95% CI:0.965–0.992). The group with the highest serum iron tertile had a 23.7% lower risk of gallstones compared to the lowest tertile (OR = 0.763, 95% CI:0.628‒0.929). Gallstone prevalence was inversely correlated with iron intake in model 1. The negative association between serum iron and gallstones remained stable in stratifications, including gender, age, race, and diabetes. Conclusions Elevated serum iron was associated with a decreased prevalence of gallstones. However, to confirm the impact of long-term iron metabolism on gallstone formation, additional prospective research is necessary.

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Biological Mechanisms of Aflatoxin B1-Induced Bile Metabolism Abnormalities in Ducklings

Chu,

Yu,

Wang

et al. 2024

Animals

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This study investigated the effects and biological mechanisms of aflatoxin B1 (AFB1) on the health and bile metabolism of ducklings. Forty-eight 1-day-old ducklings were randomly assigned to two groups, with six replicates per group. The control group was fed a basic diet, while the AFB1 group received a diet containing 90 µg/kg of AFB1. The experiment lasted for 2 weeks. The results showed that 90 µg/kg AFB1 caused abnormal bile metabolism; damaged liver cell nuclei and mitochondria; and significantly decreased body weight, average daily weight gain, and levels of albumin, total protein, cholesterol, total superoxide dismutase, glutathione peroxidase, and glutathione. It also significantly increased feed conversion efficiency, along with alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bile acids, and malondialdehyde levels. In the liver, the expression levels of CYP7A1, SCD, and other genes were significantly upregulated, while BSEP, FASN, HMGCR, CAT, and other genes were significantly downregulated. In conclusion, AFB1 causes abnormal bile metabolism and impairs the overall health and liver function of ducklings. Its mechanism of action may involve changes in gene expression related to bile acid metabolism, lipid metabolism, oxidative damage, and cancer pathways.

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Gallstone and Gallbladder Disease: Biliary Tract and Cholangiopathies

Cited by 5 publications

References 366 publications

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis

Association between serum iron and gallstones in US adults: a cross-sectional study

Biological Mechanisms of Aflatoxin B1-Induced Bile Metabolism Abnormalities in Ducklings

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