The use of immersive and interactive learning environments is gaining traction in science, technology, engineering and mathematics (STEM) education, as educators seek to engage students and enhance learning outcomes. We explore the potential of Metaverse for designing immersive and interactive escape rooms that leverage microlearning to teach STEM concepts and skills. We overview Metaverse and its potential as a learning environment, before delving into the use of escape rooms as a strategy for fostering critical thinking, collaboration, and problem-solving in STEM education. We examine the benefits of incorporating microlearning strategies into escape rooms, including the use of bite-sized content and personalized learning paths. Through a case study of a Metaverse escape rooms implemented in Studio Gometa as a smartphone app and aimed at mathematics education, we highlight the learning outcomes achieved and the challenges faced in the design and implementation process.