Gamma-Aminobutyric Acid Binds to GABAB Receptor to Inhibit Cholangiocarcinoma Cells Growth via the JAK/STAT3 Pathway

Huang, Qiang; Zhu, Chenglin; Liu, Chenhai; Xie, Fang; Zhu, Kai; Hu, Sanyuan

doi:10.1007/s10620-012-2382-2

Cited by 16 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A metabotropic GABA B receptor (GABA B R) is one of the GABA family members, which was originally identified as a major inhibitory neurotransmitter in the adult mammalian brain . Outside the brain, GABA and its receptors have been found in nonneuronal peripheral tissues, such as the gastrointestinal system , lung , and liver , including the biliary tract system .…”

Section: Discussionmentioning

confidence: 99%

“…Outside the brain, GABA and its receptors have been found in nonneuronal peripheral tissues, such as the gastrointestinal system , lung , and liver , including the biliary tract system . Studies have implicated GABA and its receptors as important players not only in synaptic inhibition, convulsion, pain, depression, and cognition , but also in the inhibition of cancer growth and tumor cell migration in, for example, colorectal carcinoma , breast cancer , and cholangiocarcinoma . For example, Zhang D and his lab members found that both the GABA synthetic enzyme (GAD65/67) and GABA B receptor are expressed in mouse and human breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

Shu

Liu

et al. 2016

Cancer Medicine

View full text Add to dashboard Cite

Colorectal cancer is one of the leading causes of highly fatal cancer‐related deaths in the whole world. Fast growth is critical characteristic of colorectal cancer, the underlying regulatory mechanism of colorectal cell fast proliferation remains largely unknown. Here, we reported that activation of metabotropic γ‐Aminobutyric acid receptor (GABABR) signaling significantly inhibited the colorectal cell HT29 proliferation by arresting the cell at G1 phase. Inhibition of GABABR activated GSK‐3β by reducing the phosphorylation level of GSK‐3β. Activation of GSK‐3β blocked the function of GABABR signaling on repressing cell proliferation. We further found that GABABR activation inhibited NF‐κB activity. The promotion of cell proliferation caused by downregulation of GABRBR could be blocked by inhibition of NF‐κB activation. Overall, activation of GABABR leaded to inhibition of GSK‐3β activation to repress the NF‐κB function during colorectal cancer cell proliferation. This study revealed critical function of GABABR/GSK‐3β/NF‐κB signaling pathway on regulating proliferation of colorectal cancer cell, which might provide a potential therapeutic target for clinical colorectal cancer treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

Shu

Liu

et al. 2016

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…γ-aminobutyric acid has potential health benefits such as antidepressant, sedative, antihypertensive, antidiabetic, anticarcinogenic and immune system enhancer [14,24,25,26,27,28,29]. In microorganisms, GABA is involved in spore germination and causes acid resistance in bacteria [30].…”

Section: Introductionmentioning

confidence: 99%

γ-Aminobutyric acid found in fermented foods and beverages: current trends

Sahab

Subroto

Balia

et al. 2020

Heliyon

View full text Add to dashboard Cite

γ-aminobutyric acid (GABA) is synthesised by glutamic acid decarboxylase which catalyses the decarboxylation of L-glutamic acid. L-glutamic acid is formed by α-ketoglutarate in the TCA cycle by glutamic acid dehydrogenase (GDH). GABA is found in the human brain, plants, animals and microorganisms. GABA functions as an antidepressant, antihypertensive, antidiabetic and immune system enhancer and has a good effect on neural disease. As GABA have pharmaceutical properties, conditions for GABA production need to be established. Microbiological GABA production is more safe and eco-friendly rather than chemical methods. Moreover, it is easier to control conditions of production using microorganisms compared to production in plants and animals. GABA production in fermented foods and beverages has the potential to be optimised to increase the functional effect of fermented foods and beverages.

show abstract

“…In addition, it can also exert a calming effect and may be used to treat insomnia, depression, and post-traumatic stress syndrome (PTSD). Previous studies have demonstrated that GABA contributes to the management of stress, pain, and anxiety [ 10 , 11 , 12 , 13 , 14 ]. Injection of 100 and 150 μg/10μL of physiological saline of GABA into mice has been shown to improve their ability in discrimination learning [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Increasing γ-Aminobutyric Acid Content in Vegetable Soybeans via High-Pressure Processing and Efficacy of Their Antidepressant-Like Activity in Mice

Chang

Lai

et al. 2020

Foods

View full text Add to dashboard Cite

This study applied high-pressure processing (HPP) technology to enrich the gamma aminobutyric acid (GABA) content in vegetable soybeans and evaluated its antidepressant efficacy on mice, with depression induced by the unpredictable chronic mild stress (UCMS) model. The optimal conditions for HPP, storage time, and storage temperature, as well as antidepressant-like effects of vegetable soybeans, were evaluated and discussed. HPP could effectively and significantly increase GABA content in soybean, with optimum conditions at 200 MPa. The GABA content in the whole vegetable soybean was 436.05 mg/100 g. In mice animal tests, the tail suspension test (TST) showed that the immobility time of the GABA group was significantly shorter than that of the control group. The total travel distance in the open field test (OFT) showed that depressed mice fed with the GABA feed exhibited exploratory behavior. The GABA group showed a significantly higher degree of sucrose preference than the control group. Both results indicate that the GABA feed could effectively alleviate depressive symptomatology. Regarding biochemical parameters, the fecal and serum corticosterone (CORT) levels in the control group increased to 104.86 pg/mg after the onset of depression. In contrast, the fecal CORT level in the GABA group was significantly reduced to 23.98 pg/mg and was comparable to that in the control group (33.38 pg/mg). Reduced serum CORT level in the GABA group suggests an improvement in depressive symptomatology. The serotonin concentration was maintained in the GABA group after the induction of depression, suggesting its preventive activity. The HPP GABA-enriched soybeans exerted modulatory effects on the behaviors of depressed mice and displayed a potential for commercialization.

show abstract

Gamma-Aminobutyric Acid Binds to GABAB Receptor to Inhibit Cholangiocarcinoma Cells Growth via the JAK/STAT3 Pathway

Abstract: GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK/STAT3 pathway.

Cited by 16 publications

References 29 publications

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

γ-Aminobutyric acid found in fermented foods and beverages: current trends

Increasing γ-Aminobutyric Acid Content in Vegetable Soybeans via High-Pressure Processing and Efficacy of Their Antidepressant-Like Activity in Mice

Contact Info

Product

Resources

About

Gamma-Aminobutyric Acid Binds to GABAB Receptor to Inhibit Cholangiocarcinoma Cells Growth via the JAK/STAT3 Pathway

Abstract: GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK/STAT3 pathway.

Cited by 16 publications

References 29 publications

GABABR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

GABABR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

γ-Aminobutyric acid found in fermented foods and beverages: current trends

Increasing γ-Aminobutyric Acid Content in Vegetable Soybeans via High-Pressure Processing and Efficacy of Their Antidepressant-Like Activity in Mice

Contact Info

Product

Resources

About

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells

GABA_BR/GSK‐3β/NF‐κB signaling pathway regulates the proliferation of colorectal cancer cells