Gamma-Band Modulation and Coherence in the EEG by Involuntary Eye Movements in Patients in Unresponsive Wakefulness Syndrome

Abstract

Gamma power and coherence in the electroencephalogram increase in healthy individuals in association with voluntary eye movements, saccades. Patients with unresponsive wakefulness syndrome show repetitive involuntary eye movements that are similar to saccades but progress at a much lower speed. In the present study, we explored the changes in gamma power and coherence related to these eye movements and investigated whether any relationship to the patients' clinical status could be found that would indicate first neurophysiological signs of recovery. To this end, we assessed the clinical status and registered classical scalp electroencephalography with 19 surface electrodes and electro-oculogram of 45 consecutive patients at admission and at 4 weekly intervals. Slow gamma activity (in the frequency range of 37-40 Hz) was analyzed before, during, and after eye movements (pre, -intra and post-eye movement) by means of "continuous wavelet transform." We graded recovery using clinical behavioral scales, taking into account the variables, age, gender, recovery (yes or no), as well as the patients diagnoses (traumatic brain injury, hypoxia, hemorrhage, infection). Statistical evaluation was performed using DataLab, R, and Kruskal-Wallis methods. Based on the clinical status, we distinguished between recovering and chronic groups of patients. In comparison with the chronic group, the recovering group showed significantly higher gamma power over the posterior electrodes and significant higher values of coherence in the gamma-band activity during the presaccadic period of eye movements. We suggest that our findings on the onset of involuntary eye movements in the recovering group of patients with unresponsive wakefulness syndrome indicates a first neurophysiological sign of favorable prognosis.

Large Scale Functional Brain Networks Underlying Temporal Integration of Audio-Visual Speech Perception: An EEG Study

“…Gamma band coherence are shown to be associated with voluntary eye movements, saccades (Balazs et al, 2015 ). Besides, stimulus selection by attention also induces local gamma band synchronization (Hipp et al, 2011 ).…”

“…A traditional measure of large-scale functional connectivity in EEG is the sensor-level global coherence (Cimenser et al, 2011 ; Balazs et al, 2015 ; Fonseca et al, 2015 ; Alba et al, 2016 ; Clarke et al, 2016 ). Global coherence can be described as either the normalized vector sum of all pairwise coherences between sensor combinations, the frequency domain representation of cross-correlation between two time-series (Lachaux et al, 1999 ; Cimenser et al, 2011 ) or the ratio of the largest eigenvalue of the cross-spectral matrix to the sum of its eigenvalues (Mitra and Bokil, 2008 ).…”

Predicting Response to McGurk Illusion Based on Periodic and Aperiodic Prestimulus EEG Activity

“…Nonetheless, the parametrized power does not tell us much about the sensor level’s whole-brain functional connectivity (FC) dynamics. To compute the large-scale functional connectivity, one can perform global coherence (Cimenser et al, 2011; Balazs et al, 2016; Fonseca et al, 2015; Kumar et al, 2016). Global coherence is a mathematical technique used to capture and quantify the strength of the covariation of neural oscillations at the global (or whole-brain) scale (Railo, Koivisto, & Revonsuo, 2011).…”